Louise McGuane launched Irish-whiskey label JJ Corry in 2015 after spending more than 20 years working in marketing for premium drinks brands. She has revived the practice of whiskey bonding, a popular practice in Ireland before the industry was decimated in the 1930s. McGuane sources, matures and bottles her own blends and single malts from her family farm in County Clare.
From a MedPageToday online article:
“Amyloid is important in initiating disease, but the actual damage in the brain is probably due to the accumulation of tau,” Holtzman told MedPage Today. “Normally, tau protein is inside cells, but there is more and more evidence suggesting that its spread to different parts of the brain is responsible for the progression of Alzheimer’s disease.”
Two studies in January explored how sleep might be associated with Alzheimer’s tau pathology. The first, led by Brendan Lucey, MD, and David Holtzman, MD, both of Washington University in St. Louis, found that older adults who had less slow-wave sleep had higher levels of brain tau.
The findings, published in Science Translational Medicine, suggested that poor quality sleep in late life may signal deteriorating brain health.
Sleep patterns predicted amyloid and tau burden, reported Matthew Walker, PhD, of the University of California Berkeley, and co-authors, in June.
Marrakech can be full of dirty details but exploring Morocco is just fine at 90km/h. Take out some cash and jump in.Available now at The Monocle Shop: https://monocle.com/shop/product/1603…
The Fiat 8V (or “Otto Vu”) is a V8-engined sports car produced by the Italian car manufacturer Fiat from 1952 to 1954. The car was introduced at the 1952 Geneva Motor Show. The Fiat 8V got its name because at the time of its making, Fiat believed Ford had a copyright on “V8”. With 114 made, the 8V wasn’t a commercial success, but did well in racing. Apart from the differential the car did not share any parts with the other Fiats (but many parts were made by Siata and they used them for their cars). The 8V was developed by Dante Giacosa and the stylist Luigi Rapi. The engine was a V8 originally designed for a luxury sedan, but that project was stopped.
Ghia designed and produced a limited run of cars named ‘Supersonic’, with special ‘jet age’ bodywork. Ghia had recently been sold by Boano to Luigi Segre, and a one-off Alfa Romeo 1900 had been built for a wealthy entrant in the 1953 Mille Miglia race. The car was displayed at the Turin show same year and the reaction inspired Segre to plan a limited production of cars based on the Otto Vu, aimed at the American market. Only eight were completed, after mechanical issues ended the project. Several of the cars were purchased by Americans; some were heavily customized and received engine transplants. An original un-restored car sold at a Scottsdale, Arizona Gooding and Company auction in January 2011 with a gavel price of US$1.55 million ($1.7M including buyer’s premium). Ghia would later use its basic body shape on Jaguar XK-120–based vehicles as well as Aston Martin. Design of ‘Supersonic’ is credited to Giovanni Savonuzzi.
From Wikipedia
Listen to the latest from the world of science, brought to you by Benjamin Thompson and Nick Howe. This week, observations of objects orbiting a black hole, and rethinking how we measure screen-time.In this episode:
Researchers have uncovered a population of dust-enshrouded objects orbiting the supermassive black hole at the centre of the galaxy. Research Article: Ciurlo et al.
A London landmark’s height lends itself to a physics experiment, and generous behaviour in parrots. Research Highlight: An iconic structure in London moonlights as a scientific tool; Research Highlight: Parrots give each other gifts without promise of reward
To understand the effects of online media consumption, researchers argue that the way it’s measured needs to change. Comment: Time for the Human Screenome Project
A decline in human body temperature, and a new report on research culture. News: Not so hot: US data suggests human bodies are cooling down; News: Stressful, aggressive, damaging: huge survey reveals pressures of scientists’ working lives
Pianist Ronald Brautigam explains Beethoven unique and revolutionary ability to appeal to both the masses and the connoisseurs of his time.
Pianist Lada Valešová and historian Cliff Eisen discuss Mozart earliest composition, written when he was just five years old.
From a Cedars-Sinai.org online release:
“Our data showed that rates of accelerating blood pressure elevation were significantly higher in women than men, starting earlier in life,” said Cheng, the Erika J. Glazer Chair in Women’s Cardiovascular Health, who also serves as director of Cardiovascular Population Sciences at the Barbra Streisand Women’s Heart Center. “This means that if we define the hypertension threshold the exact same way, a 30-year old woman with high blood pressure is probably at higher risk for cardiovascular disease than a man with high blood pressure at the same age.”
(January 15, 2020) – New research from the Smidt Heart Institute at Cedars-Sinai showed for the first time that women’s blood vessels – including both large and small arteries – age at a faster rate than men’s. The findings, published Wednesday in the journal JAMA Cardiology, could help to explain why women tend to develop different types of cardiovascular disease and with different timing than men.
With more and more people taking flight each year, there’s a lot that can go wrong. WSJ’s Scott McCartney tallies the data for a definitive look at which airlines performed best and worst in 2019 in key categories like on-time departures, baggage handling and flight cancellations.
More from the Wall Street Journal: Visit WSJ.com: http://www.wsj.com
January 13, 2020 – The prestigious Ocean Art Underwater Photo Competition, organized by the Underwater Photography Guide, has announced its 2019 winners. The 8th annual competition attracted an extremely high caliber of photos from oceans around the world. These photos showcase the best underwater photographs of the year. 2019 was one of the most competitive years to date. Our two new categories, conservation and blackwater diving, had an overwhelming response of incredible photos and were two of the highlights of the competition.
Filmed and Directed by: Arvīds Barānovs
In 2019 I led two expeditions into the wild Iceland. We skipped the most touristy spots you have probably seen a million times on Instagram and went deep into the Highlands and around the remote Westfjords including a long multi-day hike in Hornstrandir to find the real taste of this beautiful land.
In summer 2020 I will be returning with another Westfjords expedition and you’re welcome to join our small group: facebook.com/events/427469747931313/
Boomers Daily 