Depression is associated with increased odds of dementia, even more than 20 years after diagnosis of depression, and the association remains after adjustment for familial factors. Further research is needed to investigate whether successful prevention and treatment of depression decrease the risk of dementia.
The risk of dementia is increased for decades after a diagnosis of depression, where those diagnosed with especially severe depressions are at increased risk.
Dementia is common among the elderly, causing severe individual suffering as well as societal strain. As the proportion of people aged 65 years and above is rapidly increasing in the world population, the number of individuals with dementia is expected to double within 20 years, and this condition was estimated to have a worldwide cost of US$604 billion in 2010. Effective treatments for dementia remain scarce; however, a preventive approach may be possible through the identification of high-risk individuals and potentially modifiable risk factors.
Scientists have just discovered a new mechanism that can be key in regulating these immune attacks, raising new hopes of drugs that can protect against joint inflammation and the ailments it can bring.
Through the use of the CRISPR gene-editing tool, the Karolinska Institutet scientists have now shed further light on the role they play in inflammation. The technology enabled the team to make adjustments to a set of hand-picked immune cell genes as a way of learning how those tweaks can impact the behavior of the cells.
“The results we obtained using CRISPR were key to quickly understanding how the system under study is regulated,” says Dr Wermeling. “I have high hopes that the experimental use of CRISPR will be hugely important to our understanding of how immune-cell behavior is regulated, and that this can guide us in the development of new efficacious drugs.”
From a Journal of the American College of Cardiology:
Observational data suggest associations between marijuana and a broad range of adverse cardiovascular risks. Marijuana is becoming increasingly potent, and smoking marijuana carries many of the same cardiovascular health hazards as smoking tobacco. Synthetic cannabinoids have been linked to more sustained and deleterious pharmacodynamic effects.
Marijuana use is increasing as more states are legalizing cannabis for both medicinal and recreational purposes. National survey data estimate that >2 million Americans with established cardiovascular diseases currently use or have used marijuana in its variety of forms, including inhalation and vaping. Cannabinoid receptors are distributed in multiple tissue beds and cells, including platelets, adipose tissue, and myocytes.
• We estimate that >2 million U.S. adults who have reported ever using marijuana have cardiovascular disease.
• Observational studies have suggested an association between marijuana use and a range of cardiovascular risks.
• Marijuana is becoming increasingly potent, and smoking marijuana carries many of the same cardiovascular health hazards as smoking tobacco.
• Few randomized clinical trials have been conducted or are planned to explore the effects of marijuana on cardiovascular risk.
• Screening and testing for use of marijuana are encouraged in clinical settings, especially in the care of young patients presenting with cardiovascular disease.
Researchers in Germany published a study in the journal Pain in December showing that open-label placebos can help relieve chronic lower-back pain, replicating a 2016 study. A similar study by University of Colorado, Boulder researchers found that placebo saline injections reduce chronic lower-back pain.
Two other recent studies showed placebos openly given to cancer patients helped relieve cancer-related fatigue. And a forthcoming study by German researchers found openly giving placebo to elderly patients helped improve knee pain.
More researchers are looking at the idea of placebos—substances that have no actual pharmaceutical effect—as an alternative to traditional pain medications, which can be ineffective and carry significant side effects. Placebos might have particular potential for difficult-to-treat conditions like chronic back pain, cancer-related fatigue and symptoms of irritable bowel syndrome, researchers hope.
As many as 30% to 50% of chronic pain patients will respond to placebos, research suggests. And new studies are helping to identify genetic and brain differences that make certain people more likely to respond.
From a Genetic Engineering & Biotechnology News online article:
“We were able to show that if you can stop the plasmid from replicating, then most of the bacteria lose the plasmid as the bacteria grow and divide. This means that infections that might otherwise be hard to control, even with the most powerful antibiotics available, are more likely to be treatable with standard antibiotics.”
Researchers headed by a team at the University of Birmingham in the U.K. have developed a probiotic drink containing genetic elements that are designed to thwart antimicrobial resistance (AMR) in gut bacteria at the genetic level. The drink targets small DNA elements called plasmids that carry antibiotic resistance genes, and which are able to replicate independently and spread between bacteria. By preventing these plasmids from replicating, the antibiotic resistance genes are displaced, effectively resensitizing the bacteria to antibiotics.
“Our data showed that rates of accelerating blood pressure elevation were significantly higher in women than men, starting earlier in life,” said Cheng, the Erika J. Glazer Chair in Women’s Cardiovascular Health, who also serves as director of Cardiovascular Population Sciences at the Barbra Streisand Women’s Heart Center. “This means that if we define the hypertension threshold the exact same way, a 30-year old woman with high blood pressure is probably at higher risk for cardiovascular disease than a man with high blood pressure at the same age.”
(January 15, 2020) – New research from the Smidt Heart Institute at Cedars-Sinai showed for the first time that women’s blood vessels – including both large and small arteries – age at a faster rate than men’s. The findings, published Wednesday in the journal JAMA Cardiology, could help to explain why women tend to develop different types of cardiovascular disease and with different timing than men.
From a JAMA Otolaryngol Head Neck Surgery article:
Cell phone–related injuries to the head and neck have increased steeply over the recent 20-year period, with many cases resulting from distraction. Although the disposition of most cases is simple, some injuries bear a risk of long-term complications. Many of these injuries occurred among those aged 13 to 29 years and were associated with common activities, such as texting while walking. These findings suggest a need for patient education about injury prevention and the dangers of activity while using these devices.
Since their invention, cell phones have played a major role in the daily lives of American adults. Approximately 96% of Americans own a cell phone, provoking interest in their role in causing injury. Given that head and neck traumas make up approximately 5% of emergency department (ED) visits in the United States, cell phone use in relation to such injuries could be of public health concern, in particular because of the psychological and financial burdens such injuries may entail. In addition, knowledge of the mechanism of injury is vital for patient risk stratification and trauma management,and understanding the mechanisms of common cell phone–related injuries can aid health care professionals in assessing patient needs. Health care professionals and public safety officials also must be aware of the epidemiologic nature of such injuries in order to provide adequate counseling and give input for legislation to protect the population.