Category Archives: Studies

Health Studies: Sleep Problems Prevent Long-Term Recovery From Chronic Low Back Pain

From a MedScape online release:

Chronic Lower Back PainSleep problems may decrease the likelihood of recovery from chronic low back pain (LBP) over the long term and those who have musculoskeletal pain on top of insomnia have an even lower possibility of recovery, a study has found.

“The probability of recovery [from LBP] is especially low among persons who often/always experience sleeplessness and who also suffer from co-occurring musculoskeletal pain,” the researchers write.

The study took place over more than 10 years and also found the likelihood of recovery from chronic LBP decreased further among people with muscle and joint pains, in addition to sleeplessness.

The researchers conducted a prospective cohort study that included 3712 women and 2488 men aged at least 20 years who participated in the HUNT study, one of the largest, longest running health studies in Norway. HUNT began in 1984 and has data on over 120,000 participants.

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Health Studies: Aspirin Use 3+ Times Per Week Reduces “All-Cause” Cancers In Older Adults (JAMA)

From a JAMA Open Network online release:

JAMAThis cohort study included 146 152 individuals from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial and found that aspirin use 3 or more times per week was associated with reduced risk of all-cause, cancer, gastrointestinal cancer, and colorectal cancer mortality.

Importance  Aspirin use has been associated with reduced risk of cancer mortality, particularly of the colorectum. However, aspirin efficacy may be influenced by biological characteristics, such as obesity and age. With the increasing prevalence of obesity and conflicting data regarding the effect of aspirin in older adults, understanding the potential association of aspirin use with cancer mortality according to body mass index (BMI) and age is imperative.

Objectives  To investigate the association of aspirin use with risk of all-cause, any cancer, gastrointestinal (GI) cancer, and colorectal cancer (CRC) mortality among older adults and to perform an exploratory analysis of the association of aspirin use with mortality stratified by BMI.

Design, Setting, Participants  This cohort study evaluated aspirin use among participants aged 65 years and older in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial at baseline (November 8, 1993, to July 2, 2001) and follow-up (2006-2008). Analysis began in late 2018 and was completed in September 2019.

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Healthcare Studies: High Level Of Depression Symptoms In Physicians Linked To Medical Errors

From a JAMA Network online release:

JAMAThis systematic review and meta-analysis of 11 studies involving 21 517 physicians demonstrated an association between physician depressive symptoms and an increased risk for perceived medical errors (RR, 1.95; 95% CI, 1.63-2.33). We also found that the magnitude of the associations of physician depressive symptoms and perceived medical errors were relatively consistent across studies that assessed training and practicing physicians, providing additional evidence that physician depression has implications for the quality of care delivered by physicians at different career stages.

Medical errors are a major source of patient harm. Studies estimate that, in the United States, as many as 98 000 to 251 000 hospitalized patients die each year as result of a preventable adverse event.14 In addition, medical errors are a major source of morbidity5 and account for billions of dollars in financial losses to health care systems every year.69

Depressive symptoms are highly prevalent among physicians,10,11 and several studies have investigated the associations between physician depressive symptoms and medical errors.1216 Although most studies on physician depressive symptoms and medical errors have identified a substantial association, their results are not unanimous, and questions regarding the direction of these associations remain open in recent literature.17

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Health Study: Death From Heart Disease Four Times Higher In Women With “Poor Exercise Capacity”

From a European Society of Cardiology online release:

European Society of Cardiology ESCThe annual rate of death from cardiovascular disease was nearly four times higher in women with poor, compared to good, exercise capacity (2.2% versus 0.6%). Annual cancer deaths were doubled in patients with poor, compared to good, exercise capacity (0.9% versus 0.4%). The annual rate of death from other causes was more than four times higher in those with poor, compared to good, exercise capacity (1.4% vs. 0.3%).

Women who can exercise vigorously are at significantly lower risk of dying from heart disease, cancer and other causes. The research is presented today at EuroEcho 2019, a scientific congress of the European Society of Cardiology (ESC).1

During a median follow-up of 4.6 years there were 345 cardiovascular deaths, 164 cancer deaths, and 203 deaths from other causes. After adjusting for factors that could influence the relationship, METs were significantly associated with lower risk of death from cardiovascular disease, cancer, and other causes.

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Diet Studies: “10-Hour Time -Restricted Eating” (TRE) Lowers Weight, Visceral Fat & Blood Pressure

From a Cell Metabolism online study release:

Cell Metabolism December 2019Ten-hour time-restricted eating (TRE) limits daily dietary intake to a consistent 10-h window, creating a 14-h nightly fast. Researchers studied whether TRE for 12 weeks in people with metabolic syndrome receiving standard medical care (including medications to lower cholesterol and blood pressure) improves markers of health. TRE led to weight loss, healthier body composition (including decreased waist circumference), lower blood pressure and levels of cardiovascular disease-promoting lipids (i.e., “bad cholesterol” levels), and more restful sleep. TRE could be an effective dietary intervention to help those with metabolic syndrome.

10 Hour Time Restricted Eating (TRE) Benefits

Time-restricted eating (TRE) is an emerging dietary intervention that aims to maintain a consistent daily cycle of feeding and fasting to support robust circadian rhythms (Panda, 2016). Circadian regulation of the endocrine system, autonomic nervous system, and nutrient metabolism contributes to metabolic and physiological homeostasis (Asher and Sassone-Corsi, 2015,Panda, 2016). Both erratic eating patterns and eating over an extended period of time during the 24-h day can disrupt circadian rhythms.

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Health Studies: Lifelong Exercise Promotes “Anti-Inflammation” In Skeletal Muscle (

From a Journal of Applied Physiology online abstract:

Journal of Applied PhysiologyThus, while aging led to a pro-inflammatory profile within blood and muscle, lifelong exercise partially prevented this and generally preserved the acute inflammatory response to exercise seen in young exercising men. Lifelong exercise may positively impact muscle health throughout aging by promoting anti-inflammation in skeletal muscle.

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From a New York Times article review of study:

Taken as a whole, these results suggest that long-term exercise may help aging muscles remain healthy in part by readying them to dissipate inflammation, Dr. Trappe says. But on the flip side, sedentary living seems to set up muscles to overreact to strain and remain inflamed, potentially leading to fewer muscular gains when someone does exercise.

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Studies: “Blood-Based ‘Liquid Health Check’ Beats Traditional Predictors of Multiple Disease Risks” (Nature)

From a Genetic Engineering & Biotechnology News release:

Nature Medicine Journal Dec 2019“This proof of concept study demonstrates a new paradigm that measurement of blood proteins can accurately deliver health information that spans across numerous medical specialties and that should be actionable for patients and their healthcare providers,” said Peter Ganz, MD, co-leader of this study and the Maurice Eliaser distinguished professor of medicine at UCSF and director of the Center of Excellence in Vascular Research at Zuckerberg San Francisco General Hospital and Trauma Center. 

Specific patterns of protein levels in our blood could be used to provide a comprehensive “liquid health check” that gives a snapshot of health and potentially an indication of the likelihood that we will develop certain diseases or health risk factors in the future, according to research by scientists in the U.S. and U.K. working with SomaLogic. The results of their proof-of-concept study involving more than 16,000 participants, and published in Nature Medicine, showed that while the accuracy of models based on specific protein expression patterns varied, they were all either better predictors than models based on traditional risk factors, or would constitute more convenient and less expensive alternatives to traditional testing.

Study published in Nature Medicine:

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