Video Profiles: London Architect Richard Found In His Cotswold Retreat

When designer Richard Found discovered the dream plot on which to build his serene contemporary retreat overlooking a lake, he didn’t bet on what happened next. In the grounds stood a derelict 18th-century gamekeeper’s cottage, which was immediately spot-listed by Historic England. “It changed the whole dynamic of what I thought would be a straightforward new-build project, and became a far more arduous planning exercise.”…

House Proud is a series of videos created by the Telegraph which showcase some of Britain’s most idiosyncratic, quirky, unusual and unforgettable homes. A celebration of British eccentricity and imagination, in each film the owner gives us an intimate guided tour and tells us the story of their unique property.

Richard Found's Radical Retreat Gloucestershire England The Telegraphy Video January 16 2020

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Fine Art: The History Behind “The Dream” By Henri Rousseau (1910)

Artist Henri Rousseau painted The Dream in 1910, and it’s imagery of a woman lounging on a sofa in the middle of a jungle was as surreal then as it is today. What is it about this artwork that captivated audiences then and now?

The Sleeping Gypsy 1897 Henri Rousseau
The Sleeping Gypsy 1897 Henri Rousseau

Thanks to our Grandmasters of the Arts Tyler Calvert-Thompson, Divide by Zero Collection, David Golden, and Ernest Wolfe, and all of our patrons, especially Rich Clarey, Iain Eudaily, Frame Monster Design Laboratory, Patrick Hanna, Nichole Hicks, Andrew Huynh, Eve Leonard, David Moore, Gabriel Civita Ramirez, Constance Urist, Nicholas Xu, and Roberta Zaphiriou.

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Pop Art Books: “Mirages – The Art Of Laurent Durieux” (March 2020)

Mirages The Art of Laurent DurieuxLaurent Durieux is a famous Belgian illustrator well known to lovers of pop culture and collectors for his reinterpretations of posters of cult films. Each of his American exhibitions was sold out during the opening night and in the presence of thousands of enthusiastic fans.

This book will be his first monograph and will cover his entire career, with a particular focus on his posters of the most emblematic alternative films (notably Jaws, The Birds, Vertigo and The Master). The book includes a 6-page section of art on rejected and unpublished posters and a preface by filmmaker and collector Durieux Francis Ford Coppola.

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Top New Science Podcasts: Lack Of Clinical Trial Reporting, Gut Microbe Links To Chronic Disease

Science Magazine PodcastsThough a law requiring clinical trial results reporting has been on the books for decades, many researchers have been slow to comply. Now, 2 years after the law was sharpened with higher penalties for noncompliance, investigative correspondent Charles Piller took a look at the results. He talks with host Sarah Crespi about the investigation and a surprising lack of compliance and enforcement.

Also this week, Sarah talks with Brett Finlay, a microbiologist at the University Of British Columbia, Vancouver, about an Insight in this week’s issue that aims to connect the dots between noncommunicable diseases like heart disease, diabetes, and cancer and the microbes that live in our guts. Could these diseases actually spread through our microbiomes?

Study: “Probiotic Drink” Developed That Thwarts Antibiotic Resistance

From a Genetic Engineering & Biotechnology News online article:

Genetic Engineering & Biotechnology News logo“We were able to show that if you can stop the plasmid from replicating, then most of the bacteria lose the plasmid as the bacteria grow and divide. This means that infections that might otherwise be hard to control, even with the most powerful antibiotics available, are more likely to be treatable with standard antibiotics.”

journal.pone.0225202.g001
Fig 1. Anticipated exploitation of pCURE as a probiotic treatment for at-risk individuals. Before treatment, plasmids carrying antibiotic resistance genes are shown as purple circles. After treatment, target plasmids are replaced by pCURE (green circle) which could be engineered to later “self-destruct”. Note that not all gut bacteria carry resistance plasmids but pCURE can enter all Enterobacteriaceae as well as other bacteria. Reduced resistance levels in the gut decrease the chance of treatment failure when infections elsewhere in the body (eg lungs or urinary tract) arise from gut bacteria.

 

Researchers headed by a team at the University of Birmingham in the U.K. have developed a probiotic drink containing genetic elements that are designed to thwart antimicrobial resistance (AMR) in gut bacteria at the genetic level. The drink targets small DNA elements called plasmids that carry antibiotic resistance genes, and which are able to replicate independently and spread between bacteria. By preventing these plasmids from replicating, the antibiotic resistance genes are displaced, effectively resensitizing the bacteria to antibiotics.

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Podcast Interview: JJ Corry Irish Whiskey Founder Louise McGuane On Whiskey Bonding

Monocle 24 The EntrepreneursLouise McGuane launched Irish-whiskey label JJ Corry in 2015 after spending more than 20 years working in marketing for premium drinks brands. She has revived the practice of whiskey bonding, a popular practice in Ireland before the industry was decimated in the 1930s. McGuane sources, matures and bottles her own blends and single malts from her family farm in County Clare.

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The Flintlock 16 Year Old Single Malt Limited Edition

J.J. Corry Irish Whiskey Label

Studies: Alzheimer’s Disease Linked To Poor Sleep In Older Adults

From a MedPageToday online article:

Science Translational Medicine“Amyloid is important in initiating disease, but the actual damage in the brain is probably due to the accumulation of tau,” Holtzman told MedPage Today. “Normally, tau protein is inside cells, but there is more and more evidence suggesting that its spread to different parts of the brain is responsible for the progression of Alzheimer’s disease.”

Two studies in January explored how sleep might be associated with Alzheimer’s tau pathology. The first, led by Brendan Lucey, MD, and David Holtzman, MD, both of Washington University in St. Louis, found that older adults who had less slow-wave sleep had higher levels of brain tau.

The findings, published in Science Translational Medicine, suggested that poor quality sleep in late life may signal deteriorating brain health.

Sleep patterns predicted amyloid and tau burden, reported Matthew Walker, PhD, of the University of California Berkeley, and co-authors, in June.

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Rare Classic Cars: “1953 Fiat 8V Supersonic” By Ghia

1953 Fiat 8V Supersonic by Ghia Interior RM Sotheby'sThe Fiat 8V (or “Otto Vu”) is a V8-engined sports car produced by the Italian car manufacturer Fiat from 1952 to 1954. The car was introduced at the 1952 Geneva Motor Show. The Fiat 8V got its name because at the time of its making, Fiat believed Ford had a copyright on “V8”. With 114 made, the 8V wasn’t a commercial success, but did well in racing. Apart from the differential the car did not share any parts with the other Fiats (but many parts were made by Siata and they used them for their cars). The 8V was developed by Dante Giacosa and the stylist Luigi Rapi. The engine was a V8 originally designed for a luxury sedan, but that project was stopped.

Ghia Supersonic

Ghia designed and produced a limited run of cars named ‘Supersonic’, with special ‘jet age’ bodywork. Ghia had recently been sold by Boano to Luigi Segre, and a one-off Alfa Romeo 1900 had been built for a wealthy entrant in the 1953 Mille Miglia race. The car was displayed at the Turin show same year and the reaction inspired Segre to plan a limited production of cars based on the Otto Vu, aimed at the American market. Only eight were completed, after mechanical issues ended the project. Several of the cars were purchased by Americans; some were heavily customized and received engine transplants. An original un-restored car sold at a Scottsdale, Arizona Gooding and Company auction in January 2011 with a gavel price of US$1.55 million ($1.7M including buyer’s premium). Ghia would later use its basic body shape on Jaguar XK-120–based vehicles as well as Aston Martin. Design of ‘Supersonic’ is credited to Giovanni Savonuzzi.

From Wikipedia