From a Science Magazine online article:
They found that these physically active mice had fewer inflammatory cells (leukocytes) than sedentary mice, an effect they traced to diminished activity of hematopoietic stem and progenitor cells (HSPCs). The lower activity of HSPCs was due at least in part to exercise-induced reduction in the levels of leptin, a hormone produced by fat tissue that regulates cells within the hematopoietic bone marrow niche.
Regular physical activity is associated with a lower rate of death from heart disease, but the underlying mechanisms are not fully understood. Frodermann et al. examined the effect of exercise on cardiovascular inflammation, a known risk factor for atherosclerosis, by studying mice that voluntarily ran for long distances on exercise wheels.
To read more: https://science.sciencemag.org/content/366/6469/1091.2
From a Stanford Medicine online release:
“For patients with severe but stable heart disease who don’t want to undergo these invasive procedures, these results are very reassuring,” said David Maron, MD, clinical professor of medicine and director of preventive cardiology at the Stanford School of Medicine, and co-chair of the trial, called ISCHEMIA, for International Study of Comparative Health Effectiveness with Medical and Invasive Approaches.
“The results don’t suggest they should undergo procedures in order to prevent cardiac events,” added Maron, who is also chief of the Stanford Prevention Research Center.
Patients with severe but stable heart disease who are treated with medications and lifestyle advice alone are no more at risk of a heart attack or death than those who undergo invasive surgical procedures, according to a large, federally-funded clinical trial led by researchers at the Stanford School of Medicine and New York University’s medical school.
The trial did show, however, that among patients with coronary artery disease who also had symptoms of angina — chest pain caused by restricted blood flow to the heart — treatment with invasive procedures, such as stents or bypass surgery, was more effective at relieving symptoms and improving quality of life.
To read more: http://med.stanford.edu/news/all-news/2019/11/invasive-heart-treatments-not-always-needed.html
From a Wall Street Journal online article:
The rapid aging of the population, together with high rates of obesity and diabetes in all ages, are pushing both the rate and number of deaths from heart failure higher, the study said. Most deaths from heart failure occur in older Americans, but they are rising in adults under 65, too, the study showed.
The findings help explain why a decadeslong decline in the death rate from cardiovascular disease has slowed substantially since 2011 and started rising in middle-aged people, helping drive down U.S. life expectancy.
Deaths from heart failure, one of the nation’s biggest killers, are surging as the population ages and the health of younger generations worsens.
The death rate from the chronic, debilitating condition rose 20.7% between 2011 and 2017 and is likely to keep climbing sharply, according to a study published Wednesday in the journal JAMA Cardiology.
To read more: https://www.wsj.com/articles/heart-failure-deaths-rise-contributing-to-worsening-life-expectancy-11572411901
From a Science Daily online release:
“People with heart failure cannot do everything that a healthy individual can, so the question becomes how much exercise can they handle and what type of impact will it have on their health,” Emter said. “We found that regardless of intensity level, some type of physical activity was good for heart health compared to no exercise at all.”
Now, research from the University of Missouri has found exercise can improve the health of blood vessels in the heart for people with heart failure. The finding is based on a study looking at swine, which have very similar blood vessels and heart muscles — both structurally and functionally — as humans.
To read more: https://www.sciencedaily.com/releases/2019/10/191022174402.htm
From a ScienceDaily.com online release:
Physical inactivity, smoking, high blood pressure, diabetes, and high cholesterol play a greater role than genetics in many young patients with heart disease, according to research presented today at ESC Congress 2019 together with the World Congress of Cardiology. The findings show that healthy behaviours should be a top priority for reducing heart disease even in those with a family history of early onset.
The study enrolled 1,075 patients under 50, of whom 555 had coronary artery disease (known as premature CAD). Specific conditions included stable angina, heart attack, and unstable angina. The average age was 45 and 87% were men. Risk factor levels and genetics in patients were compared to a control group of 520 healthy volunteers (average age 44, and 86% men). Patients and controls were recruited from the Genes in Madeira and Coronary Disease (GENEMACOR) database.
Five modifiable risk factors were assessed: physical inactivity, smoking, high blood pressure, diabetes, and high cholesterol. Nearly three-quarters (73%) of patients had at least three of these risk factors compared to 31% of controls. In both groups, the likelihood of developing CAD increased exponentially with each additional risk factor. The probability of CAD was 3, 7, and 24 times higher with 1, 2, and 3 or more risk factors, respectively.
To read more: https://www.sciencedaily.com/releases/2019/09/190902181602.htm
From a New York Times article by Lisa Sanders, M.D.:
In sarcoidosis, abnormal collections of cells called granulomas invade the organ, interfering with its normal activity and often destroying the surrounding tissue. What is left is a scar, known as fibrosis, dotted with these abnormal granulomas.
When caught early, sarcoidosis can be treated and the destruction slowed or even stopped. But it was too late for that in this man’s case. He was started on immune-suppressing medications to prevent additional damage, but he needed a new heart.
The man had been active and healthy, until five years earlier when he started to feel tired. His doctor sent him to a cardiologist, who took one look at his EKG and said he needed a pacemaker, right away. He got one the next day. He was fine for a year, and then, on a business trip to Atlanta, he suddenly felt lightheaded, and his heart fluttered wildly in his chest. In the E.R. they told him his heart was beating 220 beats a minute. You should be dead, one doctor said.
To read more click on the following link: https://www.nytimes.com/2019/08/22/magazine/why-was-the-middle-aged-mans-heart-beating-so-dangerously-fast.html
From The Lancet issue August 24, 2019:
Use of polypill was effective in preventing major cardiovascular events. Medication adherence was high and adverse event numbers were low. The polypill strategy could be considered as an additional effective component in controlling cardiovascular diseases, especially in LMICs.
When restricted to participants in the polypill group with high adherence, the reduction in the risk of major cardiovascular events was even greater compared with the minimal care group…
A fixed-dose combination therapy (polypill strategy) has been proposed as an approach to reduce the burden of cardiovascular disease, especially in low-income and middle-income countries (LMICs). The PolyIran study aimed to assess the effectiveness and safety of a four-component polypill including aspirin, atorvastatin, hydrochlorothiazide, and either enalapril or valsartan for primary and secondary prevention of cardiovascular disease.
To read more click on the following link: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)31791-X/fulltext