Category Archives: Aging

Epigenetics & Aging: DNA Breakage & Repair Effects

Harvard Medical School – A 13-year international study in mice demonstrates that loss of epigenetic information, which influences how DNA is organized and regulated, can drive aging independently of changes to the genetic code itself.

It also shows that restoring the integrity of the epigenome reverses age-related symptoms.

Learn more at https://hms.harvard.edu/news/loss-epi…

Photography: National Geographic – January 2023

Picture of an older man skydiving surrounded by a yellow border and the words "Living longer–and better. How science could change the way we age."
At 69, skydiving instructor Arnold Camfferman stays active, one of the keys to longevity. As the world grows older, research into the field is soaring.

National Geographic Magazine – January 2023 issue:

• ​Can aging be cured? Scientists are giving it a try.
• A detailed look at how we age—at the cellular level
• We rallied to save manatees once. Can we do it again?
• How manatees eat 100 pounds of food a day
• This ancient Himalayan kingdom has been isolated from the world—until now
• Inside a 15th-century kingdom’s treasure-filled temple
• Bolivian skateboarders use Indigenous attire to battle discrimination

Aging: Healthy Longevity Journal – December 2022

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December 2022 issue:

Long COVID and older people

Long COVID is a poorly understood condition, with a wide spectrum of effects on multiple body systems and variable presentation in different individuals. Long COVID is of particular concern among older people (ie, aged 65 years or older), who are at greater risk than younger people of persisting symptoms associated with COVID-19. In addition, COVID-19 might trigger or exacerbate chronic conditions that occur commonly in older people, such as cardiovascular diseases, respiratory diseases, neurodegenerative conditions, and functional decline.

Quantum Healthy Longevity for healthy people, planet, and growth

It is widely thought that lifespans are increasing globally. However, life expectancy has begun to stagnate in the UK, and is falling in more than 50 countries including the USA. Lifespan stagnation or decrease is a consequence of socioeconomic inequalities, lifestyle factors, and the COVID-19 pandemic. In the UK, the National Health Service spends vast sums treating chronic diseases; by some estimates, 40% of its costs go to treating preventable conditions.

Is age-related hearing loss a potentially modifiable risk factor for dementia?

The relationship of measures of age-related hearing loss such as pure-tone autiometry might not be as consistently associated with risk of dementia as previous studies have suggested. Peripheral age-related hearing loss has been posited as a midlife risk factor for dementia.

REVIEWS: THE TOP 5 ARTICLES ON HEALTHY AGING IN 2022

National Institute on Aging – As 2022 comes to a close, NIA invites you to explore some of the most popular health information topics from this past year:

High Blood Pressure and Older Adults

— High blood pressure, or hypertension, is common in older adults. The good news is that blood pressure can be controlled in most people.

What Is Menopause?

 — Menopause is a normal part of aging for women, but it affects every woman differently.

Memory, Forgetfulness, and Aging: What’s Normal and What’s Not?

 — As you age, you may wonder about the difference between normal, age-related forgetfulness and a serious memory problem, such as dementia.

Shingles 

— Shingles is a disease that triggers a painful skin rash. About one in three people will get shingles, but there is a vaccine for older adults to help prevent the disease.

Vitamins and Minerals for Older Adults

 — Vitamins and minerals are types of nutrients that your body needs to survive and stay healthy.

Aging: ‘Healthy Longevity’ Journal – November 2022

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Inside the November 2022 Issue:

Research & review on #Alzheimers, global burden of benign prostatic hyperplasia, #WHO def of vitality capacity, IPD meta on social connection &  #cognition#oralhealth for older people & more.


Hope on the horizon for Alzheimer’s disease treatment?

Social connectedness and cognitive decline

Time to take oral health seriously

Aging: How Regenerative Medicine Slows The Clock

“Diverse aging populations, vulnerable to chronic disease, are at the cusp of a promising future. Indeed, growing regenerative options offer opportunities to boost innate healing, and address aging-associated decline. The outlook for an extended well-being strives to achieve health for all,”

Andre Terzic, M.D., Ph.D., a Mayo Clinic cardiologist

Regenerative medicine could slow the clock on degenerative diseases that often ravage the golden years, a Mayo Clinic study finds. Life span has nearly doubled since the 1950s, but health span — the number of disease-free years — has not kept pace. According to a paper published in NPJ Regenerative Medicine., people are generally living longer, but the last decade of life is often racked with chronic, age-related diseases that diminish quality of life. These final years come with a great cost burden to society.

Researchers contend that new solutions for increasing health span lie at the intersection of regenerative medicine research, anti-senescent investigation, clinical care and societal supports. A regenerative approach offers hope of extending the longevity of good health, so a person’s final years can be lived to the fullest.

Read more

Fall 2022: ‘Rejuvenating The Aging Brain’ – Scripps Research Magazine Cover

REJUVENATING THE AGING BRAIN

As humans live longer, they’re at increased risk of developing devastating NEURODEGENERATIVE diseases, such as Alzheimer’s—in a treatment landscape with few options and little hope. At Scripps Research, scientists are closer than ever to understanding how these diseases harm the brain and identifying possible drugs to stop them.

“This early preclinical work may identify proteins that protect against cognitive loss. We know it’s a long path to get to a drug, but we’re creating the foundation. We know there’s an entire landscape of potential molecular interactions that maintain healthy synapses, and any of these proteins could be a drug target.”— Hollis Cline, PhD

Website

Aging: How Biomarkers Help Diagnose Dementia

Biomarkers are measurable indicators of what’s happening in your body. They can be found in blood, other body fluids, organs, and tissues, and can be used to track healthy processes, disease progression, or even responses to a medication. Biomarkers are an important part of dementia research.

Read more

Old Age: ‘Hyperexcitable Neurons’ Interrupt Sleep

For many older adults, a good night’s rest is elusive. The implications of chronically poor sleep can be far-reaching and include a decline in cognitive functioning and detrimental effects on health and general well-being. Fortunately, relief may be in sight.

A new study led by investigators at the Stanford University School of Medicine shows that neurons in the lateral hypothalamus, a brain region, play a pivotal role in sleep loss in old mice. More specifically, the arousal-promoting hypocretin neurons become hyperexcitable, driving sleep interruptions.

Read the full story: https://stan.md/3JQ7z77

Luis de Lecea, PhD, is a professor of psychiatry and behavioral sciences at Stanford Medicine. He is the study’s senior author and hopes the finding could pave the way to new drug treatments for age-related sleep problems in humans.

Shi-Bin Li, PhD, is an instructor in the Psychiatry and Behavioral Sciences department at Stanford Medicine. He is also a basic life research scientist in the de Lecea lab, and is the lead author of the study.

Preview: New Scientist Magazine – July 2, 2022

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How readily should we swallow the idea of diets that delay ageing?

The promise of a new diet that can add as much as a decade to your life is certainly tempting – and might well be proven to work – but for now should be swallowed with a pinch of salt

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