The New Yorker – September 11, 2023 issue: The new issue features Dana Goodyear on editing humans with crispr, Elizabeth Kolbert on decoding whale communication, James Wood on George Eliot, and more.

The Transformative, Alarming Power of Gene Editing

A rogue scientist showed that crispr gives humans the ability to transform ourselves. But should we?

By Dana Goodyear

Crispr, which may be the single most transformative biological technology of the twenty-first century, is a natural phenomenon, evolved over billions of years. It was first observed in the nineteen-eighties, when researchers noticed unexplained sequences of viral DNA in E. coli. Eventually, they realized that these sequences played a role in the bacteria’s immune system: they could find and destroy other pieces of viral DNA. 

The Holy Heresies of George Eliot

Her greatest rebellion against Victorian moralism was to reclaim the sacred for herself.

By James Wood

Literature bores me, especially great literature,” the narrator of one of John Berryman’s “Dream Songs” says. George Eliot sometimes bores me, especially the George Eliot draped in greatness. Think of the extremities of nineteenth-century fiction: labile Lermontov; crazy, visionary Melville; nasty, world-hating Flaubert; mystic moor-bound Brontës; fanatical, trembling Dostoyevsky; explosive Hamsun. There’s enough wildness to destroy the myth of that stable Victorian portal “classic realism.” It was not classic—certainly not then—and not always particularly “real.”