Tag Archives: CRISPR

Science: What Is CRISPR And How Does It Work?

This revolutionary gene-editing system has taken science by storm. CRISPR is the basis of a revolutionary gene editing system. One day, it could make it possible to do everything from resurrect extinct species to develop cures for chronic disease.

CRISPR is a family of DNA sequences found in the genomes of prokaryotic organisms such as bacteria and archaea. These sequences are derived from DNA fragments of bacteriophages that had previously infected the prokaryote. They are used to detect and destroy DNA from similar bacteriophages during subsequent infections. 

CRISPR Technology: Dr. Jennifer Doudna On Its Medical Ethics (Video)

Dr. Jennifer Doudna first made her name uncovering the basic structure and function of the first ribozyme, a type of catalytic ribonucleic acid (RNA) that helps catalyse chemical reactions. This work helped lay the foundation for her later helping to pioneer CRISPR-Cas 9, a tool that has provided the means to edit genes on an unprecedented scale and at minimal cost. In addition to her scientific contributions to CRISPR, Doudna is known for spearheading the public debate to consider the ethical implications of using CRISPR-Cas9 to edit human embryos.

Interviews: Nobel Prize Biochemist Jennifer Doudna – ‘Code Breaker’

Visionary biochemist Jennifer Doudna shared the Nobel Prize last year for the gene-editing technology known as CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats), which has the potential to cure diseases caused by genetic mutations. Correspondent David Pogue talks with Doudna about the promises and perils of CRISPR; and with Walter Isaacson, author of the new book “The Code Breaker,” about why the biotech revolution will dwarf the digital revolution in importance.

Top Interviews: Jennifer A. Doudna & Emmanuelle Charpentier, 2020 Nobel Prize, Chemistry (Podcast)

“We had a sense that we were onto something big,” says Jennifer Doudna, as she recalls the start of her “curiosity-driven” research into CRISPR and reflects on the pace of the field today, in this short conversation with Adam Smith. Speaking from her patio in the early morning in Palo Alto, Doudna describes how she was woken by a call from a journalist: “I assumed she was calling me to ask me to comment on somebody else winning the Nobel Prize!” The award of the prize to her and Emmanuelle Charpentier will, she hopes, be an encouragement to other women. “Sometimes,” she comments, “there’s a sense that no matter what they do, their work will not be recognised in the way it would be if they were a man.”

In this interview recorded shortly after news broke of her Nobel Prize in Chemistry, Emmanuelle Charpentier tells Adam Smith of her surprise at receiving the call from Stockholm, despite considerable speculation that it might be coming her way. She speaks of the “explosion of knowledge and publications” that the CRISPR field has generated, the motivations behind her “brief but intense” collaboration with her co-Laureate Jennifer Doudna, the need for societal involvement in the conversation about the applications of technology and the importance of studying the microbiological world.

Science Podcast: Prussian Blue Structures, Extinct Rodents And Quantum Entanglement (Nature)

Nature PodcastsHear the latest from the world of science, brought to you by Nick Howe and Shamini Bundell. This week, uncovering the structure of materials with useful properties, and quantum entanglement over long distances.

In this episode:

00:45 Analysing Prussian blues

Analogues of the paint pigment Prussian blue are used in a variety of chemical processes. Now, researchers have uncovered their atomic structure. Research Article: Simonov et al.News and Views: Ordered absences observed in porous framework materials

08:17 Research Highlights

Teenagers’ natural sleep cycles impact on academic performance, and an extinct, giant rodent with a surprisingly tiny brain. Research Highlight: A teenager’s body clock can ring in school successResearch Highlight: Giant extinct rodent was all brawn and little brain

10:49 Distant entanglement

Researchers have demonstrated quantum entanglement between two points separated by 50 km of fibre optic cables. Research Article: Yu et al.

17:17 News Chat

The latest on the coronavirus outbreak, and gene editing gets an upgrade. News: Coronavirus: latest news on spreading infectionNews: Super-precise CRISPR tool enhanced by enzyme engineering

Science Podcasts: CRISPR & Immunotherapy, Ice Age Cave Art Dated With Wasp Nests (ScienceMag)

scimag_pc_logo_120_120 (2)On this week’s show, Staff Writer Jennifer Couzin-Frankel joins host Sarah Crespi to talk about Science paper that combines two hot areas of research—CRISPR gene editing and immunotherapy for cancer—and tests it in patients.

Sarah also talks with Damien Finch, a Ph.D. candidate in the School of Earth Sciences at the University of Melbourne, about the Kimberly region of Australia and dating its ice age cave paintings using charcoal from nearby wasp nests.

Website

Research: Scientists Find Protein To Regulate Immune Attacks, Reduce Rheumatoid Arthritis

From a New Atlas online article:

1200px-Karolinska_Institutet_seal.svgScientists have just discovered a new mechanism that can be key in regulating these immune attacks, raising new hopes of drugs that can protect against joint inflammation and the ailments it can bring.

Through the use of the CRISPR gene-editing tool, the Karolinska Institutet scientists have now shed further light on the role they play in inflammation. The technology enabled the team to make adjustments to a set of hand-picked immune cell genes as a way of learning how those tweaks can impact the behavior of the cells.

“The results we obtained using CRISPR were key to quickly understanding how the system under study is regulated,” says Dr Wermeling. “I have high hopes that the experimental use of CRISPR will be hugely important to our understanding of how immune-cell behavior is regulated, and that this can guide us in the development of new efficacious drugs.”

https://newatlas.com/medical/newly-understood-protein-raises-hopes-of-advanced-arthritis-treatments/?utm_source=New+Atlas+Subscribers&utm_campaign=68b0bd3225-EMAIL_CAMPAIGN_2020_01_21_02_40&utm_medium=email&utm_term=0_65b67362bd-68b0bd3225-93002753