Health Studies: Aspirin Use 3+ Times Per Week Reduces “All-Cause” Cancers In Older Adults (JAMA)

December 9, 2019 She Seeks Serene Leave a comment

From a JAMA Open Network online release:

This cohort study included 146 152 individuals from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial and found that aspirin use 3 or more times per week was associated with reduced risk of all-cause, cancer, gastrointestinal cancer, and colorectal cancer mortality.

Importance Aspirin use has been associated with reduced risk of cancer mortality, particularly of the colorectum. However, aspirin efficacy may be influenced by biological characteristics, such as obesity and age. With the increasing prevalence of obesity and conflicting data regarding the effect of aspirin in older adults, understanding the potential association of aspirin use with cancer mortality according to body mass index (BMI) and age is imperative.

Objectives To investigate the association of aspirin use with risk of all-cause, any cancer, gastrointestinal (GI) cancer, and colorectal cancer (CRC) mortality among older adults and to perform an exploratory analysis of the association of aspirin use with mortality stratified by BMI.

Design, Setting, Participants This cohort study evaluated aspirin use among participants aged 65 years and older in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial at baseline (November 8, 1993, to July 2, 2001) and follow-up (2006-2008). Analysis began in late 2018 and was completed in September 2019.

Arts & Literature, Books, Profiles

Artist Profiles: Film Director Mike Nichols (1931-2014) Profiled In New Book (NY Times Podcast)

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Mike Nichols, who died in 2014, was a film and stage director of genius, and he wasted no time in showing it. The first two films he directed were “Who’s Afraid of Virginia Woolf?” and “The Graduate.” In the new oral history “Life Isn’t Everything,” Ash Carter and Sam Kashner draw on 150 respondents to tell the story of his incredible career.

Website: https://www.nytimes.com/2019/12/06/books/review/podcast-life-isnt-everything-mike-nichols-still-here-elaine-stritch-alexandra-jacobs.html

Classics, Reviews, Transportation

Classic Car Nostalgia: “1968 Triumph TR6” – 1st Year (Classic Driver)

December 9, 2019 She Seeks Serene Leave a comment

From a Classic Driver online listing:

Offered as an affordable, six-cylinder sports car, the first Triumph TR6 rolled off the production line in 1968 as a 1969 model. It’s intended target was to rival similar sports cars at the time, and although most were designed with sleek, curved lines, the TR6 was squared off at both ends, making it stand out from it’s competitors. With just a seven year production span, the TR6 grew to become a true British classic.

The Triumph TR6 was offered as a convertible only, with a factory steel hard top available optionally.

Triumph produced a range of TR models, from the TR1 right up to a limited run of the TR8, but it was the sixth car in the range that really stood out from a sales point of view. The TR5 enjoyed a very brief thirteen-month period of manufacture between 1967 and 1968. Less than 3,000 units were produced before the TR6 came in to improve on many of the specifications. Unlike its predecessors, the Triumph TR6 was more reliable mechanically, which means that there are many original models still on our roads.

Website: https://www.classicdriver.com/en/car/triumph/tr6/1968/723270

Health, Studies

Healthcare Studies: High Level Of Depression Symptoms In Physicians Linked To Medical Errors

December 9, 2019 She Seeks Serene Leave a comment

From a JAMA Network online release:

This systematic review and meta-analysis of 11 studies involving 21 517 physicians demonstrated an association between physician depressive symptoms and an increased risk for perceived medical errors (RR, 1.95; 95% CI, 1.63-2.33). We also found that the magnitude of the associations of physician depressive symptoms and perceived medical errors were relatively consistent across studies that assessed training and practicing physicians, providing additional evidence that physician depression has implications for the quality of care delivered by physicians at different career stages.

Medical errors are a major source of patient harm. Studies estimate that, in the United States, as many as 98 000 to 251 000 hospitalized patients die each year as result of a preventable adverse event.¹^–4 In addition, medical errors are a major source of morbidity⁵ and account for billions of dollars in financial losses to health care systems every year.⁶^–9

Depressive symptoms are highly prevalent among physicians,¹⁰^,11 and several studies have investigated the associations between physician depressive symptoms and medical errors.¹²^–16 Although most studies on physician depressive symptoms and medical errors have identified a substantial association, their results are not unanimous, and questions regarding the direction of these associations remain open in recent literature.¹⁷

Aging, Science, Technology

Genetic Engineering: Harvard Scientist George Church Seeks To “Reverse Aging” (60 Minutes Video)

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Our lives have been transformed by the information age. But what’s coming next is likely to be more profound, call it the genetic information age. We have mapped the human genome and in just the last few years we have learned to read and write DNA like software. And you’re about to see a few breakthroughs-in-waiting that would transform human health. For a preview of this revolution in evolution we met George Church, a world leading geneticist, whose own DNA harbors many eccentricities and a few genes for genius.

Website: https://www.cbsnews.com/news/harvard-geneticist-george-church-goal-to-protect-humans-from-viruses-genetic-diseases-and-aging-60-minutes-2019-12-08/