From a Sleep Review Magazine online article:
When people are awake during the night, their behaviors are often mismatched with their internal body clocks. This can lead to nighttime eating, which can influence the way the body processes sugar and could lead to a higher risk in diabetes. “What happens when food is eaten when you normally should be fasting?” Scheer asked the audience. “What happens is that your glucose tolerance goes out the window….So your glucose levels after a meal are much higher.” This can increase people’s risk for diabetes.
Frank Scheer, PhD, professor of medicine at Harvard Medical School and director of the medical chronobiology program at Brigham and Women’s Hospital in Boston, says disruption of the body’s circadian rhythms may be one major reason why more Americans are living with preventable diseases. During his keynote talk at the 2019 AAST annual meeting in St. Louis, he outlined how recent research supports the hypothesis that higher rates of shiftwork and other forms of nighttime disruption could be contributing to increased rates of obesity, diabetes, and other common ailments.
To read more: http://www.sleepreviewmag.com/2019/10/circadian-rhythm-disruption-increase-preventable-diseases/
From a Wall Street Journal online article:
The rapid aging of the population, together with high rates of obesity and diabetes in all ages, are pushing both the rate and number of deaths from heart failure higher, the study said. Most deaths from heart failure occur in older Americans, but they are rising in adults under 65, too, the study showed.
The findings help explain why a decadeslong decline in the death rate from cardiovascular disease has slowed substantially since 2011 and started rising in middle-aged people, helping drive down U.S. life expectancy.
Deaths from heart failure, one of the nation’s biggest killers, are surging as the population ages and the health of younger generations worsens.
The death rate from the chronic, debilitating condition rose 20.7% between 2011 and 2017 and is likely to keep climbing sharply, according to a study published Wednesday in the journal JAMA Cardiology.
To read more: https://www.wsj.com/articles/heart-failure-deaths-rise-contributing-to-worsening-life-expectancy-11572411901
From a ScienceDaily.com online release:
Physical inactivity, smoking, high blood pressure, diabetes, and high cholesterol play a greater role than genetics in many young patients with heart disease, according to research presented today at ESC Congress 2019 together with the World Congress of Cardiology. The findings show that healthy behaviours should be a top priority for reducing heart disease even in those with a family history of early onset.
The study enrolled 1,075 patients under 50, of whom 555 had coronary artery disease (known as premature CAD). Specific conditions included stable angina, heart attack, and unstable angina. The average age was 45 and 87% were men. Risk factor levels and genetics in patients were compared to a control group of 520 healthy volunteers (average age 44, and 86% men). Patients and controls were recruited from the Genes in Madeira and Coronary Disease (GENEMACOR) database.
Five modifiable risk factors were assessed: physical inactivity, smoking, high blood pressure, diabetes, and high cholesterol. Nearly three-quarters (73%) of patients had at least three of these risk factors compared to 31% of controls. In both groups, the likelihood of developing CAD increased exponentially with each additional risk factor. The probability of CAD was 3, 7, and 24 times higher with 1, 2, and 3 or more risk factors, respectively.
To read more: https://www.sciencedaily.com/releases/2019/09/190902181602.htm
From the journal Circulation on August 19, 2019:
The use of n-3 FA (4 g/d) for improving atherosclerotic cardiovascular disease risk in patients with hypertriglyceridemia is supported by a 25% reduction in major adverse cardiovascular events in REDUCE-IT (Reduction of Cardiovascular Events With EPA Intervention Trial), a randomized placebo-controlled trial of EPA-only in high-risk patients treated with a statin.
The results of a trial of 4 g/d prescription EPA+DHA in hypertriglyceridemia are anticipated in 2020. We conclude that prescription n-3 FAs (EPA+DHA or EPA-only) at a dose of 4 g/d (>3 g/d total EPA+DHA) are an effective and safe option for reducing triglycerides as monotherapy or as an adjunct to other lipid-lowering agents.
Hypertriglyceridemia (triglycerides 200–499 mg/dL) is relatively common in the United States, whereas more severe triglyceride elevations (very high triglycerides, ≥500 mg/dL) are far less frequently observed. Both are becoming increasingly prevalent in the United States and elsewhere, likely driven in large part by growing rates of obesity and diabetes mellitus.
To read more click on the following link: https://www.ahajournals.org/doi/10.1161/CIR.0000000000000709
From a Rutgers Today online article:
The study found that brown fat could also help the body filter and remove branched-chain amino acids (BCAAs) from the blood. BCAAs (leucine, isoleucine and valine) are found in foods like eggs, meat, fish, chicken and milk, but also in supplements used by some athletes and people who want to build muscle mass.
In normal concentrations in the blood, these amino acids are essential for good health. In excessive amounts, they’re linked to diabetes and obesity. The researchers found that people with little or no brown fat have reduced ability to clear BCAAs from their blood, and that may lead to the development of obesity and diabetes.
Rutgers and other scientists have discovered how brown fat, also known as brown adipose tissue, may help protect against obesity and diabetes. Their study in the journal Nature adds to our knowledge about the role of brown fat in human health and could lead to new medications for treating obesity and type 2 diabetes.
To read more click on the following link: https://news.rutgers.edu/scientists-discover-why-brown-fat-good-people%E2%80%99s-health/20190819#.XV6imuhKhPZ
From The Lancet Diabetes & Endocrinology:
This joint position statement from the International Atherosclerosis Society and the International Chair on Cardiometabolic Risk Working Group on Visceral Obesity summarises the evidence for visceral adiposity and ectopic fat as emerging risk factors for type 2 diabetes, atherosclerosis, and cardiovascular disease, with a focus on practical recommendations for health professionals and future directions for research and clinical practice.
Findings from epidemiological studies over the past 30 years have shown that visceral adipose tissue, accurately measured by CT or MRI, is an independent risk marker of cardiovascular and metabolic morbidity and mortality. Emerging evidence also suggests that ectopic fat deposition, including hepatic and epicardial fat, might contribute to increased atherosclerosis and cardiometabolic risk. We discuss the measurement of visceral and ectopic fat, pathophysiology and contribution to adverse health outcomes, response to treatment, and lessons from a public health programme targeting visceral and ectopic fat. We identify knowledge gaps and note the need to develop simple, clinically applicable tools to be able to monitor changes in visceral and ectopic fat over time. Finally, we recognise the need for public health messaging to focus on visceral and ectopic fat in addition to excess bodyweight to better combat the growing epidemic of obesity worldwide.
To read more click on the following link: https://www.thelancet.com/journals/landia/article/PIIS2213-8587(19)30084-1/fulltext?dgcid=raven_jbs_etoc_email
From an International Journal of Obesity July 2019 study:
This study, combined with the results of previous studies, supports the hypothesis that engaging in morning exercise may result in more weight loss compared to engaging in a similar amount of exercise later in the day. Furthermore, we observed individuals who performed most of their exercise sessions in the afternoon or evening tended to have slightly higher levels of EI and reduced NEPA and NEEx, suggesting that there are potentially important differences in the components of energy balance based on time of day exercise is performed.
Circadian physiology has been linked to body weight regulation and obesity. To date, few studies have assessed the association between exercise timing and weight related outcomes. The aim of this secondary analysis was to explore the impact of exercise timing (i.e., 24 h clock time of exercise session) on weight loss and components of energy balance.
To read more click on following link: https://www.nature.com/articles/s41366-019-0409-x