nature video (March 15, 2023) – Lymphocytes are immune cells that play vital roles in fighting infections. The most well-known lymphocytes are the T cells and B cells of the adaptive immune system. In the 1950s and 1960s, scientists performed experiments to follow lymphocytes on their journey around the body, which helped us to work out where they go and what they do.
This work laid the foundation for everything we know about T cells today, including how they become activated to fight infections and how they form memory populations that provide long-lasting immunity.
National Science Foundation (March 13, 2023) – Harnessing the power of AI, researchers calculate our brain’s age leading to earlier detection of Alzheimer’s and other cognitive diseases.
Researchers at USC have developed a new artificial intelligence model that more accurately captures brain age. This study could result in earlier detection of Alzheimer’s and other cognitive diseases and provide important information about how quickly our brains age.
“It’s extremely important we as health care professionals address diabetes, poor sleep and poor sleep hygiene, and obesity as they are modifiable risk factors for cardiovascular disease,” says Nishant P. Shah, MD, FACC, a preventive cardiologist at Duke Heart Center, Duke University School of Medicine, in Durham, NC.
Obesity, diabetes and sleep-disordered breathing (SDB) are considered to be extant and growing public health crises. A wealth of information links these conditions to each other and to increased morbidity, reduced quality of life and death. While managing these conditions that often occur together may be challenging for patients and clinicians, successfully addressing them represents a real opportunity to reduce cardiovascular disease and prevent cardiovascular events.
New blood tests can reveal whether your immune system is fighting fit by looking at the balance of different immune cells, but there may be a simpler way of gauging your immune health
Banded mongooses have long been used as a model of animal cooperation. Now, researchers in Uganda are starting to get to grips with the harsh realities of their long-running and bloody battles
In some cases, it is now possible to genetically engineer the immune system to banish cancers like T-cell leukaemia that were previously unresponsive to treatments
“Even more importantly, we’ve shown you can collect the blood drop at home and mail it into the lab,” saidMichael Snyder, PhD, director of the Center for Genomics and Personalized Medicine and senior author on the research, which was published in Nature Biomedical Engineering on Jan. 19.
Unlike finger-prick testing for diabetes, which measures a single type of molecule (glucose), multi-omics microsampling gives data about thousands of different molecules at once.
A single drop of blood can yield measurements for thousands of proteins, fats and other biomarkers, researchers at Stanford Medicine found.
The new approach combines a microsampling device — a tool used to self-administer a finger prick — with “multi-omics” technologies, which simultaneously analyze a vast array of proteins, fats, by-products of metabolism and inflammatory markers.
Harvard Medical School – A 13-year international study in mice demonstrates that loss of epigenetic information, which influences how DNA is organized and regulated, can drive aging independently of changes to the genetic code itself.
It also shows that restoring the integrity of the epigenome reverses age-related symptoms.
Our new position paper with @worldheartfed summarises the relationship between obesity and cardiovascular disease (#CVD) mortality.
World Obesity Federation (January 2023) – The ongoing obesity epidemic represents a global public health crisis that contributes to poor health outcomes, reduced quality of life, and >2.8 million deaths each year. Obesity is relapsing, progressive, and heterogeneous. It is considered a chronic disease by the World Obesity Federation (WOF) and a chronic condition by the World Heart Federation (WHF).
People living with overweight/obesity are at greater risk for cardiovascular (CV) morbidity and mortality. Increased adiposity (body fat), particularly visceral/abdominal fat, is linked to CV risk and CV disease (CVD) via multiple direct and indirect pathophysiological mechanisms. The development of CVD is driven, in part, by obesity-related metabolic, endocrinologic, immunologic, structural, humoral, haemodynamic, and functional alterations.
The Lancet (January 2023) – For our 200th anniversary year we have identified five Spotlight subjects of particular importance. Watch as Richard Horton, Editor-in-Chief, and other Lancet Editors around the world outline these Spotlights and discuss priorities for the future of health.
This year, we draw attention to the most critical issues impacting health globally, the extraordinary people involved in tackling them, and the voices of those most impacted. For five Spotlights, we will run a programme of activities to bring these issues to life and convene the right people and resources in order to drive change in these areas.
Freethink – Robotics are helping make minimally invasive surgeries even less invasive. Case in point: single-port robotic surgery, a relatively new type of approach where a robotic system controlled by a human surgeon executes the procedure by making only one incision into the patient.
Although still relatively uncommon, single-port surgery has been gaining momentum in recent years. The benefits are noticeable. Compared to traditional surgery, single-port surgery might leave patients with shorter recovery times, less scarring, and overall better outcomes.
The technique is also transforming how surgeons think about and execute surgery itself. “It’s allowing us to do surgeries differently than we do with [multi-port surgery],” said Michael Stifelman, M.D., director of robotic surgery at Hackensack University Medical Center. “What every patient wants is to get back to their life. Single-port robotics is allowing us to get them to that point more quickly.”
Learn more about the future of single-port surgery in this episode of “Operation: Reimagine Surgery,” a Freethink original series produced in partnership with Intuitive, which created the world’s first commercially available robotic surgery system in the 1990s.
Daniela Hernandez | WSJ – Getting the flu can increase the risk of getting a second infection, including strep throat. WSJ’S Daniela Hernandez explains the science behind that, plus what it means for the rest of the winter and how we can protect ourselves so the tripledemic doesn’t get worse.
Video timeline: 0:24 – Flu Damage 1:25 – Lower population immunity 2:03 – Who’s most vulnerable? 3:05 – How can we protect ourselves?