Chloroquine was shown in 2004 to be active in vitro against SARS coronavirus but is of unproven efficacy and safety in patients infected with SARS-CoV-2. The drug’s potential benefits and risks for COVID-19 patients, without and with azithromycin, is discussed by Dr. David Juurlink, head of the Division of Clinical Pharmacology and Toxicology at Sunnybrook Health Sciences Centre in Toronto.
From Wall Street Journal article:
Our experience suggests that hydroxychloroquine, with or without a Z-Pak, should be a first-line treatment. Unfortunately, there is already a shortage of hydroxychloroquine. The federal government should immediately contract with generic manufacturers to ramp up production. Any stockpiles should be released.
As a matter of clinical practice, hydroxychloroquine should be given early to patients who test positive, and perhaps if Covid-19 is presumed—in the case of ill household contacts, for instance. It may be especially useful to treat mild cases and young patients, which would significantly decrease viral transmission and, as they say, “flatten the curve.”
BBC Radio 4 speaks to Petina Gappah on her new book, “Out of Darkness, Shining Light”.
Underappreciated in her lifetime, the career of late Irish architect and designer Eileen Gray is the subject of a timely new exhibition at The Bard Graduate Center Gallery in New York. Jennifer Goff, curator of the Eileen Gray collection at the National Museum of Ireland, tells us more.
On this week’s show, host Joel Goldberg talks with science journalist Andrew Curry about archaeological finds from thousands of years ago along the shores of Northern Europe. Curry outlines the rich history of the region that scientists, citizen scientists, and energy companies have helped dredge up.
Listen to the latest from the world of science, brought to you by Benjamin Thompson and Nick Howe. This week, Nautre speaks to Rosamund Pike about her experience portraying Marie Skłodowska Curie, and we find out how science in Russia is changing after years of decline.
In this episode, Sidney talks about how Gemini GEL got started and grew into the organization it is today, sharing stories about the artists he’s worked with along the way.
In 1966, at the age of forty-one, Sidney Felsen moved from the world of accounting to that of art, founding the artists’ workshop and fine-art print publisher Gemini GEL in Los Angeles. With Gemini GEL, Sidney quickly got to work with some of the biggest artists of the twentieth century: Man Ray, Josef Albers, Jasper Johns, and Robert Rauschenberg, to name a few. And Gemini GEL continues its work with new generations of artists, including Julie Mehretu, Tacita Dean, and David Hammons.
Monocle’s Charlie Jermyn talks us through the rich and varied culinary delights on offer in Ireland’s second city.
Nathan Pritikin was a college dropout who became an entrepreneur. While doing research for the government during World War II, he observed that populations that had extremely limited food availability because of the war had substantially reduced mortality from cardiovascular disease—something unexpected at a time when cardiovascular disease was thought to be due to stress. 
Robert Bound, John Mitchinson and Ted Hodgkinson review the final – and rather hefty – instalment of Hilary Mantel’s Thomas Cromwell trilogy.
Boomers Daily 