Category Archives: Diet

New Study: “Five Healthy Habits” For Diet, Exercise, BMI, Smoking & Alcohol” Lower Chronic Disease, Raise Lifespan (Harvard)

From a BMJ online article:

We derived a healthy lifestyle score based on information on five lifestyle factors—diet, smoking, physical activity, alcohol consumption, and body mass index (BMI).

Harvard T.H. Chan School of Public Health LogoOur findings suggest that promotion of a healthy lifestyle would help to reduce the healthcare burdens through lowering the risk of developing multiple chronic diseases, including cancer, cardiovascular disease, and diabetes, and extending disease-free life expectancy. Public policies for improving food and the physical environment conducive to adopting a healthy diet and lifestyle, as well as relevant policies and regulations (for example, smoking ban in public places or trans-fat restrictions), are critical to improving life expectancy, especially life expectancy free of major chronic diseases.

The average life expectancy in the world has increased substantially in the past few decades. The aging of the population has led to a high prevalence of chronic diseases such as diabetes, cardiovascular disease, and cancer. Although people live longer, older individuals often live with disabilities and chronic diseases. People with chronic diseases including cancer, cardiovascular disease, and diabetes have a shorter life expectancy than do their peers without these chronic conditions. Estimates of the loss in life years due to these chronic conditions range from 7.5 to 20 years, depending on the methods used and the characteristics of the study population.

Life Expectancy In Men and Women with Five Healthy Habits BMJ Study Harvard Medical 2020
Estimated life expectancy at age 50 years with and without cancer, cardiovascular disease (CVD), and/or type 2 diabetes among participants of Nurses’ Health Study (women) and Health Professionals Follow-up Study (men) according to levels of individual lifestyle risk factors. Estimates of multivariate adjusted hazard ratios (sex specific) for morbidity and mortality associated with low risk lifestyles compared with people with zero low risk lifestyle factors adjusted for age, ethnicity, current multivitamin use, current aspirin use, family history of diabetes, myocardial infarction, or cancer, and menopausal status and hormone use (women only). AHEI=Alternate Healthy Eating Index; BMI=body mass index; F=fifth. *Cigarettes/day. †Hours/week. ‡Grams/day

Modifiable lifestyle factors including smoking, physical activity, alcohol intake, body weight, and diet quality affect both total life expectancy and incidence of chronic diseases. Studies have shown that smoking, inactivity, poor diet quality, and heavy alcohol consumption contribute up to 60% of premature deaths and 7.4-17.9 years’ loss in life expectancy. Nevertheless, little research has looked at how a combination of multiple lifestyle factors may relate to life expectancy free from the major diseases of diabetes, cardiovascular disease, and cancer.

Read full study

Fasting Activates Sirtuin Signaling Proteins (SIRT1), Accelerating Cell Repair

Sirtuins are a family of signaling proteins involved in metabolic regulation. SIRT1 (along with SIRT6 and SIRT7) are proteins are employed in DNA repair.

 

Sirtuins - SIRT1 Activator Nature Reviews Drug Discovery

From Wikipedia:

Sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. The name Sir2 comes from the yeast gene ‘silent mating-type information regulation 2‘, the gene responsible for cellular regulation in yeast.

From in vitro studies, sirtuins are implicated in influencing cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. As of 2018, there was no clinical evidence that sirtuins affect human aging.

Aging

Although preliminary studies with resveratrol, an activator of deacetylases such as SIRT1, led some scientists to speculate that resveratrol may extend lifespan, there was no clinical evidence for such an effect, as of 2018.

In vitro studies shown that calorie restriction regulates the plasma membrane redox system, involved in mitochondrial homeostasis, and the reduction of inflammation through cross-talks between SIRT1 and AMP-activated protein kinase (AMPK), but the role of sirtuins in longevity is still unclear, as calorie restriction in yeast could extend lifespan in the absence of Sir2 or other sirtuins, while the in vivo activation of Sir2 by calorie restriction or resveratrol to extend lifespan has been challenged in multiple organisms.

 

Studies: Disrupted Sleep Cycles & Dopamine Linked; Craving “High-Calorie Food” & Obesity Are Result

From a NeuroscienceNews.com online release article (01/02/20):

During the years 1976 through 1980, 15% of U.S. adults were obese. Today, about 40%of adults are obese. Another 33% are overweight.

“But, of course, food is now abundant, and our next meal is as close as the kitchen, or the nearest fast-food drive-through, or right here on our desk. Often, these foods are high in fats, sugars, and therefore calories, and that’s why they taste good. It’s easy to overconsume, and, over time, this takes a toll on our health.”

Current Biology Journal Dopamine Signaling and Weight Gain January 2 2020
Dopamine Signaling in the Suprachiasmatic Nucleus Enables Weight Gain Associated with Hedonic Feeding – Current Biology January 2, 2020

Read full study

In a study published Thursday in the journal Current Biology, Güler and his colleagues demonstrate that the pleasure center of the brain that produces the chemical dopamine, and the brain’s separate biological clock that regulates daily physiological rhythms, are linked, and that high-calorie foods – which bring pleasure – disrupt normal feeding schedules, resulting in overconsumption. Using mice as study models, the researchers mimicked the 24/7 availability of a high-fat diet, and showed that anytime snacking eventually results in obesity and related health problems.

Read more

Healthy Diets: “The Science Behind Fasting – Ketosis” (Infographic)

The Science Behind Fasting - Ketosis
Cellular Cleanup Crew Fasting and caloric restriction both can ramp up autophagy, a kind of cellular housekeeping. When cells are in famine mode and don’t have to break down food, they pause their usual tasks and stop dividing. Instead, they work on repairing and recycling damaged components, and cleaning out dead or harmful cell matter. Alison Mackey/Discover

…It seems fasting triggers a dramatic switch in the body’s metabolism, according Discover Magazine logoto a paper Mattson and colleagues published in February in the experimental biology journal FASEB. In humans, fasting for 12 hours or more drops the levels of glycogen, a form of cellular glucose. Like changing to a backup gas tank, the body switches from glucose to fatty acids, a more efficient fuel. The switch generates the production of ketones, which are energy molecules that are made in the liver. “When the fats are mobilized and used to produce ketones, we think that is a key factor in accruing the health benefits,” says Mattson.

Read more at Discover Magazine

Aging: “Okinawa’s Secrets To Longevity” (Telegraph)

The Telegraph logoHundreds of miles south of Japan’s main islands, in the East China Sea, is a Jurassic Park of longevity, with a higher percentage of centenarians (people who live to 100 years old) than anywhere else on Earth.

Greg Dickinson visits the Japanese archipelago of Okinawa to discover the secret to long life.

Read the full article at: https://telegraph.co.uk/travel/destin…

Health: 60-Year Old “B-D” Editor Launches “18-Hour Intermittent Fasting” Diet Study For 2020’s Decade

Following the important publishing of “The Benefits Of Intermittent Fasting” study by Johns Hopkins in the New England Journal of Medicine on December 26, 2019, the 60-year old editor of Boomers-Daily.com (“B-D”) will launch, participate in, and document a decade-long, 18-Hour Intermittent Fasting Diet on December 30, 2019. The following protocol will be followed:

  • All daily food consumption will be between 10 am and 4 pm
  • Diet will be followed 7 days a week
  • High fiber, nutrition-dense foods will be favored
  • Gluten-free and Lactose-free foods will be favored
  • Eating will NOT be calorie-restricted
  • Bedtime target of 7:30 to 8:30 pm (or earlier) every night
  • 7-8+ hours of sleep per night a PRIORITY
  • Early morning vigorous exercise daily of 1 – 1 1/2 hours targeted

All readers of Boomers-Daily.com are encouraged to communicate with B-D and launch their own 18-hour Intermittent Fasting Diet (the 6-hour eating period can be varied 1-2 hours later or earlier). Please email boomersdaily@gmail.com to join the study, comment or inquire about this or your own 18-Hour Intermittent Fasting Diet. We will be looking to start an online chat room and other online platforms to increase the size, scope, visibility and transparency of the study over the next decade.

12-26-19  Intermittent Fasting: Live ‘Fast,’ Live longer? (infographic).png.png

New Studies: Beneficial Effects Of “18-Hour Intermittent Fasting” On Health And Aging (NEJM)

From a New England Journal of Medicine online release:

In humans, intermittent-fasting interventions ameliorate obesity, insulin resistance, dyslipidemia, hypertension, and inflammation. Intermittent fasting seems to confer health benefits to a greater extent than can be attributed just to a reduction in caloric intake.

Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, increased longevity, and a decreased incidence of diseases, including cancer and obesity.

The New England Journal of Medicine Logo

Preclinical studies and clinical trials have shown that intermittent fasting has broad-spectrum benefits for many health conditions, such as obesity, diabetes mellitus, cardiovascular disease, cancers, and neurologic disorders. Animal models show that intermittent fasting improves health throughout the life span, whereas clinical studies have mainly involved relatively short-term interventions, over a period of months.

Effects of Intermittent Fasting on Health, Aging, and Disease New England Journal of Medicine December 26 2019

BOOMERS-DAILY.COM “18-HOUR INTERMITTENT FASTING DIET” STUDY

How much of the benefit of intermittent fasting is due to metabolic switching and how much is due to weight loss? Many studies have indicated that several of the benefits of intermittent fasting are dissociated from its effects on weight loss. These benefits include improvements in glucose regulation, blood pressure, and heart rate; the efficacy of endurance training; and abdominal fat loss.

To read more

Inline image