Nearly 100 years since insulin was first used in the treatment of diabetes, Professor Chantal Mathieu, Professor of Medicine at the Katholieke Universiteit Leuven, Belgium, takes us through the history, development and future of this life saving drug. Read more in https://www.nature.com/articles/d4285…
Visionary biochemist Jennifer Doudna shared the Nobel Prize last year for the gene-editing technology known as CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats), which has the potential to cure diseases caused by genetic mutations. Correspondent David Pogue talks with Doudna about the promises and perils of CRISPR; and with Walter Isaacson, author of the new book “The Code Breaker,” about why the biotech revolution will dwarf the digital revolution in importance.
In 1972, Frank Wilczek and his thesis adviser, David Gross, discovered the basic theory of the strong force — the final pillar of the Standard Model of particle physics. Their work revealed the strange alchemy at work inside the nucleus of an atom. It also turned out to underpin almost all subsequent research into the early universe. Wilczek and Gross went on to share the 2004 Nobel Prize in Physics for the work. At the time it was done, Wilczek was just 21 years old. His influence in the decades since has been profound. He predicted the existence of a hypothetical particle called the axion, which today is a leading candidate for dark matter. He published groundbreaking papers on the nature of the early universe. And just last year, his prediction of the “anyon” — a strange type of particle that only shows up in two-dimensional systems — was experimentally confirmed.
Cecilia Gralde in Stockholm speaks to this year’s Nobel Laureates in Peace, Physics, Chemistry, Physiology or Medicine, and Economic Sciences about the theories, discoveries and research behind their awards, and the value of science in dealing with the global pandemic.SHOW LESS
“He was the advisor everybody recommended you should have,” says Paul Milgrom of Robert Wilson, his PhD supervisor and now near neighbour in Palo Alto and co-Laureate in Economic Sciences. In this conversation with Adam Smith, recorded 20 minutes after Milgrom had learned of his prize, he describes how it was Wilson who actually delivered the news, in person: “He and his wife just walked over and rang the doorbell.”
Not only are the 2020 Economics Science Laureates long-time collaborators, they are also neighbours in Palo Alto, and so when Robert Wilson heard the news of his prize from Stockholm, he simply crossed the street and knocked on Paul Milgrom’s door to wake him! “It sounds like something from the nineteenth century,” says Wilson in this conversation with Adam Smith, recorded shortly after the news became public. He describes his pride at the fact that Milgrom is the third of his students, after Alvin Roth and Bengt Holmström, to be awarded the prize, a perfect combination of events that he calls his “trifecta”.
“We had a sense that we were onto something big,” says Jennifer Doudna, as she recalls the start of her “curiosity-driven” research into CRISPR and reflects on the pace of the field today, in this short conversation with Adam Smith. Speaking from her patio in the early morning in Palo Alto, Doudna describes how she was woken by a call from a journalist: “I assumed she was calling me to ask me to comment on somebody else winning the Nobel Prize!” The award of the prize to her and Emmanuelle Charpentier will, she hopes, be an encouragement to other women. “Sometimes,” she comments, “there’s a sense that no matter what they do, their work will not be recognised in the way it would be if they were a man.”
In this interview recorded shortly after news broke of her Nobel Prize in Chemistry, Emmanuelle Charpentier tells Adam Smith of her surprise at receiving the call from Stockholm, despite considerable speculation that it might be coming her way. She speaks of the “explosion of knowledge and publications” that the CRISPR field has generated, the motivations behind her “brief but intense” collaboration with her co-Laureate Jennifer Doudna, the need for societal involvement in the conversation about the applications of technology and the importance of studying the microbiological world.
Listen to the latest from the world of science, brought to you by Benjamin Thompson and Nick Howe. This week, Nautre speaks to Rosamund Pike about her experience portraying Marie Skłodowska Curie, and we find out how science in Russia is changing after years of decline.
In this episode:
British actor Rosamund Pike tells us about her new film, and her experience of portraying double Nobel-Laureate Marie Curie. Arts Review: Marie Curie biopic should have trusted pioneer’s passion
10:17 Research Highlights
12:27 Russian science
Decades after the collapse of the Soviet Union, Russian science may be having a revival. News Feature: Russia aims to revive science after era of stagnation; Editorial: The price of Russia–China research collaborations
Interview with the 2019 Nobel Laureate in Chemistry John B. Goodenough, 6 December 2019
0:07 – What advice would you give to a younger version of yourself? 0:32 – How do you recognise a good teacher? 0:58 – Do you see yourself as a mentor now? 1:33 – What qualities do you think you need to be a successful scientist? 3:04 – How do you cope with failure? 3:16 – How has your dyslexia shaped you? 3:44 – How important has nature been for you? 4:40 – Has music played an important role in your life? 5:06 – How did your interest in poetry start? 6:14 – How did you meet your wife? 7:06 – What life advice can you share? 8:30 – How do you remember so much of your life? 8:47 – How does it feel to be back in Stockholm after 80 years? 9:21 – How has living through World War II influenced you? 10:03 – What is your relationship with your lab colleagues? 11:18 – What are the characteristics of a very good team? 11:55 – What is your relationship with Akira Yoshino? 12:28 – How has the scientific landscape has changed over the years? 13:42 – What environment encourage creative thinking? 14:48 – What research are you working on now? 15:39 – What are your thoughts on sustainability? 16:37 – What future do you see for sustainable batteries?
John Bannister Goodenough born July 25, 1922) is an American materials scientist, a solid-state physicist, and a Nobel laureate in chemistry. He is a professor of mechanical engineering and materials science at the University of Texas at Austin. He is widely credited with the identification and development of the lithium-ion battery, for developing the Goodenough–Kanamori rules in determining the sign of the magnetic superexchange in materials, and for seminal developments in computer random access memory.
Sir Peter and Prof. Kaelin were awarded the Nobel Prize in Physiology and Medicine last year by the Nobel Assembly at Karolinska Institutet, in recognition of their discoveries of how cells sense and adapt to oxygen availability, an essential adaptive process central to many significant diseases. The professors respectively work for the University of Oxford and Harvard University, and shared the Nobel Prize with Prof. Gregg Semenza, a fellow researcher.
In this interview from the Nobel Banquet on 10 December 2019, Literature Laureate Olga Tokarczuk talks about her childhood dream of being a scientist, curiosity as motivation and the importance of translators.
Olga Tokarczuk, (born January 29, 1962, Sulechów, Poland), Polish writer who was known for her wry and complex novels that leap between centuries, places, perspectives, and mythologies. She received the 2018 Nobel Prize for Literature (awarded belatedly in 2019), lauded for her “narrative imagination that with encyclopedic passion represents the crossing of boundaries as a form of life.” A best-selling author in Poland for decades, Tokarczuk was not well known outside her homeland until she became the country’s first author to win the Man Booker International Prize in 2018 for Flights (2017)—the English translation of her sixth novel, Bieguni (2007).