From a Newcastle University news release:
“When fat cannot be safely stored under the skin, it is then stored inside the liver, and over-spills to the rest of the body including the pancreas. This ‘clogs up’ the pancreas, switching off the genes which direct how insulin should effectively be produced, and this causes Type 2 diabetes.”
This latest paper builds on previous Newcastle studies supported by Diabetes UK showing exactly why Type 2 diabetes can be reversed back to normal glucose control. Those studies led to the large DiRECT trial which showed that Primary Care staff can achieve remission of Type 2 diabetes by using a low calorie diet with support to maintain the weight loss.
A quarter of participants achieved a staggering 15 kg or more weight loss, and of these, almost nine out of 10 people put their Type 2 diabetes into remission. After two years, more than one third of the group had been free of diabetes and off all diabetes medication for at least two years.
In 2020, this approach to management of short duration Type 2 diabetes is to be piloted in the NHS in up to 5,000 people across England, and a similar programme is being rolled out in Scotland.
From a Cell Metabolism online study release:
Ten-hour time-restricted eating (TRE) limits daily dietary intake to a consistent 10-h window, creating a 14-h nightly fast. Researchers studied whether TRE for 12 weeks in people with metabolic syndrome receiving standard medical care (including medications to lower cholesterol and blood pressure) improves markers of health. TRE led to weight loss, healthier body composition (including decreased waist circumference), lower blood pressure and levels of cardiovascular disease-promoting lipids (i.e., “bad cholesterol” levels), and more restful sleep. TRE could be an effective dietary intervention to help those with metabolic syndrome.
Time-restricted eating (TRE) is an emerging dietary intervention that aims to maintain a consistent daily cycle of feeding and fasting to support robust circadian rhythms (Panda, 2016). Circadian regulation of the endocrine system, autonomic nervous system, and nutrient metabolism contributes to metabolic and physiological homeostasis (Asher and Sassone-Corsi, 2015,Panda, 2016). Both erratic eating patterns and eating over an extended period of time during the 24-h day can disrupt circadian rhythms.
To read entire study: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30611-4
From a Harvard news release:
…a new study from the Harvard John A. Paulson School for Engineering and Applied Sciences (SEAS) and Harvard’s Wyss Institute for Biologically Inspired Engineering has found that an orally administered liquid salt called Choline and Geranate (CAGE) can physically reduce the absorption of fats from food with no discernible side effects in rats, and reduces total body weight by about 12 percent.
“A reduction in body weight of 12 percent is like getting a human from 200 pounds down to 176, which is a significant change,” said first author Md Nurunnabi, a former Postdoctoral Fellow at the Wyss Institute and SEAS who is now an Assistant Professor of Pharmaceutical Sciences at The University of Texas at El Paso. “Our goal is to translate this work into a product that can help people maintain a healthier weight, and this study marks the very beginning of that journey.”
CAGE, which is a salt in its liquid state, was created a few years ago by Samir Mitragotri, the Hiller Professor of Bioengineering and Hansjörg Wyss Professor of Biologically Inspired Engineering, as part of an effort to improve the body’s absorption of medicines.
From an International Journal of Obesity July 2019 study:
This study, combined with the results of previous studies, supports the hypothesis that engaging in morning exercise may result in more weight loss compared to engaging in a similar amount of exercise later in the day. Furthermore, we observed individuals who performed most of their exercise sessions in the afternoon or evening tended to have slightly higher levels of EI and reduced NEPA and NEEx, suggesting that there are potentially important differences in the components of energy balance based on time of day exercise is performed.
Circadian physiology has been linked to body weight regulation and obesity. To date, few studies have assessed the association between exercise timing and weight related outcomes. The aim of this secondary analysis was to explore the impact of exercise timing (i.e., 24 h clock time of exercise session) on weight loss and components of energy balance.
To read more click on following link: https://www.nature.com/articles/s41366-019-0409-x
“Prospective analysis of 1986 community-dwelling subjects (mean age 65 years, 47% females) with overweight/obesity and metabolic syndrome from the PREDIMED-Plus trial was conducted…
Our findings suggest that the less variability in sleep duration or an adequate sleep duration the greater the success of the lifestyle interventions in adiposity.”
Click on Journal of Obesity to read article.