Tag Archives: Intermittent Fasting

Brain Health: The Benefits Of Intermittent Fasting

Although intermittent fasting is most widely known as a weight-loss strategy, emerging research suggests that it could have benefits for brain health and cognition. But does it actually work, are there any drawbacks and how long would you have to fast to see benefits? WSJ’s Daniela Hernandez breaks down what’s known and what’s not about the neuroscience of intermittent fasting.

Timeline: 0:00 Could intermittent fasting help our brains work better and longer? 0:31 How long would you have to fast to see any potential cognitive benefits? 1:04 How intermittent fasting could affect your ability to focus 2:27 Potential mood-related benefits of intermittent fasting 2:48 How intermittent fasting can affect brain health 4:03 Potential drawbacks of intermittent fasting

Healthy Diet Podcasts: “Spoon-Fed” Author & Professor Tim Spector

According to a recent study, obesity increases the risk of dying of Covid-19 by nearly 50%. Governments around the world are now hoping to encourage their citizens to lose weight. But with so much complex and often contradictory diet advice, as well as endless food fads, it can be hard to know what healthy eating actually looks like. 

How many pieces of fruit and vegetables should you eat a day? Will cutting out carbs help you lose weight? Is breakfast really the most important meal of the day? Speaking to Tim Spector, professor of genetic epidemiology at King’s College London about his new book Spoon-Fed, Madeleine Finlay asks why we’re still getting food science wrong, and explores the current scientific evidence on snacking, supplements and calorie labels. 

Tim Spector is a Professor of Genetic Epidemiology and Director of the TwinsUK Registry at Kings College, London and has recently been elected to the prestigious Fellowship of the Academy of Medical Sciences. He trained originally in rheumatology and epidemiology. In 1992 he moved into genetic epidemiology and founded the UK Twins Registry, of 13,000 twins, which is the richest collection of genotypic and phenotypic information worldwide. He is past President of the International Society of Twin Studies, directs the European Twin Registry Consortium (Discotwin) and collaborates with over 120 centres worldwide. He has demonstrated the genetic basis of a wide range of common complex traits, many previously thought to be mainly due to ageing and environment. Through genetic association studies (GWAS), his group have found over 500 novel gene loci in over 50 disease areas. He has published over 800 research articles and is ranked as being in the top 1% of the world’s most cited scientists by Thomson-Reuters. He held a prestigious European Research Council senior investigator award in epigenetics and is a NIHR Senior Investigator. His current work focuses on omics and the microbiome and directs the crowdfunded British Gut microbiome project. Together with an international team of leading scientists including researchers from King’s College London, Massachusetts General Hospital, Tufts University, Stanford University and nutritional science company ZOE he  is conducting the largest scientific nutrition research project, showing that individual responses to the same foods are unique, even between identical twins. You can find more on https://joinzoe.com/ He is a prolific writer with several popular science books and a regular blog, focusing on genetics, epigenetics and most recently microbiome and diet (The Diet Myth). He is in demand as a public speaker and features regularly in the media.

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Health: The Benefits Of “Intermittent Fasting” For People In High-Stress Jobs

From Oxford University Press – OUP (May 1, 2020):

…ultra-processed foods are generally the foods available to nurses working nightshifts, firefighters returning to their department after a call, police officers Intermittent Fasting Article in OUP May 1 2020patrolling neighborhoods, or military soldiers during field-exercises. Thus, time-restricted eating removes the added stress of what to eat, and serves as a practical intervention conducive to the schedules of many people.

Time-restricted eating has been shown to lower circulating insulin, blood pressure, body fat and overall body weight, inflammation, and oxidative stress.

Time-restricted eating is a nutrition intervention which alternates between a period of fasting (12 – 16 hours) followed by a period of eating (8 – 12 hours). Unlike other diets, which focus on the caloric content of a meal or which foods you should eat, time-restricted eating focuses exclusively on when you eat by compressing and standardizing the feeding window each day. In turn, people following this type of eating pattern naturally enter a state of caloric deficit.

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Nutrition Reviews - Time-Restricted Feeding

Read Study in Nutrition Reviews

Diet: “Skeptical” NY Times Health Writer Endorses Numerous Health Benefits Of 16+ Hour Fasting

From a New York Times article by Jane E. Brody (Feb 17, 2020):

“It takes 10 to 12 hours to use up the calories in the liver before a metabolic shift occurs to using stored fat,” Dr. Mattson told me. After meals, glucose is used for energy and fat is stored in fat tissue, but during fasts, once glucose is depleted, fat is broken down and used for energy.

The Benefits of Intermittent Fasting Jane E Brody New York Times February 17 2020I was skeptical, but it turns out there is something to be said for practicing a rather prolonged diurnal fast, preferably one lasting at least 16 hours. Mark P. Mattson, neuroscientist at the National Institute on Aging and Johns Hopkins University School of Medicine, explained that the liver stores glucose, which the body uses preferentially for energy before it turns to burning body fat.

For example, human studies of intermittent fasting found that it improved such disease indicators as insulin resistance, blood fat abnormalities, high blood pressure and inflammation, even independently of weight loss. In patients with multiple sclerosis, intermittent fasting reduced symptoms in just two months, a research team in Baltimore reported in 2018.

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Mayo Clinic Health: “Obesity Epidemic And Popular Diet Trends”

On the Mayo Clinic Radio program, Dr. Donald Hensrud, director of the Mayo Clinic Healthy Living Program, discusses the obesity epidemic and talks about popular diet trends, including intermittent fasting.

This interview originally aired Feb. 8, 2020.

Learn more about intermittent fasting: https://www.mayoclinic.org/healthy-li…

Podcast: “Intermittent Fasting” Study Author Mark P. Mattson MD On Diet’s Health Benefits

NEJM Journal WatchIntermittent fasting has salutary effects. Listen how Dr. Mark P. Mattson, co-author of a recent NEJM review on the topic, assesses the practice — and how he’s managed to skip breakfast for the past 30 years or so.

Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, increased longevity, and a decreased incidence of diseases, including cancer and obesity.

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Fasting Activates Sirtuin Signaling Proteins (SIRT1), Accelerating Cell Repair

Sirtuins are a family of signaling proteins involved in metabolic regulation. SIRT1 (along with SIRT6 and SIRT7) are proteins are employed in DNA repair.

 

Sirtuins - SIRT1 Activator Nature Reviews Drug Discovery

From Wikipedia:

Sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. The name Sir2 comes from the yeast gene ‘silent mating-type information regulation 2‘, the gene responsible for cellular regulation in yeast.

From in vitro studies, sirtuins are implicated in influencing cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. As of 2018, there was no clinical evidence that sirtuins affect human aging.

Aging

Although preliminary studies with resveratrol, an activator of deacetylases such as SIRT1, led some scientists to speculate that resveratrol may extend lifespan, there was no clinical evidence for such an effect, as of 2018.

In vitro studies shown that calorie restriction regulates the plasma membrane redox system, involved in mitochondrial homeostasis, and the reduction of inflammation through cross-talks between SIRT1 and AMP-activated protein kinase (AMPK), but the role of sirtuins in longevity is still unclear, as calorie restriction in yeast could extend lifespan in the absence of Sir2 or other sirtuins, while the in vivo activation of Sir2 by calorie restriction or resveratrol to extend lifespan has been challenged in multiple organisms.

 

Healthy Diets: “The Science Behind Fasting – Ketosis” (Infographic)

The Science Behind Fasting - Ketosis
Cellular Cleanup Crew Fasting and caloric restriction both can ramp up autophagy, a kind of cellular housekeeping. When cells are in famine mode and don’t have to break down food, they pause their usual tasks and stop dividing. Instead, they work on repairing and recycling damaged components, and cleaning out dead or harmful cell matter. Alison Mackey/Discover

…It seems fasting triggers a dramatic switch in the body’s metabolism, according Discover Magazine logoto a paper Mattson and colleagues published in February in the experimental biology journal FASEB. In humans, fasting for 12 hours or more drops the levels of glycogen, a form of cellular glucose. Like changing to a backup gas tank, the body switches from glucose to fatty acids, a more efficient fuel. The switch generates the production of ketones, which are energy molecules that are made in the liver. “When the fats are mobilized and used to produce ketones, we think that is a key factor in accruing the health benefits,” says Mattson.

Read more at Discover Magazine

Health: 60-Year Old “B-D” Editor Launches “18-Hour Intermittent Fasting” Diet Study For 2020’s Decade

Following the important publishing of “The Benefits Of Intermittent Fasting” study by Johns Hopkins in the New England Journal of Medicine on December 26, 2019, the 60-year old editor of Boomers-Daily.com (“B-D”) will launch, participate in, and document a decade-long, 18-Hour Intermittent Fasting Diet on December 30, 2019. The following protocol will be followed:

  • All daily food consumption will be between 10 am and 4 pm
  • Diet will be followed 7 days a week
  • High fiber, nutrition-dense foods will be favored
  • Gluten-free and Lactose-free foods will be favored
  • Eating will NOT be calorie-restricted
  • Bedtime target of 7:30 to 8:30 pm (or earlier) every night
  • 7-8+ hours of sleep per night a PRIORITY
  • Early morning vigorous exercise daily of 1 – 1 1/2 hours targeted

All readers of Boomers-Daily.com are encouraged to communicate with B-D and launch their own 18-hour Intermittent Fasting Diet (the 6-hour eating period can be varied 1-2 hours later or earlier). Please email boomersdaily@gmail.com to join the study, comment or inquire about this or your own 18-Hour Intermittent Fasting Diet. We will be looking to start an online chat room and other online platforms to increase the size, scope, visibility and transparency of the study over the next decade.

12-26-19  Intermittent Fasting: Live ‘Fast,’ Live longer? (infographic).png.png

New Studies: Beneficial Effects Of “18-Hour Intermittent Fasting” On Health And Aging (NEJM)

From a New England Journal of Medicine online release:

In humans, intermittent-fasting interventions ameliorate obesity, insulin resistance, dyslipidemia, hypertension, and inflammation. Intermittent fasting seems to confer health benefits to a greater extent than can be attributed just to a reduction in caloric intake.

Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, increased longevity, and a decreased incidence of diseases, including cancer and obesity.

The New England Journal of Medicine Logo

Preclinical studies and clinical trials have shown that intermittent fasting has broad-spectrum benefits for many health conditions, such as obesity, diabetes mellitus, cardiovascular disease, cancers, and neurologic disorders. Animal models show that intermittent fasting improves health throughout the life span, whereas clinical studies have mainly involved relatively short-term interventions, over a period of months.

Effects of Intermittent Fasting on Health, Aging, and Disease New England Journal of Medicine December 26 2019

BOOMERS-DAILY.COM “18-HOUR INTERMITTENT FASTING DIET” STUDY

How much of the benefit of intermittent fasting is due to metabolic switching and how much is due to weight loss? Many studies have indicated that several of the benefits of intermittent fasting are dissociated from its effects on weight loss. These benefits include improvements in glucose regulation, blood pressure, and heart rate; the efficacy of endurance training; and abdominal fat loss.

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