Tag Archives: Brains

Research Preview: Science Magazine – Nov 4, 2022


Science Magazine – Brain connectivity

No neuron is an island

The brain is so much more than its constituent cells. Each neuron in the brain connects with thousands of other neurons—but instead of a cacophony of connections, we have a synchronized symphony.

Atlas-based data integration for mapping the connections and architecture of the brain

Detailed knowledge about the neural connections among regions of the brain is key for advancing our understanding of normal brain function and changes that occur with aging and disease.

Solving brain circuit function and dysfunction with computational modeling and optogenetic fMRI

Can we construct a model of brain function that enables an understanding of whole-brain circuit mechanisms underlying neurological disease and use it to predict the outcome of therapeutic interventions?

Scale matters: The nested human connectome

The emergent properties of the connected brain

Brain Health: The Benefits Of Intermittent Fasting

Although intermittent fasting is most widely known as a weight-loss strategy, emerging research suggests that it could have benefits for brain health and cognition. But does it actually work, are there any drawbacks and how long would you have to fast to see benefits? WSJ’s Daniela Hernandez breaks down what’s known and what’s not about the neuroscience of intermittent fasting.

Timeline: 0:00 Could intermittent fasting help our brains work better and longer? 0:31 How long would you have to fast to see any potential cognitive benefits? 1:04 How intermittent fasting could affect your ability to focus 2:27 Potential mood-related benefits of intermittent fasting 2:48 How intermittent fasting can affect brain health 4:03 Potential drawbacks of intermittent fasting

Diet & Nutrition: Nine Tips For A Healthier Brain

• Find time to snack healthily. Take short food breaks to help keep your blood-sugar level reasonably high without surging. Eating a piece of fruit every three hours or so, for example, could prevent hunger and overconsumption of calories. And when you eat, relax. Try not to think about your research. If you routinely stand in the lab, sit down. If your role is more sedentary, get up and take a quick stroll — perhaps to see a colleague on the next floor.

• Put food on your agenda. Schedule regular mealtimes in your work diary — because if you don’t, someone else will fill the gap for you by inviting you to a meeting. Choose a slot that aligns with your ‘biological clock’ and alterations in hormones such as insulin to optimize metabolic health, including microbiota diversity and composition. In other words, follow your gut and eat at times of the day when you feel that your body needs it, but generally try to avoid taking lunch too late in the afternoon. Eating earlier in the day can improve your energy balance, weight regulation, glycaemic control and sleep satisfaction6. Your brain consumes about 20% of the total energy used by your body, so maintaining consistent energy levels is important for optimal functioning. Use the time you’ve booked. Focus on what you eat and take your time. Do not grab a sandwich and munch it down in front of a screen. Your body deserves a rest.

• Enjoy your food. Transform your meal break into a pleasant event by sharing it with colleagues. Propose that everyone take turns preparing a dish from their home country or area so that you can all enjoy the cuisines of different cultures. Eating in a group and discussing the day’s events can help you to relax, to laugh and to share useful information and experiences.

• Plan your meals. If you are feeling particularly hungry, your eyes and hypothalamus (a small region in the brain that controls many bodily functions including hunger and thirst) will not help you to make healthy food choices; instead, they will prompt you to go for sugary, salty or fatty options. Try to organize your meals in advance. Increase your intake of low-calorie items, such as soups, salads, vegetables and minimally processed foods that are rich in dietary fibre. Among these are wholegrains, cereals, fruits, pulses, whole rice and wholemeal pasta. These foods are also rich in micronutrients and antioxidants such as potassium, magnesium, vitamin C, vitamin E, B-vitamins and healthy lipids — especially unsaturated omega-3 ones — that can help to prevent chronic disease. Neurotransmitters such as serotonin, dopamine, epinephrine and norepinephrine — all important for good brain function, mood and emotional regulation — require food-derived precursors, as well as vitamins and minerals, to be synthesized7.

• Diversify your diet. Stimulate your appetite by altering your food choices, preferably by incorporating more fruit and vegetables into your diet and reducing consumption of red meat and meat products. Each new day merits a new meal experience. But this doesn’t mean being a fully fledged connoisseur: overthinking what you eat will lead to compromises with your time and will make further compromises in what you eat more tempting. A saying from the Japanese Okinawa islands, where people have one of the lowest rates of chronic diseases in the world, and where many centenarians live, points the way: “Eat until you are 80% full”8. In practice, this means you should eat slowly and avoid ‘stuffing’ yourself.

• Avoid the insulin roller coaster. As well as contributing to chronic disease, excessive sugar intake might harm cognitive performance9. Sugared drinks, such as sodas, smoothies and even fruit juices, have a very low satiety value. After the sugar surge, glucagon — a hormone produced when sugar levels are low — as well as ghrelin, an appetitive hormone, and others kick back in and you’ll be hypoglycaemic and feel hungry again. Artificially sweetened beverages might not work much better — there is scientific debate about their perceived health benefits, because they might stimulate appetite centrally in the hypothalamus, rather than by modulating insulin levels10. Go for water, coffee, teas (including fruit teas), low-fat milk — or, if you’re desperate for sugar, a homemade fruit juice.

• Drink loads of water. Working inside, where the air is often dry (owing to heating in winter and artificial cooling in summer) can hasten water loss through respiration. Two litres a day of fluid intake is recommended by many health agencies. Pay attention to signs of dehydration. Drinking plenty will increase your blood volume and brain tissue fluid and thus boost your circulation and concentration levels. You will also become more tolerant of heat and cold — which is helpful when working in warm offices and cooled labs. Water is the essential carrier for all life functions in your body. It can also increase daily energy expenditure and feelings of satiety. Drinking water half an hour before your meal is an especially good option because it improves satiety11.

• Use healthy leftovers. Pre-packaged sandwiches and processed foods often have high quantities of fat, sugar, salt and additives that trigger the brain’s dopamine reward system, among other neuronal systems, inducing compulsive eating behaviour12. If you have time, prepare a healthy dish from scratch at home, perhaps making more than is needed for an evening meal and using leftovers for lunch the following day. Among homemade foods, well-balanced traditional dishes can improve your performance and health: for instance, the classic Mediterranean diet has long been linked with improved cognitive function and a decreased likelihood of both cognitive impairment and Alzheimer’s disease3. A Tupperware lunch made with leftovers from even the most indulgent dinner could often make a healthier lunch than a standard pre-packaged sandwich.

• Scrap the salt. Excessive use of salt is among the major killers worldwide, leading to increased blood pressure, stroke and other cardiovascular diseases. Some salt is essential to the taste of most foods, as well as for life, however, so don’t attempt to cut it out of your diet entirely. Try pepper, curcuma, nutmeg or other spices to add flavour. Some spices, including curcuma and pepper, also help to lower the risk of cardiovascular disease and can even decrease total mortality rates13.

Science Magazine: “Why We Sleep” – October 29

Analysis: How Do Video Games, Smartphones & Computers Affect Brains

Smartphones, computers, gaming consoles or digital tablets are now givens in our daily lives. The electronic intrusion is causing controversy and collective hysteria. This documentary asks: Are we damaging our brains with all these screens? How will unprecedented exposure to screens impact humanity?

To find out, the filmmakers examine how science has been applied to distinguish between truth and falsehoods, and explore the suspected side-effects of screen exposure. The documentary travels through the US and Europe to meet and speak to researchers who are leaders in this field.

Science Podcast: Views Of Magnetars, When Human Brains Got Complex

Host Sarah Crespi talks with Contributing Correspondent Joshua Sokol about magnetars—highly magnetized neutron stars. A recent intense outburst of gamma rays from a nearby galaxy has given astronomers a whole new view on these mysterious magnetic monsters. 

Also on this week’s show, Christoph Zollikofer, a professor of anthropology at the University of Zurich, talks about the evolution of humanlike brains. His team’s work with brain-case fossils suggests the complex brains we carry around today were not present in the early hominins to leave Africa, but later developed in the cousins they left behind. 

New Research Podcasts: “Human Brains Are Wired To Enjoy Musical Pitch”

The Scientist PodcastsIn this month’s episode, we learn that human brains differentiate musical pitch a way that macaque monkeys do not. In fact, speech and music shaped the human brain’s hearing circuits. Researchers are studying these circuits with an eye on developing treatments for neurological disorders. 


Health Infographics: How Exercise Creates “New Neurons In Aging Brains”

New Neurons in Aging Brains Scientific American January 2020 Tami Tolpa

Scientific American logo

Researchers have also documented clear links between aerobic exercise and benefits to other parts of the brain, including expansion of the prefrontal cortex, which sits just behind the forehead. Such augmentation of this region has been tied to sharper executive cognitive functions, which involve aspects of planning, decision-making and multitasking—abilities that, like memory, tend to decline with healthy aging and are further degraded in the presence of Alzheimer’s. Scientists suspect that increased connections between existing neurons, rather than the birth of new neurons, are responsible for the beneficial effects of exercise on the prefrontal cortex and other brain regions outside the hippocampus.

Scientific American article