Science Magazine – December 14, 2023: The new issue cover features The 2023 Breakthrough of the Year: Obesity meets its match – Blockbuster weight loss drugs show promise for a wider range of health benefits; Runners-Up: At last, modest headway against Alzheimer’s; and Breakdowns of the Year – What went wrong in the world of Science….
Obesity meets its match
Blockbuster weight loss drugs show promise for a wider range of health benefits
Obesity plays out as a private struggle and a public health crisis. In the United States, about 70% of adults are affected by excess weight, and in Europe that number is more than half. The stigma against fat can be crushing; its risks, life-threatening. Defined as a body mass index of at least 30, obesity is thought to power type 2 diabetes, heart disease, arthritis, fatty liver disease, and certain cancers.
At last, modest headway against Alzheimer’s
Medicine has had little to offer the tens of millions of people worldwide with Alzheimer’s disease, and the few approved treatments have only targeted symptoms. But in January, U.S. regulators greenlit the first drug that clearly, if modestly, slows cognitive decline by tackling the disease’s underlying biology; a second, related treatment is close behind. Neither comes close to a cure, and both have serious risks, but they offer new hope to patients and families.