Dr. Nilüfer Ertekin-Taner, neurogeneticist and behavioral neurologist, discusses characteristics of neurodegenerative diseases such as dementia, Alzheimer’s disease, and movement disorders. She also discusses her research on the complex genetics of Alzheimer’s disease, including identifying therapeutic targets and biomarkers. She highlights Mayo Clinic’s unique approach to patient care.
From the Journal of Sport and Health Science:
Therefore, promotion of adequate volumes and intensities of physical exercise (i.e., approximately 3 months of moderate-intensity aerobic exercise, with 2–3 sessions/week lasting not less than 30 min) represents an inexpensive and safe strategy for boosting BDNF (brain-derived neurotrophic factor) release that may preserve or restore cognitive function.
Taken together, the currently available data seemingly confirm the existence of a positive relationship between physical exercise and circulating BDNF levels, both in the short and long term, and also support the beneficial impact of training programs for amplifying the acute BDNF response.
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From a University of Toronto Medicine article:
“There are two important takeaways from this paper. One is that poor sleep is associated with brain immune dysregulation or dysfunction,” says Lim, the corresponding author for the paper.
“The second part is that dysfunction appears to be further associated with impaired cognition.”
The study shows that in adults with fragmented sleep – where people were waking up repeatedly instead of sleeping soundly – there was an effect on microglia, and the cells showed signs of accelerated aging and other abnormalities.
The researchers were then able to identify that these changes in the microglia could be associated with worse cognition in older adults, both with and without Alzheimer’s disease.
To read full study: https://advances.sciencemag.org/content/5/12/eaax7331
To read more: https://medicine.utoronto.ca/news/research-suggests-fragmented-sleep-may-affect-brain-s-immune-cells-impair-cognition
From a MedicalXpress.com online release:
Researchers suggest that intensity is critical. Seniors who exercised using short, bursts of activity saw an improvement of up to 30 percent in memory performance while participants who worked out moderately saw no improvement, on average.
Researchers at McMaster University who examine the impact of exercise on the brain have found that high-intensity workouts improve memory in older adults.