From a MedPage Today online article (April 2, 2020):
This relationship between higher glucose levels and poorer cognitive functioning extended beyond just CASI z-score, as well, Cukierman-Yaffe noted. Higher HbA1c levels were also tied to significantly poorer performance in other psychological tests, including the clock making test of executive functioning, test of discriminative ability, and for the test of verbal fluency.
Poorer glycemic control was tied to cognitive decline following a lacunar stroke in a prospective cohort study.
Among 942 individuals with type 2 diabetes who had a lacunar stroke, every 1% higher HbA1c was tied to a 0.06 drop in cognitive function at baseline measured by Cognitive Assessment Screening Instrument (CASI) z-score (95% CI -0.101 to -0.018), reported Tali Cukierman-Yaffe, MD, MSc, of Sheba Medical Center and the Sackler School of Medicine of Tel Aviv University in Israel.
Place your hands on the edge of a counter, just beyond shoulder-width apart. Lower into a push-up then press back up. Repeat 10 to 12 times. For more of a challenge, walk your feet farther away from the counter.
“These results are exciting, as they suggest that people may potentially prevent brain shrinking and the effects of aging on the brain simply by becoming more active,” said study author Yian Gu, Ph.D., of Columbia University in New York and a member of the American Academy of Neurology.
Well, when you get older, you are more fabulous, actually. You go through a lot of hard times in your life… and then, at this stage you get out of those bad situations quicker and they are less painful. You figure them out, and you move on. And I’m having the best time ever. I’m 71 now, it’s the best time ever, and I think at 81 it will be great. My mom [had] her best times when she was in her 90s. So I look forward to that.
Aspirin is an inhibitor of prostaglandin production and may influence the cellular basis of bone remodelling responsible for maintaining the material and structural strength of bone.
We suggest this increase in mortality seen on DR in the 4-day switch treatment is due to either accrued physiological costs or more probable, a carryover of deaths directly resulting from the rich diet, but recorded on the DR diet.
“I don’t have this precious career as an actor that I had to preserve. I’m an older guy, I’ve had a career, and the most personal thing I’ve ever done was Mr. Show, so, in a way I’ve said my piece, so I just don’t have all that much to lose really compared to somebody who’s an actor for a living and dreaming of their own show. My daughter asked me this question. This was a kid who grew up in Hollywood. She said, “If it’s bad, how bad would it be?” And I thought, Well, it’s Vince Gilligan and Peter Gould. The worst thing it would be, would be an experiment that just didn’t pan out, but an interesting one at the very least.”
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