On the Mayo Clinic Q&A podcast, Dr. Jessica Lancaster, a Mayo Clinic immunologist, discusses aging and the immune system. Some people are at higher risk of getting very sick from COVID-19 because of their age or underlying health conditions, according to the Centers for Disease Control and Prevention (CDC).
Adults 60 and older and those with an underlying health condition or a compromised immune system appear to develop serious illness more often than others. This interview was recorded March 19, 2020.
Learn more about immune system research at Mayo Clinic: https://www.mayo.edu/research/centers…
From a Science Magazine online article:
They found that these physically active mice had fewer inflammatory cells (leukocytes) than sedentary mice, an effect they traced to diminished activity of hematopoietic stem and progenitor cells (HSPCs). The lower activity of HSPCs was due at least in part to exercise-induced reduction in the levels of leptin, a hormone produced by fat tissue that regulates cells within the hematopoietic bone marrow niche.
Regular physical activity is associated with a lower rate of death from heart disease, but the underlying mechanisms are not fully understood. Frodermann et al. examined the effect of exercise on cardiovascular inflammation, a known risk factor for atherosclerosis, by studying mice that voluntarily ran for long distances on exercise wheels.
To read more: https://science.sciencemag.org/content/366/6469/1091.2
From a Genetic Engineering & Biotechnology News release:
“These results show quite clearly that there’s a very specific part of the brain network that’s affected by inflammation,” noted Mazaheri. “This could explain ‘brain fog’.”
Raymond added that “this research finding is a major step forward in understanding the links between physical, cognitive, and mental health and tells us that even the mildest of illnesses may reduce alertness.”
Researchers at the University of Birmingham’s Centre for Human Brain Health in collaboration with the University of Amsterdam say they have uncovered a possible explanation for the mental sluggishness that often accompanies illness. The team investigated the link between “mental fog” and inflammation, the body’s response to illness. In a study (“Selective effects of acute low-grade inflammation on human visual attention”) published in Neuroimage, they showed that inflammation appears to have a particularly negative impact on the brain’s readiness to reach and maintain an alert state.
To read more: https://www.genengnews.com/news/link-found-between-inflammation-and-mental-sluggishness/?utm_medium=newsletter&utm_source=GEN+Daily+News+Highlights&utm_content=01&utm_campaign=GEN+Daily+News+Highlights_20191118&oly_enc_id=5678C5137845J4Z
From a Harvard news online release:
“This study identifies a new molecular connection between exercise and inflammation that takes place in the bone marrow and highlights a previously unappreciated role of leptin in exercise-mediated cardiovascular protection,” said Michelle Olive, program officer at the National Heart, Lung, and Blood Institute Division of Cardiovascular Sciences. “This work adds a new piece to the puzzle of how sedentary lifestyles affect cardiovascular health and underscores the importance of following physical-activity guidelines.”
Scientists at Harvard-affiliated Massachusetts General Hospital (MGH) have identified a previously unknown biological pathway that promotes chronic inflammation and may help explain why sedentary people have an increased risk for heart disease and strokes.
In a study to be published in the November issue of Nature Medicine, MGH scientists and colleagues at several other institutions found that regular exercise blocks this pathway. This discovery could aid the development of new therapies to prevent cardiovascular disease.
To read more: https://news.harvard.edu/gazette/story/2019/11/exercise-found-to-block-chronic-inflammation-in-mice/