Health: Migraines Affects 47 Million Americans, 75% Of Whom Are Women (PBS)

Migraine disease affects 47 million Americans — 75 percent of whom are women. Although headache is one symptom, attacks can include visual disturbances, nausea, extreme light and sound sensitivity, brain fog and debilitating pain. Stigma and gender stereotypes may complicate the medical response, treatments aren’t one-size-fits-all and federal funding is minimal. Stephanie Sy reports.

Interviews: 56-Year Old Comedian, TV Host Conan O’Brien (Oxford Union)

Conan O’Brien is an American comedian and television personality, best known for hosting his own eponymous late-night talk show, Conan. A former writer for SNL and The Simpsons, and a graduate of Harvard University, he is celebrated for his awkward, self-deprecating comedic style, and has over 25 years’ experience as a late-night host.

Conan Christopher O’Brien (born April 18, 1963) is an American television host, comedian, writer, podcaster, and producer. He is best known for writing in Saturday Night Live and The Simpsons and hosting Late-night talk shows like Late Night with Conan O’Brien , The Tonight Show with Conan O’Brien and Conan. Since 2010, he has been hosting Conan on the cable channel TBS.

Born in Brookline, Massachusetts, O’Brien was raised in an Irish Catholic family. He served as president of The Harvard Lampoon while attending Harvard University, and was a writer for the sketch comedy series Not Necessarily the News. After writing for several comedy shows in Los Angeles, he joined the writing staff of Saturday Night Live. O’Brien was a writer and producer for The Simpsons for two seasons until he was commissioned by NBC to take over David Letterman’s position as host of Late Night in 1993. A virtual unknown to the public, O’Brien’s initial Late Night tenure received unfavorable reviews and remained on a multi-week renewal cycle during its early years. The show generally improved over time and was highly regarded by the time of his departure in 2009. Afterwards, O’Brien relocated from New York to Los Angeles to host his own incarnation of The Tonight Show for seven months until network politics prompted a host change in 2010.

(From Wikipedia)

ABOUT THE OXFORD UNION SOCIETY: The Oxford Union is the world’s most prestigious debating society, with an unparalleled reputation for bringing international guests and speakers to Oxford. Since 1823, the Union has been promoting debate and discussion not just in Oxford University, but across the globe.

Science Podcasts: Fruit Fly Neural Circuits, Fuzzy Moth Acoustics And Metallic Glass (Nature)

Nature PodcastsThis week, the brain pathways of egg laying in fruit flies, preventing fractures in metallic glass, moth’s fuzz as superior acoustic camouflage and a coronavirus update.

In this episode:

00:46 Working out the wiring behind fruit fly behaviour

Researchers have identified a neural circuit linking mating and egg laying in female fruit flies. Research Article: Wang et al.

06:01 Research Highlights

Ancient, cave-dwelling cockroaches, and hairy moths dampen sound. Research Highlight: Cockroaches preserved in amber are the world’s oldest cave dwellers; Research Highlight: Stealth flyers: moths’ fuzz is superior acoustic camouflage

07:57 Making better metallic glass

Metallic glasses have many desirable properties, but these materials are prone to fracturing. Now, a new manufacturing process may have overcome this issue. Research article: Pan et al.News and Views: Metallic glasses rejuvenated to harden under strain

13:47 News Chat

Coronavirus outbreak updates, a survey shows Indian bird numbers are in decline, and the genomes of New York rats. News: Coronavirus: latest news on spreading infectionNews: Hundreds of bird species in India are decliningNews: Genomes reveal how New York City’s rats thrive in the urban jungle

Digital Health: Wearable Sensor Data Can Predict Heart Failure 6 Days Before Hospitalization

From a “Circulation: Heart Failure” Journal study (Feb 25, 2020):

Circulation Heart Failure logoThe study shows that wearable sensors coupled with machine learning analytics have predictive accuracy comparable to implanted devices.

We demonstrate that machine learning analytics using data from a wearable sensor can accurately predict hospitalization for heart failure exacerbation…at a median time of 6.5 days before the admission.

Heart failure (HF) is a major public health problem affecting >23 million patients worldwide. Hospitalization costs for HF represent 80% of costs attributed to HF care. Thus, accurate and timely detection of worsening HF could allow for interventions aimed at reducing the risk of HF admission.

Data collected by the sensor are streamed to a phone and then encrypted and uploaded to a cloud analytics platform.
Data collected by the sensor are streamed to a phone and then encrypted and uploaded to a cloud analytics platform.

Several such approaches have been tested. Tracking of daily weight, as recommended by current HF guidelines, did not lead to reduction of the risk of HF hospitalization, most likely because the weight gain is a contemporaneous or lagging indicator rather than a leading event. Interventions based on intrathoracic impedance monitoring also did not result in reduction of readmission risk. The results suggest that physiological parameters other than weight or intrathoracic impedance in isolation may be needed to detect HF decompensation in a timely manner. In fact, 28% reduction of rehospitalization rates has been shown with interventions based on pulmonary artery hemodynamic monitoring. More recently, in the MultiSENSE study (Multisensor Chronic Evaluation in Ambulatory HF Patients), an algorithm based on physiological data from sensors in the implantable cardiac resynchronization therapy defibrillators, was shown to have 70% sensitivity in predicting the risk of HF hospitalization or outpatient visit with intravenous therapies for worsening of HF.

Read full study

Politics: “South Carolina Democratic Debate Recap”

Seven candidates took the stage Tuesday, often talking over one another as they faced off in the final Democratic debate before the South Carolina primary and Super Tuesday. NPR’s Domenico Montanaro and Danielle Kurtzleben take a look at some of the top moments. •

Read “4 Takeaways From The South Carolina Democratic Debate” 

Exhibitions: Inside Look At “Picasso And Paper”, Royal Academy Of Arts (Video)

Join Curator Ann Dumas for a view inside the ‘Picasso and Paper’ exhibition, which features works spanning the artist’s entire career. Can you guess which work the artist made when he was just nine years old?

Website