Category Archives: Health

Health Talk: “Colorectal Cancer” & Importance Of Screening (Mayo Clinic)

 

On the Mayo Clinic Radio program, Dr. John Kisiel, a Mayo Clinic gastroenterologist, discusses colorectal cancer and the importance of recommended screening tests.

This interview originally aired March 7, 2020. Disclaimer: Mayo Clinic has a financial interest in Exact Sciences.

Among cancers that affect men and women, colorectal cancer is the second leading cause of cancer deaths in the U.S., according to the Centers for Disease Control and Prevention. Most cases of colorectal cancer begin as small, noncancerous (benign) clumps of cells called polyps. Over time, some polyps become colon cancer. Because these polyps may be small and produce few, if any, symptoms, health care providers recommend regular screening tests to prevent colon cancer. These screenings identify and remove polyps before they become cancerous. March is Colorectal Cancer Awareness month, a time to educate the public about the importance of colorectal cancer screening.

Studies: Elderly In 3rd Highest Level Of Exercise Reduce Brain Shrinkage, Aging By 4 Years (AAN)

From a March 5, 2020 American Academy of Neurology release:

American Academy of Neurology (AAN) Logo“These results are exciting, as they suggest that people may potentially prevent brain shrinking and the effects of aging on the brain simply by becoming more active,” said study author Yian Gu, Ph.D., of Columbia University in New York and a member of the American Academy of Neurology.

“Recent studies have shown that as people age, physical activity may reduce the risk of cognitive decline and dementia. Our study used brain scans to measure the brain volumes of a diverse group of people and found that those who engaged in the top third highest level of physical activity had a brain volume the equivalent of four years younger in brain aging than people who were at the bottom third activity level.”

Older people who regularly walk, garden, swim or dance may have bigger brains than their inactive peers, according to a preliminary study to be presented at the American Academy of Neurology’s 72nd Annual Meeting in Toronto, Canada, April 25 to May 1, 2020. The effect of exercise was equal to four fewer years of brain aging. The study used magnetic resonance imaging (MRI) scans to measure the brains of people with a range of activity levels, including those who were inactive to those who were very active. The scans showed less active people had smaller brain volume.

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Health Studies: “Habitual” Supplementation Of Fish Oil (Omega-3) Lowers “All Cause Mortality” (BMJ)

From a BMJ Research study (March 4, 2020):

The BMJ podcastHabitual fish oil supplementation is associated with a 13% lower risk of all cause mortality, a 16% lower risk of CVD mortality, and a 7% lower risk of CVD events among the general population

Fish oil is a rich source of long chain omega 3 fatty acids, a group of polyunsaturated fats that primarily include eicosapentaenoic acid and docosahexaenoic acid. Initially, these compounds were recommended for daily omega 3 fatty acid supplementation for the prevention of cardiovascular disease (CVD). Consequently, the use of fish oil supplements is widespread in the United Kingdom and other developed countries.

Omega-3 Fatty Acids Cardiovascular Protection

Several mechanisms could explain the benefits for clinical outcome derived from fish oil supplementation. Firstly, the results of several studies have indicated that supplementation with omega 3 fatty acids has beneficial effects on blood pressure, plasma triglycerides, and heart rate, all of which would exert a protective effect against the development of CVD. Secondly, several trials have shown that omega 3 fatty acids can improve flow mediated arterial dilatation, which is a measure of endothelial function and health. Thirdly, omega 3 fatty acids have been shown to possess antiarrhythmic properties that could be clinically beneficial. Finally, studies have reported that fish oil can reduce thrombosis. Additionally, studies have reported that the anti-inflammatory properties of fish oil could have a preventive role in the pathophysiology of CVD outcomes. Other mechanisms could also be involved to explain the effect of fish oil on CVD outcomes.

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Heart Health Video: “Beta Blockers” Lower CVD Risks Of Harmful Gut Microbes

Hazen and colleagues find that gut bacteria play a central role in the conversion of dietary proteins into a compound, phenylacetylglutamine ( PAGln), which not only is associated with future cardiovascular disease risk in humans but also promotes platelet responsiveness and blood clotting potentially via adrenergic receptors, according to mouse models.

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Interview: Scientist And Inventor Mark Kendall – “Nanopatch” Replacement For Vaccination (Podcast)

Monocle 24 Pioneers logoRocket scientist-turned-immunology expert Mark Kendall talks about his Nanopatch, which could revolutionise vaccinations and eradicate some diseases.

Mark Kendall (born 1972) is an Australian biomedical engineer and innovator. He is an Entrepreneurial Professor of the Australian National University. His field of research is the delivery of immunotherapeutics to the skin without the use of a needle or syringe.

In 2011, he co-founded the development company Vaxxas with an investor syndicate. The company’s technology, called Nanopatch, is intended to serve as a needle-free vaccine delivery device. In 2011, Kendall and his AIBN team received the Australian Research Council Eureka Prize for Excellence in Research by an Interdisciplinary Team. In 2012, he was awarded the Rolex Awards for Enterprise for his “pioneering efforts to expand knowledge and improve human life”.

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Study: Sunlight Exposure Lowers Blood Pressure, Avoiding It Is Risk Factor For Hypertension (AHA)

From an American Heart Assoc. Journal study (Feb 28, 2020):

American Heart Association LogoSeasonal variation in blood pressure has been known for 40 years, but, to our knowledge, for the first time we show here that this occurs independently of temperature. The reduction in blood pressure is more marked with a rise in UVB than UVA, and in whites than black people. Dermatological concerns about the skin cancer inducing effects of UV radiation need to be balanced against the observed blood pressure lowering effects of sunlight, particularly given the greatly higher burden of disease caused by hypertension.

Incident Solar Ultraviolet Exposure lowers Blood Pressure AHA Feb 28 2020Sunlight exposure appears to lower blood pressure; insufficient exposure to natural ultraviolet radiation and/or active avoidance of sunlight may be new risk factors for hypertension.

Hypertension remains a leading global cause for premature death and disease. Most treatment guidelines emphasize the importance of risk factors, but not all are known, modifiable, or easily avoided. Population blood pressure correlates with latitude and is lower in summer than winter. Seasonal variations in sunlight exposure account for these differences, with temperature believed to be the main contributor. Recent research indicates that UV light enhances nitric oxide availability by mobilizing storage forms in the skin, suggesting incident solar UV radiation may lower blood pressure. We tested this hypothesis by exploring the association between environmental UV exposure and systolic blood pressure (SBP) in a large cohort of chronic hemodialysis patients in whom SBP is determined regularly.

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Diet Study: “Moderate Egg Consumption” Does Not Increase Cardiovascular Disease Risk (The BMJ)

From a BMJ Research online study (March 4, 2020):

BMJ Open Access logoWe found no association between egg consumption and risk of cardiovascular disease in three large US cohorts. Results from the updated meta-analysis lend further support to the overall lack of an association between moderate egg consumption (up to one egg per day) and cardiovascular disease risk. 

One Large Egg Nutrition factsEggs are a major source of dietary cholesterol, but they are also an affordable source of high quality protein, iron, unsaturated fatty acids, phospholipids, and carotenoids.

Introduction: In the United States, cardiovascular disease is the leading cause of death in men and women. Diet and lifestyle undisputedly play a major part in the development of cardiovascular disease. In the past, limiting dietary cholesterol intake to 300 mg per day was widely recommended to prevent cardiovascular disease. However, because of the weak association between dietary cholesterol and blood cholesterol, and considering that dietary cholesterol is no longer a nutrient of concern for overconsumption, the most recent 2015 dietary guidelines for Americans did not carry forward this recommendation.

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Coronavirus / Covid -19: “What Happens When It Enters Your Body” (Video)

The Telegraph LogoWhat happens when you catch coronavirus? The Telegraph’s Global Health Security Editor Paul Nuki explains all the ways in which you could become infected with COVID-19 and how your body reacts to this virus.

What happens when the virus enters the body?

When the virus enters your body it binds to two cells in the lungs – goblet cells that produce mucus and cilia cells which have hairs on them and normally prevent your lungs filling up with debris and fluid such as virus and bacteria and particles of dust and pollen.

The virus attacks these cells and starts to kill them – so your lungs begin to fill with fluid making it hard for you to breathe. This phase of the disease is thought to last about a week.

At this point your immune system will start to kick in and fight off the invaders. You will develop a fever and your high body temperature will create a hostile environment for the virus. You will start to get rid of the mucus in the form of coughing and a runny nose.

But in some people – particularly the elderly and those with other health conditions – the immune system can go into overdrive. As well as killing the virus it also starts to kill healthy cells.

This heightened immune response can trigger a “cytokine storm” – white blood cells activate a variety of chemicals that can leak into the lungs, which along with the attack on the cells damages them even further. Scans of the lungs show “ground-glass” opacity and then “crazy paving” patterns, as they fill with mucus making it harder and harder to breathe.

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Health: All Adults 18-79 Should Be Screened For Hepatitis C Virus (HCV)

From a Stanford University online article (March 2, 2020):

Health Policy Stanford“The opioid epidemic has added fuel to the HCV fire, substantially increasing transmission,” said Owens. “HCV is now an enormous public health problem, affecting a much broader age range of people than before. Fortunately, we have the tools to identify people and treatment is now successful in the vast majority of patients, so screening can prevent the mortality and morbidity from HCV.”

A task force of national health experts recommends clinicians screen all adults 18 to 79 for the hepatitis C virus (HCV), noting that the viral infection is now associated with more deaths in the United States than the top 60 reportable infectious diseases combined. Many people are unaware they are carrying the viral infection.

CDC-viral-hepatitis-work-P-page-0

“People with hepatitis C do not always feel sick and may not know they have it,” says chair of the U.S. Preventive Services Task Force Douglas K. Owens, M.D, M.S. “Screening is key to finding this infection early, when it’s easier to treat and cure, helping reduce illnesses and deaths.”

Owens, who is the director of Stanford Health Policy and the Henry J. Kaiser, Jr., Professor of Medicine, said the opioid epidemic now plays an important role in the prevalence of HCV. There are more than three times the number of acute HCV cases than a decade ago, particularly among young, white, injection drug users who live in rural areas. Women aged 15 to 44 have also been hit hard by the virus that is spread through contaminated blood.

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