One year. Ten stories.
As 2022 enters its final weeks, we look back on the past 12 months through the lens of Nature’s 10 — ten people who helped to shape science during the year. The cover takes its inspiration from the stunning images that have so far emerged from the James Webb Space Telescope. Launched on Christmas Day 2021, the telescope sent its first image back to Earth this summer and has since provided astronomers with views of the Universe in unprecedented detail.
Why does fat return after dieting? The microbiome might have a hand
Experiments on mice suggest that gut bacteria contribute to the post-diet rebound of fat tissue.
Blue diamonds from the deep Earth are all wet
Chemical analysis of rare gems suggests that seawater played a part in their creation.
These daily oscillations are controlled by the circadian clock, which is composed of an autoregulatory biochemical mechanism that is expressed in tissues throughout the body and is coordinated by a master pacemaker located in the suprachiasmatic nuclei of the brain (aka the SCN [
to a paper Mattson and colleagues published in February in the experimental biology journal FASEB. In humans, fasting for 12 hours or more drops the levels of glycogen, a form of cellular glucose. Like changing to a backup gas tank, the body switches from glucose to fatty acids, a more efficient fuel. The switch generates the production of ketones, which are energy molecules that are made in the liver. “When the fats are mobilized and used to produce ketones, we think that is a key factor in accruing the health benefits,” says Mattson.
This latest paper builds on previous Newcastle studies supported by 
In summary, dietary fructose, but not glucose, supplementation of HFD impairs mitochondrial size, function, and protein acetylation, resulting in decreased fatty acid oxidation and development of metabolic dysregulation.
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