Category Archives: Studies

Dementia: Antioxidant “Flavonols” From Fruits & Vegetables Lower Alzheimer’s Risk By 48%

January 31, 2020 She Seeks Serene Leave a comment

From a Rush University Medical Center online article:

The study found that participants in the group with the highest flavonol consumption were 48% less likely to develop Alzheimer’s dementia later on in life than participants with the lowest level. Of the 186 people in the highest group, 28 people, or 15%, developed Alzheimer’s dementia, compared to 54 people, or 30%, of the 182 people in the lowest group.

People who eat or drink more foods with flavonol, which is found in nearly all fruits and vegetables, plus tea and wine, may be less likely to develop Alzheimer’s dementia, according to the Rush researchers. They published the results of their study in the Jan. 29 online issue of Neurology.

Flavonols are a type of flavonoid, a group of phytochemicals found in plant pigments. They are known for their beneficial effects on health due to their antioxidant and anti-inflammatory properties.

A total of 921 people with an average age of 81 participated in the Neurology study. These participants did not have Alzheimer’s dementia when starting the study.

Health, News, Sleep, Studies

Studies: Irregular Sleep Disrupts Pancreatic “Circadian Rhythms”, Leading To Type 2 Diabetes

January 31, 2020 She Seeks Serene Leave a comment

From a Technology Networks online article:

By comparing the pancreatic cells of type 2 diabetic human donors with those of healthy people, researchers at the University of Geneva (UNIGE) and at the University Hospitals of Geneva (HUG), Switzerland, were able to demonstrate, for the first time, that the pancreatic islet cells derived from the Type 2 Diabetic human donors bear compromised circadian oscillators.

The disruption of the circadian clocks was concomitant with the perturbation of hormone secretion. Moreover, using clock modulator molecule dubbed Nobiletin, extracted from lemon peel, the researchers succeeded in “repairing” the disrupted cellular clocks and in partial restoring of the islet cell function. These results, published in the Proceedings of the National Academy of Sciences of the United States, provide a first insight into innovative approach for diabetes care.

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The circadian clock system (from Latin “circa diem”, about a day) allows the organisms to anticipate periodical changes of geophysical time, and to adjust to these changes. Nearly all the cells in our body comprise molecular clocks that regulate and synchronize metabolic functions to a 24-hour cycle of day-night changes.

Today, increasing evidence show that disturbances in our internal clocks stemming from frequent time zone changes, irregular working schedules or ageing, have a significant impact on the development of metabolic diseases in human beings, including type-2 diabetes. Such disturbances seem to prevent the proper functioning of the cells in the pancreatic islet that secrete insulin and glucagon, the hormones that regulate blood sugar levels.

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Diet & Nutrition, Food, Health, Studies

Nutrition Studies: 70% Of U.S. Fast-Food Meals Are “Poor Dietary Quality”

January 30, 2020 She Seeks Serene Leave a comment

“Our findings show dining out is a recipe for unhealthy eating most of the time,” said Dariush Mozaffarian, senior author and dean of the Friedman School.

At fast-food restaurants, 70 percent of the meals Americans consumed were of poor dietary quality in 2015-16, down from 75 percent in 2003-04. At full-service restaurants, about 50 percent were of poor nutritional quality, an amount that remained stable over the study period. The remainder were of intermediate nutritional quality.

BOSTON (Jan. 29, 2020, 9:00 a.m. EST)—The typical American adult gets one of every five calories from a restaurant, but eating out is a recipe for meals of poor nutritional quality in most cases, according to a new study by researchers at the Friedman School of Nutrition Science and Policy at Tufts University.

Published today in The Journal of Nutrition, the study analyzed the dietary selections of more than 35,000 U.S. adults from 2003-2016 in the National Health and Nutrition Examination Survey (NHANES) who dined at full-service (those with wait staff) or fast-food restaurants, which included pizza shops and what has become known as fast-casual. The researchers assessed nutritional quality by evaluating specific foods and nutrients in the meals, based on the American Heart Association 2020 diet score.

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Exercise, Fitness, Health, Studies

Exercise: Older Adults With Higher Muscle Mass Reduce Cardiovascular Disease By Over 80% (Study)

January 29, 2020 She Seeks Serene Leave a comment

From a Journal of Epidemiology & Community Health online release:

The 10 year CVD (cardiovascular disease) incidence increased significantly across the baseline SMI (skeletal muscle mass index) tertiles (p<0.001). Baseline SMM (Skeletal muscle mass) showed a significant inverse association with the 10 year CVD incidence (HR 0.06, 95% CI 0.005 to 0.78), even after adjusting for various confounders. Additionally, participants in the highest SMM tertile had 81% (95% CI 0.04 to 0.85) lower risk for a CVD event as compared with those in the lowest SMM tertile.

Background Skeletal muscle mass (SMM) is inversely associated with cardiometabolic health and the ageing process. The aim of the present work was to evaluate the relation between SMM and 10 year cardiovascular disease (CVD) incidence, among CVD-free adults 45+ years old.

Methods ATTICA is a prospective, population-based study that recruited 3042 adults without pre-existing CVD from the Greek general population (Caucasians; age ≥18 years; 1514 men). The 10 year study follow-up (2011–2012) captured the fatal/non-fatal CVD incidence in 2020 participants (50% men). The working sample consisted of 1019 participants, 45+ years old (men: n=534; women: n=485). A skeletal muscle mass index (SMI) was created to reflect SMM, using appendicular skeletal muscle mass (ASM) standardised by body mass index (BMI). ASM and SMI were calculated with specific indirect population formulas.

The global population is ageing at an unprecedented speed, especially in Europe. As a concept, ageing is considered a continuous process starting from birth and is accompanied by various physiological changes and a number of comorbidities1 2 that affect health and quality of life.3 4 Skeletal muscle mass (SMM)4 alterations are among these physiological changes.

SMM tissue decline, as a part of these physiological changes, starts in middle age (or even earlier, in the 30s) and progresses in more advanced age.5 It has been shown that SMM declines with a rate of more than 3% per decade starting from the age of 30+.6 Half of the human body’s mass is actually SMM and it has an active role in numerous metabolic pathways.5 7 SMM decline is related, among others, to various disability patterns, poor mental health and increased mortality.5 7 8 In addition, well documented studies have shown that SMM alterations are related to cardiovascular health,9 10 even different muscle morphology.11 Recently, Srikanthan et al 12 reported the importance of muscle tissue in relation to cardiovascular disease (CVD) and total mortality in stable CVD patients.

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Diet, Medicine, Podcasts, Studies

Weight Loss: Medical Review Of “Keto, Atkins, and Pritikin Diets” (JAMA)

Audio January 29, 2020 She Seeks Serene Leave a comment

There are many named diets that receive a great deal of attention. But what are they and do they work? David Heber, MD, PhD, from the UCLA Center for Human Nutrition explains these diets.

Health, Medicine, Studies

Studies: Heart Surgery Patients Can Be Safely Discharged In 3 Days

January 29, 2020 She Seeks Serene Leave a comment

From a News-Medical.net online release:

“Patients can go home after a shorter length of stay in the hospital without increased risk of complications and rehospitalizations,” said Dr. Malaisrie. “Because we found no detrimental effect of accelerated discharge, both patients and physicians should not be averse to discharging patients when medically ready.”

Dr. Malaisrie anticipates that the Northwestern Medicine cardiac ERAS program will result in faster recoveries, reduced complications, decreased time in the hospital, lower costs, and improved patient/family satisfaction. In the future, the researchers plan to closely examine both traditional clinical endpoints and patient-reported outcomes from the program.

“Expectations for recovery after cardiac surgery are being reset in the current era,” he said. “What does this mean for patients? It means that prolonged or taxing recovery is no longer required. Patients should know that recovery from heart surgery is not only quicker, but also better with ERAS programs.”

Aging, Health, News, Studies

Studies: Depression Diagnosis Increases Risk Of Dementia For Decades

January 24, 2020 She Seeks Serene Leave a comment

From a PLOS Medicine online study:

Depression is associated with increased odds of dementia, even more than 20 years after diagnosis of depression, and the association remains after adjustment for familial factors. Further research is needed to investigate whether successful prevention and treatment of depression decrease the risk of dementia.

The risk of dementia is increased for decades after a diagnosis of depression, where those diagnosed with especially severe depressions are at increased risk.

Dementia is common among the elderly, causing severe individual suffering as well as societal strain. As the proportion of people aged 65 years and above is rapidly increasing in the world population, the number of individuals with dementia is expected to double within 20 years, and this condition was estimated to have a worldwide cost of US$604 billion in 2010. Effective treatments for dementia remain scarce; however, a preventive approach may be possible through the identification of high-risk individuals and potentially modifiable risk factors.

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Health, Medicine, News, Science, Studies

Research: Scientists Find Protein To Regulate Immune Attacks, Reduce Rheumatoid Arthritis

January 21, 2020 She Seeks Serene Leave a comment

From a New Atlas online article:

Scientists have just discovered a new mechanism that can be key in regulating these immune attacks, raising new hopes of drugs that can protect against joint inflammation and the ailments it can bring.

Through the use of the CRISPR gene-editing tool, the Karolinska Institutet scientists have now shed further light on the role they play in inflammation. The technology enabled the team to make adjustments to a set of hand-picked immune cell genes as a way of learning how those tweaks can impact the behavior of the cells.

“The results we obtained using CRISPR were key to quickly understanding how the system under study is regulated,” says Dr Wermeling. “I have high hopes that the experimental use of CRISPR will be hugely important to our understanding of how immune-cell behavior is regulated, and that this can guide us in the development of new efficacious drugs.”

https://newatlas.com/medical/newly-understood-protein-raises-hopes-of-advanced-arthritis-treatments/?utm_source=New+Atlas+Subscribers&utm_campaign=68b0bd3225-EMAIL_CAMPAIGN_2020_01_21_02_40&utm_medium=email&utm_term=0_65b67362bd-68b0bd3225-93002753

Health, News, Studies

Health Studies: Marijuana Use Associated With Rise In Cardiovascular Disease

January 21, 2020 She Seeks Serene Leave a comment

From a Journal of the American College of Cardiology:

Observational data suggest associations between marijuana and a broad range of adverse cardiovascular risks. Marijuana is becoming increasingly potent, and smoking marijuana carries many of the same cardiovascular health hazards as smoking tobacco. Synthetic cannabinoids have been linked to more sustained and deleterious pharmacodynamic effects.

Marijuana use is increasing as more states are legalizing cannabis for both medicinal and recreational purposes. National survey data estimate that >2 million Americans with established cardiovascular diseases currently use or have used marijuana in its variety of forms, including inhalation and vaping. Cannabinoid receptors are distributed in multiple tissue beds and cells, including platelets, adipose tissue, and myocytes.

Highlights

• We estimate that >2 million U.S. adults who have reported ever using marijuana have cardiovascular disease.
• Observational studies have suggested an association between marijuana use and a range of cardiovascular risks.
• Marijuana is becoming increasingly potent, and smoking marijuana carries many of the same cardiovascular health hazards as smoking tobacco.
• Few randomized clinical trials have been conducted or are planned to explore the effects of marijuana on cardiovascular risk.
• Screening and testing for use of marijuana are encouraged in clinical settings, especially in the care of young patients presenting with cardiovascular disease.

Health, News, Studies

Studies: Openly Given “Placebos” Are Effective For Chronic Pain Relief

January 20, 2020 She Seeks Serene Leave a comment

From a Wall Street Journal online article:

Researchers in Germany published a study in the journal Pain in December showing that open-label placebos can help relieve chronic lower-back pain, replicating a 2016 study. A similar study by University of Colorado, Boulder researchers found that placebo saline injections reduce chronic lower-back pain.

Two other recent studies showed placebos openly given to cancer patients helped relieve cancer-related fatigue. And a forthcoming study by German researchers found openly giving placebo to elderly patients helped improve knee pain.

More researchers are looking at the idea of placebos—substances that have no actual pharmaceutical effect—as an alternative to traditional pain medications, which can be ineffective and carry significant side effects. Placebos might have particular potential for difficult-to-treat conditions like chronic back pain, cancer-related fatigue and symptoms of irritable bowel syndrome, researchers hope.

As many as 30% to 50% of chronic pain patients will respond to placebos, research suggests. And new studies are helping to identify genetic and brain differences that make certain people more likely to respond.