Featuring articles on lung-cancer screening in the NELSON trial, ribociclib and fulvestrant in metastatic breast cancer, vitamin D in pregnancy and asthma, treatment thresholds for neonatal hypoglycemia, and CAR-NK cells in anti-CD19 lymphoid tumors; a review article on placebo and nocebo effects; a Clinical Problem-Solving describing a rapid change in pressure; and Perspective articles on altruism in Extremis, on abuses of FDA regulatory procedures, and on joining forces against delirium.
Hear the latest from the world of science, brought to you by Benjamin Thompson and Nick Howe. This week, how setting an out-of-office email could help promote a kinder academic culture.
In this episode:
Last year, a viral tweet about emails sparked a deeper conversation about academics’ work-life-balance. Could email etiquette help tip the balance? Careers Article: Out of office replies and what they can say about you
Finding the ‘greenest’ oranges, and the benefits of ‘baby talk’. Research Article: Bell and Horvath; Research Highlight: Babies benefit when Mum and Dad are fluent in ‘baby talk’
Updates on the novel coronavirus, assessing Iran’s nuclear capabilities, and the potential impacts of Brexit on UK research. News: Coronavirus: latest news on spreading infection; News: How quickly can Iran make a nuclear bomb?; News: Brexit is happening: what does it mean for science?
March 7 – June 21, 2020
This major exhibition charts the career of the artist known simply as El Greco. Over 57 works from across the world trace not only the development of his distinctive style but also the astounding ambition that drove him to relentlessly pursue success.
Born in Crete as Domenikos Theotokopoulos (1541–1614), El Greco trained in the traditional manner of Byzantine icon painting. He moved to Venice in 1567 to learn a new artistic approach, absorbing developments in Venetian Renaissance painting through the lens of artists such as Titian and Tintoretto. The works El Greco painted during his time in Venice, however, reveal both his embrace of and struggles to fully adapt to this manner of painting.
Following this transformative period, El Greco went to Rome, probably in an attempt to attract patronage within the papal circle. There his acceptance into the elevated circle of Cardinal Alessandro Farnese brought a close association with the painter Giulio Clovio and the erudite historian and collector Fulvio Orsini. El Greco’s portraits, allegories, and religious paintings between 1570 and 1577 reflect these relationships as well as his complicated engagement with Michelangelo and other artistic luminaries of the 16th century.
Amy Walter of the Cook Political Report and Radio Iowa’s O. Kay Henderson join John Yang in Iowa to discuss the latest political news, including what voters in Iowa’s first-in-the-nation 2020 Democratic caucuses are considering as they make their selections, polling updates on a “fluid” and “volatile” race and the ongoing pace of campaigning in Iowa.From a JAMA Network Open online release (Jan 31, 2020):
Steep incidence increases between 49 and 50 years of age are consistent with previously undetected colorectal cancers diagnosed via screening uptake at 50 years. These cancers are not reflected in observed rates of colorectal cancer in the SEER registries among individuals younger than 50 years. Hence, using observed incidence rates from 45 to 49 years of age alone to assess potential outcomes of earlier screening may underestimate cancer prevention benefits.
Early-onset colorectal cancer (EOCRC) incidence rates are increasing, and controversy exists regarding whether average-risk screening should begin at 45 or 50 years of age.1 In 2018, the American Cancer Society recommended that average-risk screening start at 45 years of age.2 Others recommend screening at 50 years of age, although the US Multi-Society Task Force on Colorectal Cancer recommends screening African American individuals at age 45 years of age owing to higher incidence, mortality, and earlier-onset disease.3–6 The American Cancer Society decision incorporated modeling studies that used updated incidence and mortality data encompassing time periods of increasing EOCRC incidence rates; modeling compared life-years gained by initiating screening at 45 vs 50 years.
From Carolyn K. Reidy, President & CEO of Simon & Schuster:
“She was unique. Nobody ever bonded more completely with her readers than Mary did; she understood them as if they were members of her own family. She was always absolutely sure of what they wanted to read—and, perhaps more important, what they didn’t want to read—and yet she managed to surprise them with every book. She was the Queen of Suspense, it wasn’t just a phrase; she always set out to end each chapter on a note of suspense, so you just had to keep reading. It was at once a gift, but also the result of hard work, because nobody worked harder than Mary did on her books to deliver for her readers. She was also, unfailingly, cheerful under pressure, generous, good humored and warm-hearted, the least ‘temperamental’ of bestselling authors, and the most fun to be around.
It is with great sadness that I write to inform you that Mary Higgins Clark died January 31, 2020 in Naples, Florida, at the age of 92. The cause was complications of old age.
It is impossible to overestimate the importance of Mary’s contribution to our success, and her role in the modern history of Simon & Schuster. Beginning in 1975 with the publication of WHERE ARE THE CHILDREN, each of her 56 books has been a bestseller. There are more than 100 million copies of her books in print in the United States; they are international bestsellers and have been translated into every major and many less well-known languages.
The winter break is finally over and the automotive year is about to kick off in emphatic fashion at Rétromobile, undeniably the finest event of its type on the planet.
The annual salon is Paris provides manufacturers with a stage on which to show off their commitment to preserving their precious pasts, dealers the chance to set out their stalls and signal their intentions for the coming year and humble enthusiasts like us an opportunity to ogle thousands of collectable cars ranging from the affordable and the obscure to the rare and the downright priceless.
New York Times columnist David Brooks and Washington Post columnist Ruth Marcus join Judy Woodruff to discuss the week’s political news, including the Senate’s decision not to call witnesses in President Trump’s impeachment trial, Republicans’ varying defenses of Trump’s conduct around Ukraine and what recent polling trends among 2020 Democrats suggest about Monday’s Iowa caucuses.
Boomers Daily 