An estimated 80 million people live with a neurodegenerative disease, with this number expected to double by 2050. Despite decades of research and billions in funding, there are no medications that can slow, much less stop, the progress of these diseases. The time to rethink degenerative brain disorders has come. With no biological boundaries between neurodegenerative diseases, illnesses such as Parkinson’s and Alzheimer’s result from a large spectrum of biological abnormalities, hampering effective treatment.
Acclaimed neurologist Dr Alberto Espay and Parkinson’s advocate Benjamin Stecher present compelling evidence that these diseases should be targeted according to genetic and molecular signatures rather than clinical diagnoses. There is no Parkinson’s or Alzheimer’s, simply people with Parkinson’s or Alzheimer’s. An incredibly important story never before told, Brain Fables is a wakeup call to the scientific community and society, explaining why we have no effective disease-modifying treatments, and how we can get back on track.
Contributing Correspondent Lizzie Wade talks with host Sarah Crespi about the role of inequality in past pandemics. Evidence from medical records and cemeteries suggests diseases like the 1918 flu, smallpox, and even the Black Death weren’t indiscriminately killing people—instead these infections caused more deaths in those with less money or status. 
Five generations after Giovanni Gaja founded his eponymous winery in the Piedmont town of Barbaresco, the family continues to produce some of Italy’s best vintages. Their uncompromising commitment to quality is helping to maintain one of the world’s finest vintners.
This week, Elisabeth Bik tells us about her work uncovering potential image manipulation, and a new route for particulate pollution formation.
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