Use of polypill was effective in preventing major cardiovascular events. Medication adherence was high and adverse event numbers were low. The polypill strategy could be considered as an additional effective component in controlling cardiovascular diseases, especially in LMICs.
When restricted to participants in the polypill group with high adherence, the reduction in the risk of major cardiovascular events was even greater compared with the minimal care group…
A fixed-dose combination therapy (polypill strategy) has been proposed as an approach to reduce the burden of cardiovascular disease, especially in low-income and middle-income countries (LMICs). The PolyIran study aimed to assess the effectiveness and safety of a four-component polypill including aspirin, atorvastatin, hydrochlorothiazide, and either enalapril or valsartan for primary and secondary prevention of cardiovascular disease.
From a Wall Street Journal article by Katherine Clark:
“If you look back in the day to the ’70s and ’80s, there were these guys…raised with this mythology of the West,” said Ken Mirr, a local ranch broker. “It was attachment to something Hollywood produced. Their children aren’t necessarily always as interested in operating the properties. Sometimes the kids just see cows and think ‘What should I do with this?’”
Operating costs vary dramatically, depending on how much infrastructure ranchers have on their land and the level of agricultural activity but can often be millions a year.
Decades ago, a generation of America’s wealthiest, raised on television shows like “Howdy Doody” and “The Lone Ranger,” headed west with dreams of owning some of the country’s most prestigious ranches. Now, as those John Wayne- loving baby boomers age out of the lifestyle or die, they or their children are looking to sell those trophy properties.
The use of n-3 FA (4 g/d) for improving atherosclerotic cardiovascular disease risk in patients with hypertriglyceridemia is supported by a 25% reduction in major adverse cardiovascular events in REDUCE-IT (Reduction of Cardiovascular Events With EPA Intervention Trial), a randomized placebo-controlled trial of EPA-only in high-risk patients treated with a statin.
The results of a trial of 4 g/d prescription EPA+DHA in hypertriglyceridemia are anticipated in 2020. We conclude that prescription n-3 FAs (EPA+DHA or EPA-only) at a dose of 4 g/d (>3 g/d total EPA+DHA) are an effective and safe option for reducing triglycerides as monotherapy or as an adjunct to other lipid-lowering agents.
Hypertriglyceridemia (triglycerides 200–499 mg/dL) is relatively common in the United States, whereas more severe triglyceride elevations (very high triglycerides, ≥500 mg/dL) are far less frequently observed. Both are becoming increasingly prevalent in the United States and elsewhere, likely driven in large part by growing rates of obesity and diabetes mellitus.
Syndicated columnist Mark Shields and Ramesh Ponnuru of The National Review join Judy Woodruff to discuss the latest political news, including President Trump’s trade war with China and attacks on the Fed and how they’re affecting the U.S. economy, three recent Democratic departures from the 2020 presidential race and the legacy of billionaire GOP donor David Koch.
People call it the “crown jewel” of the Oregon State Parks system, and once you visit, you know why. Silver Falls State Park is the kind of standout scenic treasure that puts Oregon firmly onto the national—and international—stage. Its beauty, boundless recreational opportunities and historic presence keep it there.
Waterfalls: Where else can you walk behind a waterfall? Check out the famous South Falls and see what a 177-foot curtain of water looks like from behind. It’s part of the Trail of Ten Falls, a spectacular, nationally recognized hiking trail that weaves through a dense forested landscape. The trail passes a series of breathtaking waterfalls along a rocky canyon, and descends to a winding creek at the forest floor. This 7.2 mile loop is considered to be a moderate hike, with an overall elevation change of 800 feet. Several connecting trails with separate access points make shorter routes. For everyone’s safety— absolutely no pets allowed on the Canyon Trail. Pets on leash are allowed on all other trails.
Boots, bikes, paws, hooves: The park offers more than 35 miles of backcountry trails for mountain biking, hiking or horseback riding (see guided ride info below). Bears and cougars live in the more remote park areas.
In Montparnasse begins on the eve of the First World War and ends with the 1936 unveiling of Dalí’s Lobster Telephone. As those extraordinary years unfolded, the Surrealists found ever more innovative ways of exploring the interior life, and asking new questions about how to define art. In Montparnasse recounts how this artistic revolution came to be amidst the salons and cafés of that vibrant neighborhood.
Sue Roe is both an incisive art critic of these pieces and a beguiling biographer with a fingertip feel for this compelling world. Beginning with Duchamp, Roe then takes us through the rise of the Dada movement, the birth of Surrealist photography with Man Ray, the creation of key works by Ernst, Cocteau, and others, through the arrival of Dalí. On canvas and in their readymades and other works these artists juxtaposed objects never before seen together to make the viewer marvel at the ordinary—and at the workings of the subconscious. We see both how this art came to be and how the artists of Montparnasse lived.