For many older adults, a good night’s rest is elusive. The implications of chronically poor sleep can be far-reaching and include a decline in cognitive functioning and detrimental effects on health and general well-being. Fortunately, relief may be in sight.
A new study led by investigators at the Stanford University School of Medicine shows that neurons in the lateral hypothalamus, a brain region, play a pivotal role in sleep loss in old mice. More specifically, the arousal-promoting hypocretin neurons become hyperexcitable, driving sleep interruptions.
Luis de Lecea, PhD, is a professor of psychiatry and behavioral sciences at Stanford Medicine. He is the study’s senior author and hopes the finding could pave the way to new drug treatments for age-related sleep problems in humans.
Shi-Bin Li, PhD, is an instructor in the Psychiatry and Behavioral Sciences department at Stanford Medicine. He is also a basic life research scientist in the de Lecea lab, and is the lead author of the study.
Rose Park House is a luxury house designed to create a journey of discovery. Carefully crafted by studio gram, the robust residence represents a legacy project for the clients; a home to last a lifetime and house generations to come.
Video timeline: 00:00 – The Local Project Print Publication 00:16 – Introduction to Rose Park House 00:40 – A Legacy Project 01:06 – The History of The Queen Anne Villa 01:29 – Materials and Architecture That Leave a Legacy 02:26 – A Wine Room for the Ages 03:02 – Key Components of The Extension 03:40 – Practical and Fully Accessible 04:14 – Longevity & Long Lasting Relationships 04:53
Sitting at the fringe of the Adelaide Park Lands, Rose Park House is the final architectural project to be initiated by the clients. The design brief for the luxury house entailed a structure that could stand the test of time and was a reimagination of the existing residence which was originally built in the 1900s.
Studio gram selects durable materials for Rose Park House. Dark-toned limestone and American walnut speak to a sense of longevity and visually contrast the bright natural light that fills the internal spaces. An investigation of the pre-existing home revealed architecture comprised of off-form concrete. The modern extension of the luxury house continues the materiality of the original dwelling.
Rose Park House is also designed with a focus on accessibility. Accessible ramps, flush thresholds and wide apertures are featured in consideration of occupants who use wheelchairs. Smoothly integrated into the overall scheme, the features demonstrate that in a luxury house, form and function are not necessarily conceived as competing interests.
As a luxury house, Rose Park House is imbued with a feeling that is almost ineffable; a feeling of permeating goodness and rightful being. Achieving longevity and timelessness, studio gram crafts a luxury house with a growing legacy.
Salvador, the capital of Brazil’s northeastern state of Bahia, is known for its Portuguese colonial architecture, Afro-Brazilian culture and a tropical coastline. The Pelourinho neighborhood is its historic heart, with cobblestone alleys opening onto large squares, colorful buildings and baroque churches such as São Francisco, featuring gilt woodwork.
Located in the northwestern part of Belgium and is the main beach of the resort town of Blankenberg. This is one of the most fun and lively beaches in Belgium, where every visitor will find something to his liking. You can get to it by car, bus or beach tram, which runs along the entire coast.
Picasso & Braque: Radicals highlights significant work by the two pioneers of the Cubist art movement—Pablo Picasso and Georges Braque. Cubism, one of the most influential artistic developments of the twentieth century, challenged traditional perspectives of how we see the world. The movement is characterized by fractured viewpoints and abstracted forms and defies established notions of three-dimensionality. Cubism can be intellectually challenging but beautifully reflects the dynamism, rhythm, and innovation of the early 1900s.
Although there is debate on who developed Cubism first, Picasso and Braque are credited with establishing this new visual language that presented infinite possibilities and catalyzed future developments in the visual arts. This exhibition features work by twentieth-century artists who took inspiration from these revolutionary ideas and practices, including American artists Fannie Hillsmith and John Marin, and Texas artist Bill Reily, among others. Paintings, drawings, sculptures, and prints demonstrate how Cubism transcended time and space.
Picasso & Braque: Radicals is organized for the McNay Art Museum by Lyle W. Williams, Curator of Prints and Drawings, Curator of Modern Art; and Rafael Fernando Gutierrez Jr., the inaugural Douglass Foundation Intern in Curatorial Studies.
Hotel barge L’Impressionniste glides gently through the picturesque Ouche Valley in Southern Burgundy through locks with their charming lock houses. You will see medieval villages perched on hilltops and have the opportunity to discover a region famed for its history and viticulture, with visits to such places as Beaune, the regions ‘wine capital’, and the elegant city of Dijon.
What is hotel barging? Despite the growing popularity of cruising, especially on large river vessels, hotel barging is still a little known niche concept. Most hotel barges started life as cargo vessels but have since been painstakingly converted to offer luxury boutique accommodation for small groups of up to 20 passengers. This is cruising, but in a very different style to ships plying the big rivers or oceans.
The pace is slow, with a 6 day cruise covering maybe just 50 miles along a rural canal. Passengers can walk or bike the towpaths as their floating hotel glides gently along. Guests enjoy an intimate atmosphere, high levels of personal service and immersion into the culture, history and gastronomy of regions of Europe such as Burgundy, the Midi, or the Italian Veneto. Every day there is an excursion, perhaps to a chateau, a vineyard for a wine tasting, or some other ‘off the beaten track’ location.
About half of European Waterways’ bookings are for whole boat charters, ideal for families. Otherwise, clients book a cabin to join other like-minded people. A ‘slow boat’ European Waterways barge cruise offers the ultimate in experiential travel. A truly unique experience! European Waterways offer luxury hotel barge cruises on the beautiful canals and rivers of Europe, such as through Burgundy, the Midi, Alsace, the Po Valley, Holland and the Scottish Highlands.
The exclusive collection of hotel barges accommodate up to 20 passengers who may charter a whole barge with family or friends, or join a small group of like-minded travellers on an individual cabin basis. Each barge is fully crewed with a Captain, chef, hostesses, deck-hand and tour guide. The 6-night cruises include gourmet meals, fine wines, open bar, excursions and the use of facilities such as bicycles and spa pools.
With nearly 1,500 artworks on display, there is a lot to see at the Royal Academy of Arts (RA) Summer Exhibition 2022. If you want a taste of what’s on show then here is a quick tour. The theme chosen by the exhibition’s coordinator, Alison Wilding RA, is Climate. It begins outside, where a large-scale immersive installation by Spanish artist Cristina Iglesias brings nature and water to the courtyard. Inside, the artworks are spread over 11 rooms, including two galleries of prints selected by Grayson Perry RA.
Geiranger is a village in western Norway, at the head of Geirangerfjord. The Norwegian Fjord Center has multimedia on the history of the region and its inhabitants.
Video timeline: 00:00 Opening 00:28 Best view of the geiranger Fjord 01:04 Waterfalls and Mountain all around the Village 02:48 The Seven Sisters Waterfall 04:51 Farm Villages 06:16 Aerial View of Geiranger
Part of the steep Trollstigen mountain road weaves through the village, connecting to Flydalsjuvet lookout, which has views over the fjord. The fjord’s waterfalls, including the Seven Sisters, the Suitor and the Bridal Veil, are visible by boat.
Dubrovnik is a city in southern Croatia fronting the Adriatic Sea. It’s known for its distinctive Old Town, encircled with massive stone walls completed in the 16th century. Its well-preserved buildings range from baroque St. Blaise Church to Renaissance Sponza Palace and Gothic Rector’s Palace, now a history museum. Paved with limestone, the pedestrianized Stradun (or Placa) is lined with shops and restaurants.
The Bermuda Triangle, also known as the Devil’s Triangle, is an urban legend focused on a loosely-defined region in the western part of the North Atlantic Ocean where a number of aircraft and ships are said to have disappeared under mysterious circumstances.
For centuries, scientists have struggled to explain why hundreds of ships disappear when they reach the Bermuda Triangle. This area in the Atlantic Ocean is home to approximately 300 vessels, with several of these ships capsizing under mysterious circumstances. Today, experts are diving into these crystal clear waters to visit some of the abandoned shipwrecks and determine why they never made it to dry land.
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