Hundreds of miles south of Japan’s main islands, in the East China Sea, is a Jurassic Park of longevity, with a higher percentage of centenarians (people who live to 100 years old) than anywhere else on Earth.
Greg Dickinson visits the Japanese archipelago of Okinawa to discover the secret to long life.
Read the full article at: https://telegraph.co.uk/travel/destin…
Following the important publishing of “The Benefits Of Intermittent Fasting” study by Johns Hopkins in the New England Journal of Medicine on December 26, 2019, the 60-year old editor of Boomers-Daily.com (“B-D”) will launch, participate in, and document a decade-long, 18-Hour Intermittent Fasting Diet on December 30, 2019. The following protocol will be followed:
All readers of Boomers-Daily.com are encouraged to communicate with B-D and launch their own 18-hour Intermittent Fasting Diet (the 6-hour eating period can be varied 1-2 hours later or earlier). Please email boomersdaily@gmail.com to join the study, comment or inquire about this or your own 18-Hour Intermittent Fasting Diet. We will be looking to start an online chat room and other online platforms to increase the size, scope, visibility and transparency of the study over the next decade.
From a New England Journal of Medicine online release:
In humans, intermittent-fasting interventions ameliorate obesity, insulin resistance, dyslipidemia, hypertension, and inflammation. Intermittent fasting seems to confer health benefits to a greater extent than can be attributed just to a reduction in caloric intake.
Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, increased longevity, and a decreased incidence of diseases, including cancer and obesity.
Preclinical studies and clinical trials have shown that intermittent fasting has broad-spectrum benefits for many health conditions, such as obesity, diabetes mellitus, cardiovascular disease, cancers, and neurologic disorders. Animal models show that intermittent fasting improves health throughout the life span, whereas clinical studies have mainly involved relatively short-term interventions, over a period of months.
BOOMERS-DAILY.COM “18-HOUR INTERMITTENT FASTING DIET” STUDY
How much of the benefit of intermittent fasting is due to metabolic switching and how much is due to weight loss? Many studies have indicated that several of the benefits of intermittent fasting are dissociated from its effects on weight loss. These benefits include improvements in glucose regulation, blood pressure, and heart rate; the efficacy of endurance training; and abdominal fat loss.
Microbiome expands the genetic and functional capacity of its human host. Susan Lynch explains that human microbiome develops early in life and that gut microbes shape immune function and relate to disease outcomes in childhood.
She also explores next-generation microbiome therapeutics and research.
From a Genetic Engineering & Biotechnology News release:
“Our work provides additional evidence that that diet matters,” Millen added. “From a public health standpoint, we can tell people that if you have early AMD, it is likely in your best interest to limit your intake of processed meat, fried food, refined grains, and high-fat dairy to preserve your vision over time.”
Participants who ate a diet high in red and processed meat, fried food, refined grains, and high-fat dairy were three times more likely to develop an eye condition that damages the retina and affects a person’s central vision, according to the results of a study, “Diet patterns and the incidence of age-related macular degeneration in the Atherosclerosis Risk in Communities (ARIC) study,” from the University at Buffalo (UB) that appears in the British Journal of Ophthalmology.
The condition is called late-stage age-related macular degeneration (AMD), which is irreversible and affects a person’s central vision, taking away their ability to drive, among other common daily activities.
From a Cell Metabolism online study release:
Ten-hour time-restricted eating (TRE) limits daily dietary intake to a consistent 10-h window, creating a 14-h nightly fast. Researchers studied whether TRE for 12 weeks in people with metabolic syndrome receiving standard medical care (including medications to lower cholesterol and blood pressure) improves markers of health. TRE led to weight loss, healthier body composition (including decreased waist circumference), lower blood pressure and levels of cardiovascular disease-promoting lipids (i.e., “bad cholesterol” levels), and more restful sleep. TRE could be an effective dietary intervention to help those with metabolic syndrome.
Time-restricted eating (TRE) is an emerging dietary intervention that aims to maintain a consistent daily cycle of feeding and fasting to support robust circadian rhythms (Panda, 2016). Circadian regulation of the endocrine system, autonomic nervous system, and nutrient metabolism contributes to metabolic and physiological homeostasis (Asher and Sassone-Corsi, 2015,Panda, 2016). Both erratic eating patterns and eating over an extended period of time during the 24-h day can disrupt circadian rhythms.
To read entire study: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30611-4
From an Innova Market Insights online release:
According to a report from Innova Market Insights, snacking has already become an all-day habit in the States. While 46% of consumers eat salty snacks between-meals in the afternoon and 37% in the evening, more consumers are also replacing traditional meals with quicker bites. The numbers of consumers who are consuming salty snacks at lunchtime (23%), dinner (17%) and even breakfast (8%) are on the increase.
“Enjoyment is still a very strong driver behind snacks purchase,” says Lu Ann Williams, Head of Innovation at Innova Market Insights. “When asked why they buy salty snacks, 40% of Americans named taste and a further 22% said it was to treat or reward themselves, so innovators need to balance nutrition and taste to ensure that salty snacks remain competitive for all snacking occasions.”
To read more: https://www.innovamarketinsights.com/americans-want-snackable-nutrition/
From a Harvard news release:
…a new study from the Harvard John A. Paulson School for Engineering and Applied Sciences (SEAS) and Harvard’s Wyss Institute for Biologically Inspired Engineering has found that an orally administered liquid salt called Choline and Geranate (CAGE) can physically reduce the absorption of fats from food with no discernible side effects in rats, and reduces total body weight by about 12 percent.
“A reduction in body weight of 12 percent is like getting a human from 200 pounds down to 176, which is a significant change,” said first author Md Nurunnabi, a former Postdoctoral Fellow at the Wyss Institute and SEAS who is now an Assistant Professor of Pharmaceutical Sciences at The University of Texas at El Paso. “Our goal is to translate this work into a product that can help people maintain a healthier weight, and this study marks the very beginning of that journey.”
CAGE, which is a salt in its liquid state, was created a few years ago by Samir Mitragotri, the Hiller Professor of Bioengineering and Hansjörg Wyss Professor of Biologically Inspired Engineering, as part of an effort to improve the body’s absorption of medicines.
To read more: https://www.seas.harvard.edu/news/2019/11/locking-fats-cages-treat-obesity
From Sloan Kettering Institute:
Infections with the Enterococcus bacterium are a major threat in healthcare settings. They can lead to inflammation of the colon and serious illnesses such as bacteremia and sepsis, as well as other complications.
Now, an international team led by scientists from Memorial Sloan Kettering has shown for the first time that foods containing lactose, a sugar that’s naturally found in milk and dairy products, help Enterococcus thrive in the gut, at least in mice. They also studied changes in the bodies of people having BMTs. The study was published November 29 in Science.
Their previous research has shown that when harmless strains of microbes are wiped out, often due to treatment with antibiotics, Enterococcus and other harmful types of bacteria can take over due to lack of competition. As part of the new study, which included analysis of microbiota samples from more than 1,300 adults having BMTs, the team confirmed the link between Enterococcus and GVHD.
To read more: https://www.mskcc.org/blog/milking-it-study-mice-suggests-lactose-diet-feeds-dangerous-gut-bacteria?_subsite=research-ski
From a Stanford Medicine online news release:
“What you want is more, small fat cells rather than fewer, large fat cells,” Jackson said. “A large fat cell is not a healthy fat cell. The center is farther away from an oxygen supply, it sends out bad signals and it can burst and release toxic contents.” Large fat cells are associated with insulin resistance, diabetes and inflammation, he added.
Jackson and his colleagues found that when omega-3 fatty acids bind to a receptor called FFAR4 on the cilia of fat stem cells, it prompts the fat stem cells to divide, leading to the creation of more fat cells. This provides the body with more fat cells with which to store energy, something that is healthier than storing too much fat in existing fat cells.
For years, researchers have known that defects in an ancient cellular antenna called the primary cilium are linked with obesity and insulin resistance. Now, researchers at the Stanford University School of Medicine have discovered that the strange little cellular appendage is sensing omega-3 fatty acids in the diet, and that this signal is directly affecting how stem cells in fat tissue divide and turn into fat cells.
To read more: http://med.stanford.edu/news/all-news/2019/11/omega-3-fatty-acids-health-benefit-linked-to-stem-cell-control.html
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