Tag Archives: Choline & Geranate

Studies: Oral Liquid Salt Choline & Geranate (CAGE) Blocks Fat Absorption W/ 12% Weight Loss (Harvard)

From a Harvard news release:

Harvard John A. Paulson School of Engineering and Applied Sciences…a new study from the Harvard John A. Paulson School for Engineering and Applied Sciences (SEAS) and Harvard’s Wyss Institute for Biologically Inspired Engineering has found that an orally administered liquid salt called Choline and Geranate (CAGE) can physically reduce the absorption of fats from food with no discernible side effects in rats, and reduces total body weight by about 12 percent.

CAGE Harvard Study“A reduction in body weight of 12 percent is like getting a human from 200 pounds down to 176, which is a significant change,” said first author Md Nurunnabi, a former Postdoctoral Fellow at the Wyss Institute and SEAS who is now an Assistant Professor of Pharmaceutical Sciences at The University of Texas at El Paso. “Our goal is to translate this work into a product that can help people maintain a healthier weight, and this study marks the very beginning of that journey.”

CAGE, which is a salt in its liquid state, was created a few years ago by Samir Mitragotri, the Hiller Professor of Bioengineering and Hansjörg Wyss Professor of Biologically Inspired Engineering, as part of an effort to improve the body’s absorption of medicines.

To read more: https://www.seas.harvard.edu/news/2019/11/locking-fats-cages-treat-obesity