Harvard Medical School – A 13-year international study in mice demonstrates that loss of epigenetic information, which influences how DNA is organized and regulated, can drive aging independently of changes to the genetic code itself.
It also shows that restoring the integrity of the epigenome reverses age-related symptoms.
From acclaimed cultural and film historian James Curtis—a major biography, the first in more than two decades, of the legendary comedian and filmmaker who elevated physical comedy to the highest of arts and whose ingenious films remain as startling, innovative, modern—and irresistible—today as they were when they beguiled audiences almost a century ago.
The Drunken Boat: Selected Writings by Arthur Rimbaud, translated by Mark Polizzotti
Poet, prodigy, precursor, punk: the short, precocious, uncompromisingly rebellious career of the poet Arthur Rimbaud is one of the legends of modern literature. By the time he was twenty, Rimbaud had written a series of poems that are not only masterpieces in themselves but that forever transformed the idea of what poetry is. Without him, surrealism is inconceivable, and his influence is palpable in artists as diverse as Henry Miller, John Ashbery, Bob Dylan, and Patti Smith.
Russia claims control of Soledar but Ukraine remains silent. Meanwhile, is China pulling away from Russia and turning towards the Taliban? Plus: Pakistan receives a pledge of $9bn (€8.4bn) from the international community and a roundup from Art SG.
Federal prosecutors could decide soon whether to indict the president’s son on tax and gun charges, and he faces a fresh round of hostile congressional hearings. But a close look at his story shows that it differs in important ways from the narrative promoted by Republicans.
House Republicans are preparing a cascade of investigations, some overlapping, into the Biden administration and its policies. Right-wing lawmakers have said the ultimate goal is to impeach the president.