



Though a law requiring clinical trial results reporting has been on the books for decades, many researchers have been slow to comply. Now, 2 years after the law was sharpened with higher penalties for noncompliance, investigative correspondent Charles Piller took a look at the results. He talks with host Sarah Crespi about the investigation and a surprising lack of compliance and enforcement.
Also this week, Sarah talks with Brett Finlay, a microbiologist at the University Of British Columbia, Vancouver, about an Insight in this week’s issue that aims to connect the dots between noncommunicable diseases like heart disease, diabetes, and cancer and the microbes that live in our guts. Could these diseases actually spread through our microbiomes?
Getting into an MRI machine can be a tight fit for just one person. Now, researchers interested in studying face-to-face interactions are attempting to squeeze a whole other person into the same tube, while taking functional MRI (fMRI) measurements. Staff Writer Kelly Servick joins host Sarah Crespi to talk about the kinds of questions simultaneous fMRIs might answer.
Also this week, Sarah talks with Igor Grossman, director of the Wisdom and Culture Lab at the University of Waterloo, about his group’s Science Advances paper on public perceptions of the difference between something being rational and something being reasonable.
We start our first episode of the new year looking at future trends in policy and research with host Joel Goldberg and several Science News writers. Jeffrey Mervis discusses upcoming policy changes, Kelly Servick gives a rundown of areas to watch in the life sciences, and Ann Gibbons talks about potential advances in ancient proteins and DNA.
In research news, host Meagan Cantwell talks with Beatriz Pinto-Goncalves, a postdoctoral researcher at the John Innes Centre, about carnivorous plant traps. Through understanding the mechanisms that create these traps, Pinto-Goncalves and colleagues elucidate what this could mean for how they emerged in the evolutionary history of plants.
As the year comes to a close, we review the best science, the best stories, and the best books from 2019. Our end-of-the-year episode kicks off with Host Sarah Crespi and Online News Editor David Grimm talking about the top online stories on things like human self-domestication, the “wood wide web,” and more.
News Editor Tim Appenzeller joins Sarah to discuss Science’s 2019 Breakthrough of the Year, some of the contenders for breakthrough, also known as runners-up, and a breakdown—when science and politics just didn’t seem to mix this year.
Finally, Science books editor Valerie Thompson brings her favorites from the world of science-inflected media. She and Sarah talk about some of the best books reviewed in Science this year, a food extinction book we should have reviewed, a pair of science-centric films, and even an award-winning birding board game.
About one-third of people with epilepsy are treatment resistant. Up until now, epilepsy treatments have focused on taming seizures rather than the source of the disease and for good reason—so many roads lead to epilepsy: traumatic brain injury, extreme fever and infection, and genetic disorders, to name a few. Staff Writer Jennifer Couzin-Frankel talks with host Sarah Crespi about researchers that are turning back the pages on epilepsy, trying to get to the beginning of the story where new treatments might work.
And Sarah also talks with Torsten Neurbert at the Technical University of Denmark’s National Space Institute in Kongens Lyngby about capturing high-altitude “transient luminous events” from the International Space Station (ISS). These lightning-induced bursts of light, color, and occasionally gamma rays were first reported in the 1990s but had only been recorded from the ground or aircraft. With new measurements from the ISS come new insights into the anatomy of lightning.
Website: https://www.sciencemag.org/podcast/hunting-new-epilepsy-drugs-and-capturing-lightning-space
From a Science Magazine online article:
On 13 December, Amazon Prime will air the fourth season of The Expanse, a hardboiled space drama renowned for its working-class characters and real-world space physics. Showrunner Naren Shankar is part of the reason the science checks out. The veteran writer and producer for programs such as Star Trek: The Next Generation, Farscape, and the police procedural CSI: Crime Scene Investigation, has a doctorate in applied physics and electrical engineering.
Shankar chatted with Science about why he feels it’s important to have a realistic sci-fi show, and how television work is like the scientific peer-review process.
To read full interview: https://www.sciencemag.org/news/2019/12/how-real-world-science-sets-expanse-apart-other-sci-fi-shows?utm_campaign=news_weekly_2019-12-06&et_rid=600792821&et_cid=3113276
After their life as research subjects, what happens to lab monkeys? Some are euthanized to complete the research, others switch to new research projects, and some retire from lab life. Should they retire in place—in the same lab under the care of the same custodians—or should they be sent to retirement home–like sanctuaries? Online News Editor David Grimm joins host Sarah Crespi to discuss recently penned legislation that pushes for monkey retirements and a new collaboration between universities and sanctuaries to create a retirement pipeline for these primates.
Sarah also talks with Dante Lauretta, principal investigator for NASA’s Origins, Spectral Interpretation, Resource Identification, Security, Regolith Explorer (OSIRIS-REx) and a professor at the University of Arizona in Tucson, about the latest news from the asteroid Bennu. Within 1 week of beginning its orbit of the asteroid, OSIRIS-REx was able to send back surprising images of the asteroid ejecting material. It’s extremely rocky surface also took researchers by surprise and forced a recalculation of the sample return portion of the craft’s mission.
To read more: https://www.sciencemag.org/podcast/debating-lab-monkey-retirement-and-visiting-near-earth-asteroid
From a Science Magazine online article:
They found that these physically active mice had fewer inflammatory cells (leukocytes) than sedentary mice, an effect they traced to diminished activity of hematopoietic stem and progenitor cells (HSPCs). The lower activity of HSPCs was due at least in part to exercise-induced reduction in the levels of leptin, a hormone produced by fat tissue that regulates cells within the hematopoietic bone marrow niche.
Regular physical activity is associated with a lower rate of death from heart disease, but the underlying mechanisms are not fully understood. Frodermann et al. examined the effect of exercise on cardiovascular inflammation, a known risk factor for atherosclerosis, by studying mice that voluntarily ran for long distances on exercise wheels.
To read more: https://science.sciencemag.org/content/366/6469/1091.2
The National Institu
tes of Health’s largest loan repayment program was conceived to help scientists pay off school debts without relying on industry funding. But a close examination of the program by investigative correspondent Charles Piller has revealed that many participants are taking money from the government to repay their loans, while at the same time taking payments from pharmaceutical companies. Piller joins Host Sarah Crespi to talk about the steps he took to uncover this double dipping and why ethicists say this a conflict of interest.
Sarah also talks with Nate Lindsey, a Ph.D. candidate at the University of California, Berkeley, about turning a 50-meter undersea fiber optic cable designed to move data into a sensor for activity in the ocean and the land underneath. During a 4-day test in Monterey Bay, California, the cable detected earthquakes, faults, waves, and even ocean-going storms.
For this month’s books segment, Kiki Sandford talks with Dan Hooper about his book At the Edge of Time: Exploring the Mysteries of Our Universe’s First Seconds.