Tag Archives: Inflammation

Studies: Alcohol Abuse Increases Chronic Pain

Scripps Research (April 21, 2023) – Chronic alcohol consumption may make people more sensitive to pain through two different molecular mechanisms—one driven by alcohol intake and one by alcohol withdrawal. That is one new conclusion by scientists at Scripps Research on the complex links between alcohol and pain.

The research, published in the British Journal of Pharmacology on April 12, 2023, also suggests potential new drug targets for treating alcohol-associated chronic pain and hypersensitivity.

“There is an urgent need to better understand the two-way street between chronic pain and alcohol dependence,” says senior author Marisa Roberto, PhD, the Schimmel Family Chair of Molecular Medicine, and a professor of neuroscience at Scripps Research. “Pain is both a widespread symptom in patients suffering from alcohol dependence, as well as a reason why people are driven to drink again.”

Alcohol use disorder (AUD), which encompasses the conditions commonly called alcohol abuse, alcohol dependence and alcohol addiction, affects 29.5 million people in the U.S. according to the 2021 National Survey on Drug Use and Health.  Over time, AUD can trigger the development of numerous chronic diseases, including heart disease, stroke, liver disease and some cancers.

READ MORE AT SCRIPPS RESEARCH

Front Covers: Science Magazine – November 26

Science: Accupuncture’s Inflammation Effect, Antibiotics & Gut Bacteria

The neurons behind acupuncture’s effect on inflammation, and how antibiotics affect gut bacteria.

In this episode:

00:54 The neuronal basis for acupuncture’s effect on inflammation

In mice, electroacupuncture has been shown to reduce inflammation, but only when certain points on the body are stimulated. Why this is has puzzled scientists, but now, researchers have identified the specific neurons that are involved. They hope that this knowledge could be used in future to help treat certain inflammatory-related diseases.

Research article: Liu et al.

News and Views: Electroacupuncture activates neurons to switch off inflammation

07:28 Research Highlights

The Aztec origins of an obsidian ‘spirit mirror’, and the damage done by a Soviet plutonium complex.

Research Highlight: A ‘spirit mirror’ used in Elizabeth I’s court had Aztec roots

Research Highlight: Cold-war spy pictures reveal a Soviet nuclear ‘cloud generator’

10:18 Assessing antibiotics’ collateral damage.

Antibiotics are known to cause damage to the communities of bacteria that live in our guts. To better understand why this happens, a team has mapped the effects that different antibiotics have on individual gut-bacteria species, which may offer new insights into preventing this collateral damage.

Research article: Maier et al.

17:32 Briefing Chat

We discuss some highlights from the Nature Briefing. This time, the latest species to be declared extinct in the US, and a potential planet that orbits three stars.

New York Times: Protected Too Late: U.S. Officials Report More Than 20 Extinctions

New York Times: This May Be the First Planet Found Orbiting 3 Stars at Once

Health: Foods That Fight Inflammation (Harvard)

Covid-19 Analysis: The Negative Health Effects Of Microbiome Loss (PNAS)

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Health: ‘How Covid-19 Affects The Brain’ (Video)

New research could help explain why thousands of Covid-19 survivors are facing debilitating neurological symptoms months after initially getting sick. WSJ breaks down the science behind how the coronavirus affects the brain, and what this could mean for long-haul patients. Illustration: Nick Collingwood/WSJ