Meet the protein arsenal wielded by the pandemic virus
Authors were dropped from broader Lancet review
SARS-CoV-2 wields versatile proteins to foil our immune system’s counterattack
A fuel cell gains more power from ion-conducting, porous covalent organic frameworks
Following Russia’s invasion on February 24, the lives of scientists in Ukraine, like those of everyone else in the country, were upended. Russia has targeted educational and research institutions, destroying 285 buildings and damaging 2,528, according to the Ministry of Education and Science of Ukraine.
Despite enormous efforts, physicists are still struggling to create a complete theory of turbulent flows. Perhaps they need a change of perspective.
Forces involved in everyday activities become so familiar that we overlook how complicated they can be.
Storm surge is the deadliest part of a hurricane. Discover what causes this effect, and which regions are most at risk.
Storm surge is produced by water being pushed toward the shore by the force of the winds moving cyclonically around the storm. The impact on surge of the low pressure associated with intense storms is minimal in comparison to the water being forced toward the shore by the wind.
Wind and Pressure Components of Hurricane Storm Surge
The maximum potential storm surge for a particular location depends on a number of different factors. Storm surge is a very complex phenomenon because it is sensitive to the slightest changes in storm intensity, forward speed, size (radius of maximum winds-RMW), angle of approach to the coast, central pressure (minimal contribution in comparison to the wind), and the shape and characteristics of coastal features such as bays and estuaries.
Using electronic health records data from the All of Us Research Program, we show that higher daily step counts in data collected over several years of Fitbit fitness tracker use were associated with lower risk of common, chronic diseases, including diabetes, hypertension, gastroesophageal reflux disease, depression, obesity and sleep apnea.
Although questions remain about several diet and disease associations, current evidence supports dietary guidelines to limit red meat and increase vegetable intake.
Nature Medicine explores the latest translational and clinical research news, with an analysis of Intellia and Regeneron’s gene-editing treatment, which reduced levels of transthyretin in patients.
As humans live longer, they’re at increased risk of developing devastating NEURODEGENERATIVE diseases, such as Alzheimer’s—in a treatment landscape with few options and little hope. At Scripps Research, scientists are closer than ever to understanding how these diseases harm the brain and identifying possible drugs to stop them.
“This early preclinical work may identify proteins that protect against cognitive loss. We know it’s a long path to get to a drug, but we’re creating the foundation. We know there’s an entire landscape of potential molecular interactions that maintain healthy synapses, and any of these proteins could be a drug target.”— Hollis Cline, PhD
People vaccinated not long after being infected with SARS-CoV-2 mount a weaker immune response than do those whose infections are well behind them.
Modelling suggests that tree cutting is a greater threat to the Milne-Edwards’s sifaka than are climate extremes.
Providing the clean fuel to manufacturing plants would be a cost-effective way to tackle the country’s climate goals.
For the first time, scientists simulate the worldwide spread of the staggering wave triggered by the Chicxulub impact.
Take an animated look inside the neuron, and learn how scientists are addressing brain disease. With approximately 86 billion neurons in the brain, humans contain the most complex communications network imaginable. To address diseases of brain development and degeneration, neuroscientists are investigating how and why this network breaks down, and what can be done to repair it.
One area of study is dendrites, which are the tree-like structures of neurons, that receive electrical impulses. Researchers are carefully mapping out brain circuits and uncovering how connectivity changes can result in defects of the visual system or behavioral problems. The core section of the neuron is the cell body. Genetic engineering tools are revealing how mutations impact brain development and contribute to autism spectrum disorder or rare, inherited forms of neurological disease.
The transmission of nerve impulses occurs along the axon, which is insulated, much like an electrical wire, by a fatty layer called the myelin sheath. Scientists have invented a medicine to stop the immune system from mistakenly attacking this layer, which occurs during multiple sclerosis. Other molecules currently in development instruct the body to regenerate the sheath and repair damage. The axon also transports valuable cellular cargo, such as neurotransmitters, along tracks from one end of the neuron to the other.
Researchers are testing drug candidates for their ability to remove molecular traffic jams when this transport system fails, as often occurs in Parkinson’s and Alzheimer’s disease. The axon terminals make connections called synapses with other cells, using neurotransmitters as signals. Some scientists are evaluating how finely tuning the receptors for these chemicals could ease depression and anxiety.
Others are finding ways to promote the regrowth of lost synapses, which could halt neurodegeneration. From genetics to behavior, neuroscience is accelerating new interventions for the most challenging disorders of the nervous system.
Learn more: https://www.scripps.edu/
Trio helped launch new quantum revolution
By sequencing ancient hominins’ DNA, Pääbo explored “what makes us uniquely human”
Observers study debris from DART’s crash into a space rock and wait to see how much the asteroid was deflected
After NASA’s DART asteroid-deflection experiment, a fully funded telescope for detecting space rocks is an equally pressing priority.
Although the marine ‘carbon sink’ is bigger than expected, it is still inadequate to keep global warming at bay.
The rise in electric-vehicle ownership could overload the electric grid unless charging becomes a daytime activity.
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