Scientific American – January 2024 Preview
Tag Archives: Depression
BIPOLAR DISORDER: HOW IT IS DIAGNOSED & MANAGED
Chapters: 0:00 Intro 0:26 What is bipolar disorder? 0:50 What does a manic episode feel like? 1:18 What does a depressive episode feel like? 2:00 How to manage bipolar disorder
What is bipolar disorder?
Bipolar disorder (formerly known as manic-depressive illness or manic depression) is a lifelong mood disorder and mental health condition that causes intense shifts in mood, energy levels, thinking patterns and behavior. These shifts can last for hours, days, weeks or months and interrupt your ability to carry out day-to-day tasks.
There are a few types of bipolar disorder, which involve experiencing significant fluctuations in mood referred to as hypomanic/manic and depressive episodes. However, people with bipolar disorder aren’t always in a hypomanic/manic or depressive state. They also experience periods of normal mood, known as euthymia.
READ MORE at Cleveland Clinic
Previews: New Scientist Magazine- January 21, 2023
New Scientist Magazine – 21 January 2023:
Web3 promises to reclaim the internet from tech giants – will it work?
There’s a lot of hype surrounding the idea of a decentralised version of the internet that would give more power to ordinary users. Here’s what it would take to make it happen
Fresh ideas about the causes of depression are bringing new treatments
By upending the idea that a chemical imbalance in the brain is behind depression, we are starting to understand some of its mysteries and develop better treatments
How we finally tracked European eels all the way to the Sargasso Sea
Where European eels start and end their lives was long a mystery, but an audacious expedition has finally revealed the last details of their incredible migration
Health: Consequences Of Too Little Sleep (Harvard)
Treating Depression: Deep Brain Stimulation (UCSF)
UCSF Health physicians have successfully treated a patient with severe depression by tapping into the specific brain circuit involved in depressive brain patterns and resetting them using the equivalent of a pacemaker for the brain.
Depression: How Ketamine Can Help (Yale Medicine)
Depression is one of the most common and most debilitating mental health disorders, affecting some 17 million adults in the US. It also continues to be a misunderstood, often hard-to-treat illness. Researchers have worked for decades to better understand the neurobiology underpinning depression.
For patients with severe, treatment-resistant depression, spending months or even years searching for good treatments can be totally disabling. The prevailing hypothesis for years was that depression was regulated by the neurotransmitter’s serotonin and norepinephrine.
Eventually, data began to suggest that maybe something much larger and more global was involved in the brain to account for depression, which led researchers to begin working with glutamate and GABA, the most abundant neurotransmitters in the brain. These chemicals are involved in neuroplasticity – the brain’s ability to adapt to change and protect itself against stressful events.
Neuroplasticity is a physical thing, too: it manifests itself “in terms of synapses, how these neurons are actually touching each other and communicating with each other,” explains Gerard Sanacora, PhD, MD, Director of the Yale Depression Research Program. “And we know that in depression, the number and strength of these interconnections decreases,” says Rachel Katz, MD, a professor of Clinical Psychiatry at Yale.
Ketamine – originally developed and still used as an anesthetic – works on those two neurotransmitters and was discovered to have rapid antidepressant effects. Some experience an improvement in symptoms in 24 hours or less. “We think that one of the things that Ketamine does, that helps to explain its antidepressant effects, is help the brain to regrow the synapses, the connections between nerve cells,” says John Krystal, MD, Chair of the Department of Psychiatry at Yale.
Science Podcast: Botox & Depression, Fruit Fly Sex Drive And New Books
First this week, Contributing Correspondent Cathleen O’Grady talks with host Sarah Crespi about controversy surrounding the use of Botox injections to alleviate depression by suppressing frowning.
Next, researcher Stephen Zhang, a postdoctoral fellow at the Beth Israel Deaconess Medical Center, discusses his Science Advances paper on what turns on the fruit fly sex drive. Finally, we are excited to kick off a six-part series of monthly interviews with authors of books that highlight the many intersections between race and science and scientists. This week, guest host and journalist Angela Saini talks with Keith Wailoo, professor of history and public affairs at Princeton University, who helped select the topics about the books we will be covering and how they were selected.
Health: How Depression Affects The Brain (Yale)
For many people, depression turns out to be one of the most disabling illnesses that we have in society. Despite the treatments that we have available, many people are not responding that well. It’s a disorder that can be very disabling in society. It’s also a disorder that has medical consequences. By understand the neurobiology of depression we hope to be able more to find the right treatment for the patient suffering from this disease. The current standard of care for the treatment of depression is based on what we call the monoamine deficiency hypothesis. Essentially, presuming that one of three neurotransmitters in the brain is deficient or underactive. But the reality is, there are more than 100 neurotransmitters in the brain. And billions of connections between neurons. So we know that that’s a limited hypothesis. Neurotransmitters can be thought of as the chemical messengers within the brain, it’s what helps one cell in the brain communicate with another, to pass that message along from one brain region to another. For decades, we thought that the primary pathology, the primary cause of depression was some abnormality in these neurotransmitters, specifically serotonin or norepinephrine. However, norepinephrine and serotonin did not seem to be able to account for this cause, or to cause the symptoms of depression in people who had major depression. Instead, the chemical messengers between the nerve cells in the higher centers of the brain, which include glutamate and GABA, were possibilities as alternative causes for the symptoms of depression. When you’re exposed to severe and chronic stress like people experience when they have depression, you lose some of the connections between the nerve cells. The communication in these circuits becomes inefficient and noisy, we think that the loss of these synaptic connections contributes to the biology of depression. There are clear differences between a healthy brain and a depressed brain. And the exciting thing is, when you treat that depression effectively, the brain goes back to looking like a healthy brain, both at the cellular level and at a global scale. It’s critical to understand the neurobiology of depression and how the brain plays a role in that for two main reasons. One, it helps us understand how the disease develops and progresses, and we can start to target treatments based on that. We are in a new era of psychiatry. This is a paradigm shift, away from a model of monoaminergic deficiency to a fuller understanding of the brain as a complex neurochemical organ. All of the research is driven by the imperative to alleviate human suffering. Depression is one of the most substantial contributors to human suffering. The opportunity to make even a tiny dent in that is an incredible opportunity.SHOW LESS
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