Tag Archives: Vitamin D

Research Preview: Science Magazine – April 26, 2024

Science Magazine – April 25, 2024: The new issue features ‘Born to Explore’ – Exploratory tendency leads to diversification; Can science address loneliness?; Vitamin D, microbiota, and cancer immunity; A safer version of a 140-year-old chemical reaction…

Microbes and vitamin D aid immunotherapy

Vitamin D modulates intestinal epithelial cell function to enhance antitumor microbes

The gut microbiome has been shown to modulate the response of cancer patients to therapy, but precisely how microbiota affect anticancer immunity is still being elucidated. Giampazolias et al. report that vitamin D bioavailability in mice influences the composition of the gut microbiome (see the Perspective by Franco and McCoy). After dietary manipulation, vitamin D levels were observed to affect gut bacteria, which in turn improved cancer immunotherapy and antitumor immunity. In humans, low vitamin D levels were correlated with tumor development, and gene signatures of vitamin D activity were associated with improved patient responses to immunotherapy. These findings highlight the connection between vitamin D and the immune system through gut bacteria and may have applications for improving cancer therapies.

The power of curiosity

Lake Tanganyika contains one of the most impressive adaptive radiations, with about 250 species of cichlid occupying a variety of niches. Much research has focused on understanding the drivers of this and other adaptive radiations. Trembo et al. looked in depth at 57 of these cichlid species with regard to their behavior, ecomorphology, and genomics. They found that one behavior in particular, a tendency to explore, was related to niche adaptation, and they identified a regulatory gene that is highly associated with this behavior. These findings suggest the existence of an adaptive syndrome driven in part by a tendency to explore what is new.

Scientific American – January 2024 Preview

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Scientific American (December 19, 2023): The January 2024 issue features How Much Vitamin D Do You Need to Stay Healthy?; Inside Mathematicians’ Search for the Mysterious ‘Einstein Tile’; How Analyzing Cosmic Nothing Might Explain Everything; Why Are Alaska’s Rivers Turning Orange?; and Intervention at an Early Age May Hold Off the Onset of Depression…

Harvard Study: Vitamin D Lowers The Risk Of Young-Onset Colorectal Cancer

Science: Vitamin D Trial In Asthmatic Children, Risks to Machine Learning

Charles Piller, an investigative journalist for Science, talks with host Sarah Crespi about a risky trial of vitamin D in asthmatic children that has caused a lot of concern among ethicists.

They also discuss how the vitamin D trial connects with a possibly dangerous push to compare new treatments with placebos instead of standard-of-care treatments in clinical trials.

Next, Birhanu Eshete, professor of computer and information science at the University of Michigan, Dearborn, talks with producer Joel Goldberg about the risks of exposing machine learning algorithms online—risks such as the reverse engineering of training data to access proprietary information or even patient data.

Research: ‘The Science Of Healthy Aging’ (Scripps)

Although growing older comes with a number of major life changes, science can help inform the things we do in the here in and now to forestall the most serious features of the aging self, promoting healthspan and not just lifespan.

Summer 2021
  • Build Muscle – Muscle mass is one the best predictors of health and longevity. Muscle tissue is known to release its own chemicals called myokines, which can have benefits that span cognition, immunity and anti-cancer activity. By performing regular, resistance-based exercise that prioritizes strength, we can delay the loss of bone density and risk of physical injuries.
  • Vitamin D – Commonly known as the sunshine vitamin, vitamin D is in fact a critical hormone that helps maintain healthy bones, boost our immune system and improve our cardiovascular function. With age, the production of vitamin D in the skin can become less efficient, so if we don’t spend enough time outdoors, our risk of vitamin D deficiency may increase.
  • Neurodegenerative Diseases – One of the most unsettling aspects of aging is the potential for neurodegenerative disease. These conditions are increasingly prevalent in those with diabetes, suggesting that the brain’s blood flow and energy supply may be compromised. Research indicates that regular physical exercise, a healthy whole foods diet and staying intellectually active could at least slow the rate of decline.
  • Mindfulness – As we get older, major arteries can become thicker and less flexible, leading to increased blood pressure and undue strain on the heart. A regular mindfulness practice such as yoga or meditation has been shown to stem the release of stress hormones like cortisol and adrenaline. By freeing us from this “fight-or-flight” state, this habit can improve blood flow and reduce the risk of heart attack and stroke.
  • Stay Social – As social animals, maintaining a strong sense of community and close personal relationships into old age are underestimated contributors to longevity. While social isolation in seniors can result in significant physical and mental decline, research suggests that close loved ones offer important emotional support and behavioral modifications that can overcome periods of high stress.
  • Metabolism – “My metabolism is slowing down!” That’s what we often hear, as the aging body becomes less effective at using energy, placing us at risk of obesity and type 2 diabetes. By maintaining our muscle mass and reducing sugar consumption, we can support hormonal health, preserve our metabolism and keep our vitality into those advanced years. As scientists continue to find ways to extend our lives, paying attention to these keys to healthy aging can help increase the quality of those extra years.

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Health News Video: FDA Launches (And Explains) New Nutrition Facts Label

What’s new about the new Nutrition Facts label? Watch this Q&A with Susan T. Mayne, Ph.D., Director of FDA’s Center for Food Safety and Applied Nutrition. 

New FDA Nutrition Facts Label March 2020

For more information

Cancer Studies: Vitamin D Limits Melanoma Growth By Boosting Effects Of Immunotherapy

From a Genetic Engineering & Biotechnology News release:

Vitamin D Tames Melanoma“But what’s really intriguing is that we can now see how vitamin D might help the immune system fight cancer. We know when the Wnt/beta-catenin pathway is active in melanoma, it can dampen down the immune response causing fewer immune cells to reach the inside of the tumor, where they could potentially fight the cancer better.

“Although vitamin D on its own won’t treat cancer, we could take insights from the way it works to boost the effects of immunotherapy, which uses the immune system to find and attack cancer cells.”

Genetic Engineerin & Biotechnology News

In melanoma patients, elevated serum levels of vitamin D appear to be helpful. Tumors are thinner. Outcomes are improved. But how, exactly, are these benefits realized? To answer this question, researchers at the University of Leeds scrutinized the interaction between vitamin D and the vitamin D receptor (VDR) on melanoma cells. The researchers, fully aware that vitamin D on its own won’t treat cancer, hoped to identify cell signaling pathways that could lead to new therapeutic strategies.

To read more: https://www.genengnews.com/news/vitamin-ds-melanoma-taming-ways-uncovered/

Health Studies: Vitamin D Deficiency Can Increase Lower Back Pain, With Lower Muscle Strength

From a U.S. National Library of Medicine and National Institutes of Health release:

Vitamin D CapsulesIn people having lack of Vitamin D, the muscle strength of waist, back, neck decreases. Decreased muscle strength can cause herniated disc and cervical discal hernia. All of this is reflected in the patient’s pain. We wanted to pay attention to the necessity of considering the lack of Vitamin D in low back pain (LBP) which is one of the common complaints of our patients.

LBP and lack of vitamins are the most common health problems in our country and all over the world. The synthesis of >90% of Vitamin D in the body occurs under the influence of sunlight. Vitamin D, taken with foods, does not have a significant contribution, especially after a supplement is not taken. Seasonal and geographical changes are inevitable in the synthesis of Vitamin D in the derailment as the primary source is sunlight.[,,] The average prevalence in Vitamin D deficiency prevalence studies in the USA is reported as 41.6%, which is 82.1% in Black people and 69.2% in Hispanics.[] Hovsepian et al.[] reported a 50.8% prevalence of Vitamin D deficiency in the young adult population.

To read more click on the following link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157211/