Tag Archives: Health Studies

Health Reports: CDC Finds That 35,000 Americans Die Of Antibiotic-Resistant Infections Each Year

November 15, 2019 She Seeks Serene Leave a comment

More than 2.8 million antibiotic-resistant infections occur in the United States each year, and more than 35,000 people die as a result. In addition, nearly 223,900 people in the United States required hospital care for C. difficile and at least 12,800 people died in 2017.

Germs continue to spread and develop new types of resistance, and progress may be undermined by some community-associated infections that are on the rise. More action is needed to address antibiotic resistance. While the development of new treatments is one of these key actions, such investments must be coupled with dedicated efforts toward preventing infections in the first place, slowing the development of resistance through better antibiotic use, and stopping the spread of resistance when it does develop to protect American lives now and in the future.

CDC’s Antibiotic Resistance Threats in the United States, 2019 (2019 AR Threats Report) includes updated national death and infection estimates that underscore the continued threat of antibiotic resistance in the United States. New CDC data show that while the burden of antibiotic-resistance threats in the United States was greater than initially understood, deaths are decreasing since the 2013 report. This suggests that U.S. efforts—preventing infections, stopping spread of bacteria and fungi, and improving use of antibiotics in humans, animals, and the environment—are working, especially in hospitals. Vaccination, where possible, has also shown to be an effective tool of preventing infections, including those that can be resistant, in the community.

To read the report: https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf

Health, News, Studies

Health Studies: Chronic Inflammation Reduced By Exercise, Lowering Risk Of Cardiovascular Disease

November 8, 2019 She Seeks Serene Leave a comment

From a Harvard news online release:

“This study identifies a new molecular connection between exercise and inflammation that takes place in the bone marrow and highlights a previously unappreciated role of leptin in exercise-mediated cardiovascular protection,” said Michelle Olive, program officer at the National Heart, Lung, and Blood Institute Division of Cardiovascular Sciences. “This work adds a new piece to the puzzle of how sedentary lifestyles affect cardiovascular health and underscores the importance of following physical-activity guidelines.”

Scientists at Harvard-affiliated Massachusetts General Hospital (MGH) have identified a previously unknown biological pathway that promotes chronic inflammation and may help explain why sedentary people have an increased risk for heart disease and strokes.

In a study to be published in the November issue of Nature Medicine, MGH scientists and colleagues at several other institutions found that regular exercise blocks this pathway. This discovery could aid the development of new therapies to prevent cardiovascular disease.

Health, Sleep, Studies

Health Studies: Immune System Cells Rewire And Repair During Sleep

October 23, 2019 She Seeks Serene Leave a comment

From a Sleep Review Magazine online release:

The current study points to the role of norepinephrine, a neurotransmitter that signals arousal and stress in the central nervous system. This chemical is present in low levels in the brain while we sleep, but when production ramps up it arouses our nerve cells, causing us to wake up and become alert. The study showed that norepinephrine also acts on a specific receptor, the beta2 adrenergic receptor, which is expressed at high levels in microglia. When this chemical is present in the brain, the microglia slip into a sort of hibernation.

New research shows that immune cells called microglia—which play an important role in reorganizing the connections between nerve cells, fighting infections, and repairing damage—are primarily active during sleep.

The findings, which were conducted in mice and appear in the journal Nature Neuroscience, have implications for brain plasticity, diseases like autism spectrum disorders, schizophrenia, and dementia, which arise when the brain’s networks are not maintained properly, and the ability of the brain to fight off infection and repair the damage following a stroke or other traumatic injury.

Health, Studies

Studies: Antibiotics Impair Microbiome Composition, Reducing Flu Immunity

October 12, 2019 She Seeks Serene Leave a comment

From a Science Magazine online article:

Antibiotic use diminished the gut microbiome composition and impaired the ability of the immune system to generate antibodies. Treatment with antibiotics also disturbed bile acid metabolism and caused inflammatory responses.

From the original findings the Journal “Cell.com”:

Emerging evidence indicates a central role for the microbiome in immunity. However, causal evidence in humans is sparse. Here, we administered broad-spectrum antibiotics to healthy adults prior and subsequent to seasonal influenza vaccination. Despite a 10,000-fold reduction in gut bacterial load and long-lasting diminution in bacterial diversity, antibody responses were not significantly affected. However, in a second trial of subjects with low pre-existing antibody titers, there was significant impairment in H1N1-specific neutralization and binding IgG1 and IgA responses.

In addition, in both studies antibiotics treatment resulted in (1) enhanced inflammatory signatures (including AP-1/NR4A expression), observed previously in the elderly, and increased dendritic cell activation; (2) divergent metabolic trajectories, with a 1,000-fold reduction in serum secondary bile acids, which was highly correlated with AP-1/NR4A signaling and inflammasome activation. Multi-omics integration revealed significant associations between bacterial species and metabolic phenotypes, highlighting a key role for the microbiome in modulating human immunity.

Health, Studies

Health Studies: Epidemic Of Physical Inactivity, Processed Foods Results In “Stiffer Hearts” Which Compromises Endurance

September 17, 2019 She Seeks Serene Leave a comment

From Phys.org online article:

“As a result, today’s epidemic of physical inactivity in conjunction with highly processed, high-sodium diets contributes to thicker, stiffer hearts that compromise the heart’s ability to cope with endurance physical activity, and importantly this may start to occur prior to increases in resting blood pressure,” explains Shave.

The landmark study analyzed 160 humans, 43 chimpanzees and five gorillas to gain an understanding of how the heart responds to different types of physical activity. In collaboration with Harvard University’s Daniel Lieberman and Aaron Baggish, UBC Professor Robert Shave and colleagues compared left ventricle structure and function in chimpanzees and a variety of people, including some who were sedentary but disease-free, highly active Native American subsistence farmers, resistance-trained football linemen and endurance-trained long-distance runners.

Health, Studies

Health Studies: Reducing Skin Inflammation With “Topical Emollient” Cream Reduces Chronic Disease

September 16, 2019 She Seeks Serene Leave a comment

From a Wall Street Journal online article:

…a new small study in humans suggests that using a barrier-forming cream, such as those with an ingredient called ceramide, to treat and prevent problems associated with aging skin—such as dryness, itching and cracking—may help reduce the low-grade inflammation that occurs in otherwise healthy people as they age. Researchers from the University of California, San Francisco and the San Francisco Veterans Hospital say reducing age-related inflammation could help slow the progression of age-related disorders associated with chronic inflammation, such as Type 2 diabetes, heart disease and loss of muscle mass.

Systemic disease usually stems from multiple sources, so skin protection alone is unlikely to be a panacea, experts say. But the hope is that it can help slow the onset or progression of chronic conditions that often crop up in patients with skin disorders such as psoriasis. And the UCSF study, which was published in the Journal of the European Academy of Dermatology and Venereology in March, provides the first hint in humans that protecting the skin with a barrier cream might benefit otherwise healthy adults whose skin invariably starts to lose its barrier function around middle age.

To read PDF of study, click below:

https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.15540?referrer_access_token=lXsArqMcf5AHrI-R4oiwg4ta6bR2k8jH0KrdpFOxC67kdqa5-Q_Q8ltT6uQSa3kUEZMm6mEN7_8mvDywkPe9AOCn7aCLNi_CV3iAMck0BQxAu1SyLpdlTkFwF7hXxUCR6TazFFGPRwZ_EfW2P-26dA%3D%3D

Health, Reviews, Studies

Health Of The Elderly: Hearing Loss Is Resulting In Severe Loneliness, Depression And Demetia

September 15, 2019 She Seeks Serene Leave a comment

From an NPR online article:

There may be no easy fix for the loneliness epidemic plaguing the nation, but helping people cope with hearing loss could be one key to tackling this complex problem. Hearing loss affects 1 of every 5 people and is strongly linked to loneliness: Every decibel drop in perception in people under 70 increases the odds of becoming severely lonely by 7%, one Dutch study showed.

As hearing declines, loneliness can intensify — and set off a cascade of detrimental health effects. Now considered as hazardous as smoking 15 cigarettes a day, loneliness vastly raises the risks of depression, dementia and early death.

Yet the vast majority of people who suffer from hearing loss don’t know they have a problem — or don’t want to know. The changes happen gradually, and often earlier than expected.

Diet, Health, Studies

Nutrional Health Studies: Mediterranean Diet Improves Cognitive Function In Older People

September 11, 2019 She Seeks Serene Leave a comment

From a Nutritional Neuroscience online release:

Our findings suggest that higher adherence to a Mediterranean diet is associated with better cognitive performance, and therefore less cognitive decline, in older but not middle-aged individuals.

Over a period of five years, higher adherence to a Mediterranean diet was associated with improvements in Global Cognitive Function, Visual-Spatial Organisation and Memory and scanning and tracking in participants ≥70 years.

Adherence to a Mediterranean diet is associated with higher cognitive function and reduced risk of dementia in Mediterranean populations. However, few studies have investigated the association between Mediterranean diet adherence and cognition in populations outside of the Mediterranean basin.

Health, Studies

Health Studies: Majority Of People With Dementia Never Receive Specialty Diagnosis Or Care

September 6, 2019 She Seeks Serene Leave a comment

From a USC News online release:

The team found 85% of people first diagnosed with dementia were diagnosed by a non-dementia specialist physician, usually a primary care doctor, and an “unspecified dementia” diagnosis was common.

One year after diagnosis, less than a quarter of patients had seen a dementia specialist. After five years, the percent of patients had only increased to 36%.

In the first large study to examine the diagnosis of dementia in older Americans over time, researchers found the vast majority never meet with a dementia specialist and are instead overwhelmingly diagnosed and cared for by non-specialists.

The study, which also found the use of dementia specialty care was particularly low for Hispanic and Asian patients, was published Wednesday in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.

Health, Studies

Health Studies: Early Heart Disease Is Related More To Poor Lifestyle Choices Than Genetics

September 3, 2019 She Seeks Serene Leave a comment

From a ScienceDaily.com online release:

Physical inactivity, smoking, high blood pressure, diabetes, and high cholesterol play a greater role than genetics in many young patients with heart disease, according to research presented today at ESC Congress 2019 together with the World Congress of Cardiology. The findings show that healthy behaviours should be a top priority for reducing heart disease even in those with a family history of early onset.

The study enrolled 1,075 patients under 50, of whom 555 had coronary artery disease (known as premature CAD). Specific conditions included stable angina, heart attack, and unstable angina. The average age was 45 and 87% were men. Risk factor levels and genetics in patients were compared to a control group of 520 healthy volunteers (average age 44, and 86% men). Patients and controls were recruited from the Genes in Madeira and Coronary Disease (GENEMACOR) database.

Five modifiable risk factors were assessed: physical inactivity, smoking, high blood pressure, diabetes, and high cholesterol. Nearly three-quarters (73%) of patients had at least three of these risk factors compared to 31% of controls. In both groups, the likelihood of developing CAD increased exponentially with each additional risk factor. The probability of CAD was 3, 7, and 24 times higher with 1, 2, and 3 or more risk factors, respectively.