Tag Archives: Covid-19 Vaccines

Covid-19: How BioNTech Used Its Cancer Research To Create A Vaccine (CNBC)

Over a month and a half before the World Health Organization officially declared a pandemic, BioNTech CEO Uğur Şahin met with his wife, BioNTech’s co-founder and chief medical officer Özlem Türeci, and together they agreed to redirect most of the company’s resources to developing a vaccine. Up until that point, BioNTech was little-known internationally and primarily focused on developing novel cancer treatments. The founders were confident in the potential of their mRNA technology, which they knew could trigger a powerful immune response. That confidence wasn’t necessarily shared by the broader medical community. No mRNA vaccine or treatment had ever been approved before. But the couple’s timely breakthrough was actually decades in the making. CNBC spoke with Şahin and Türeci about how they, along with Pfizer, created a Covid-19 vaccine using mRNA.

Covid-19: Vaccine For Children Nears Approval

As the FDA nears a decision on authorizing Pfizer’s Covid-19 vaccine for children 5-11 years old, public-health officials and pediatricians are sharing research with families to assure hesitant parents of the shot’s safety. Photo: John Locher/Associated Press

Infographic: Vaccination Effect On Covid-19 Deaths

Morning News: America’s Vaccine Mandate, Cities Shift & Ancient Finland

President Joe Biden’s requirements for employers to insist on vaccinations are a bold move amid flatlining inoculation rates. But will they work?

For decades the world’s cities seemed invincible, but the pandemic has hastened and hardened a shift in urban demographics and economics. And an ancient Finnish burial site scrambles notions of gender roles in the distant past.

Covid-19: The Booster Shot Debate (CNBC Video)

The delta variant of Covid-19 took the U.S. by surprise. Months after the first vaccines rolled out, Covid-19 infections surged as the delta variant overwhelmed the unvaccinated population and even broke through the immunity from the shots from Moderna, Pfizer and Johnson & Johnson. Now, the White House has a new plan to fight the delta variant, including booster shots and vaccine mandates. Here’s where we stand in the debate over booster shots, and in the fight against the delta variant.

Analysis: Covid-19 Vaccine Efficacy Explained (Video)

Recent studies have shown that the effectiveness of Covid-19 vaccines is decreasing, though experts say the shots still work well. WSJ explains what the numbers mean and why they don’t tell the full story. Photo illustration: Jacob Reynolds/WSJ

Analysis: How Moderna & Pfizer-BioNTech Created Vaccines In Record Time

The decision to pivot an entire business to focus on the coronavirus is an obvious one in hindsight, at least for Moderna, BioNTech and Pfizer, which succeeded beyond anyone’s expectations — and will reap billions of dollars in sales of their vaccines this year alone.

It wasn’t such a clear decision in the early months of 2020, though that’s when Moderna’s chief executive, Stephane Bancel, and BioNTech’s chief, Ugur Sahin, starting turning their ships, they told CNBC in interviews for this documentary about the vaccine race, produced by CNBC senior health and science reporter Meg Tirrell and senior digital producer Sam Rega.

“The night that China locked down Wuhan, I’m like: ‘When was the last time I know a city has been locked down because of an infectious disease?’” Bancel recalled. “And what goes through my mind is: what do the Chinese know that we don’t know?“ Bancel said he awoke sweating at 4 a.m., realizing, “Jeez, there’s going to be a pandemic like 1918.” For Sahin, it was reading a paper in the Lancet in late January describing the outbreak in China.

“I did a number of calculations, fast calculations, and realized it had already spread,” Sahin said. “And it was clear that it was already too late to stop the disease.” But he was convinced BioNTech, then focused mainly on personalized cancer therapies, may be able to do something. His company reached out to Pfizer, he said, proposing to work on a vaccine for the novel coronavirus using the same technology, messenger RNA, on which they’d already partnered to try to tackle the flu.

“We had the first contact a few days after starting the project,” Sahin said. “At that time, Pfizer was not yet interested.” Albert Bourla, Pfizer’s CEO, confirmed Sahin’s account, saying in the earliest months of 2020, he was focused on maintaining the company’s operations in China. But by late February, he said, he’d determined Pfizer needed to work on a treatment and a vaccine.

“What is the best approach?” Bourla said he asked his team. Kathrin Jansen, head of Pfizer’s vaccine research and development, said they assessed all existing technologies, including protein-based vaccines and vaccines using viral vectors. “They all have too few pros and too many cons,” she said.

But messenger RNA was a risk; it had never been used before as an approved vaccine or drug. “I wrestled a little bit with the decision,” Bourla said. But after another meeting with the team, “they convinced me.” That’s when Sahin called a second time. The outbreak, by that point, was already in New York, he said. Reaching Jansen, he described the work that BioNTech already had underway, and asked if Pfizer would like to work together. “And I said: absolutely,” Jansen remembered. “Let’s talk about this.”

At Moderna, it was never a question that messenger RNA would be the way forward; that was the technology around which the company was founded in 2010. But that didn’t mean questions didn’t exist. “Even going into March, there were voices that said vaccines were false hope,” recalled Dr. Stephen Hoge, Moderna’s president.

“It did feel for a period of time that we needed to defend even the idea of trying.” “When we were thinking about how do we get into Phase 1, what does it look like to prepare for a pandemic, the eyes of the world felt as though they were looking at Moderna as this biotech … ‘what are they trying to do?’” said Hamilton Bennett, Moderna’s senior director of vaccine access and partnerships.

“It was only when we transitioned in that March notification from the WHO that this was a global pandemic, it’s an emergency, that I think people started to realize that what we’re doing isn’t playing in a sandbox trying to demonstrate our technology,” Bennett said. “We’re developing a vaccine that’s going to stop the pandemic.” The companies succeeded, in what became one of the greatest medical races in history. Here, they recall how it happened.

Covid-19: Can Vaccines Keep Up With Variants?

The race between covid-19 vaccines and variants is on. Alok Jha, The Economist’s science correspondent, and Natasha Loder, health policy editor, discuss what this means for the future Read more of our coverage on coronavirus: https://econ.st/3t1L6wx

Covid-19: Patients Dying In Name Of Vaccine Freedom

In the video above, Alexander Stockton, a producer on the Opinion Video team, explores two of the main reasons the number of Covid cases is soaring once again in the United States: vaccine hesitancy and refusal. “It’s hard to watch the pandemic drag on as Americans refuse the vaccine in the name of freedom,” he says. Seeking understanding, Mr. Stockton travels to Mountain Home, Ark., in the Ozarks, a region with galloping contagion and — not unrelated — abysmal vaccination rates. He finds that a range of feelings and beliefs underpins the low rates — including fear, skepticism and a libertarian strain of defiance. This doubt even extends to the staff at a regional hospital, where about half of the medical personnel are not vaccinated — even while the intensive care unit is crowded with unvaccinated Covid patients fighting for their lives. Mountain Home — like the United States as a whole — is caught in a tug of war between private liberty and public health. But Mr. Stockton suggests that unless government upholds its duty to protect Americans, keeping the common good in mind, this may be a battle with no end.

Morning News: Airlines To Aid Refugees, Vaccinating Youths, Blue-Light Glasses

A.M. Edition for Aug. 23. WSJ’s Karina Shah looks at where different countries stand with youth vaccination rates. The Pentagon orders U.S. airlines to help evacuate Americans and Afghan partners from the country. 

At least 21 people are dead after flash flooding in Tennessee. Tropical Depression Henri makes landfall. Bitcoin miners go elsewhere amid a crackdown in China. And, blue-light glasses: a fashion accessory or a necessity?