“Roughly two and a half years into the pandemic, White House officials and health experts have reached a pivotal conclusion about Covid-19 vaccines: The current approach of offering booster shots every few months isn’t sustainable.
Though most vaccines take years to develop, the Covid shots now in use were created in record time—in a matter of months. For health authorities and a public desperate for tools to deal with the pandemic, their speedy arrival provided a huge lift, preventing hospitalizations and deaths while helping people to escape lockdowns and return to work, school and many other aspects of pre-Covid life.”
Enter the intranasal vaccine, which abandons the needle and syringe for a spray container that looks more like a nasal decongestant. With a quick spritz up the nose, intranasal vaccines are designed to bolster immune defenses in the mucosa, triggering production of an antibody known as immunoglobulin A, which can block infection. This overwhelming response, called sterilizing immunity, reduces the chance that people will pass on the virus.
The development of highly effective COVID vaccines in less than a year is an extraordinary triumph of science. But several coronavirus variants have emerged that could at least partly evade the immune response induced by the vaccines. These variants should serve as a warning against complacency—and encourage us to explore a different type of vaccination, delivered as a spray in the nose. Intranasal vaccines could provide an additional degree of protection, and help reduce the spread of the virus.