Tag Archives: Brain

Neuroscience: “What Is It Like To Have Synesthesia?” (The Royal Institution)

Can you imagine if each word had its own colour, or you could ‘see’ different types of music?

Synesthetes can experience the ordinary world in some pretty extraordinary ways. In this video Jamie Ward explains the variety of different ways in synesthesia can manifest itself, and what is happening in the brains of those who experience it.

Jamie Ward is Professor of Cognitive Neuroscience at the University of Sussex. He has written books a number of books about neuroscience and synesthesia.

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Synesthesia is a perceptual phenomenon in which stimulation of one sensory or cognitive pathway leads to involuntary experiences in a second sensory or cognitive pathway. People who report a lifelong history of such experiences are known as synesthetes. Awareness of synesthetic perceptions varies from person to person.[7] In one common form of synesthesia, known as grapheme–color synesthesia or color–graphemic synesthesia, letters or numbers are perceived as inherently colored. In spatial-sequence, or number form synesthesia, numbers, months of the year, or days of the week elicit precise locations in space (for example, 1980 may be “farther away” than 1990), or may appear as a three-dimensional map (clockwise or counterclockwise). Synesthetic associations can occur in any combination and any number of senses or cognitive pathways.

From Wikipedia

Studies: Elderly In 3rd Highest Level Of Exercise Reduce Brain Shrinkage, Aging By 4 Years (AAN)

From a March 5, 2020 American Academy of Neurology release:

American Academy of Neurology (AAN) Logo“These results are exciting, as they suggest that people may potentially prevent brain shrinking and the effects of aging on the brain simply by becoming more active,” said study author Yian Gu, Ph.D., of Columbia University in New York and a member of the American Academy of Neurology.

“Recent studies have shown that as people age, physical activity may reduce the risk of cognitive decline and dementia. Our study used brain scans to measure the brain volumes of a diverse group of people and found that those who engaged in the top third highest level of physical activity had a brain volume the equivalent of four years younger in brain aging than people who were at the bottom third activity level.”

Older people who regularly walk, garden, swim or dance may have bigger brains than their inactive peers, according to a preliminary study to be presented at the American Academy of Neurology’s 72nd Annual Meeting in Toronto, Canada, April 25 to May 1, 2020. The effect of exercise was equal to four fewer years of brain aging. The study used magnetic resonance imaging (MRI) scans to measure the brains of people with a range of activity levels, including those who were inactive to those who were very active. The scans showed less active people had smaller brain volume.

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Intense (VO2peak) Aerobic Exercise Raises Cognition, Alzheimer’s Disease Risks Lowered In Older Adults

From the Brain Plasticity Journal (Dec 26, 2019):

Brain Plasticity Journal 2020In conclusion, increased CRF (cardiorespiratory fitness) following this six-month intervention was associated with enhanced brain glucose metabolism in the PCC (posterior cingulate cortex), a region linked to AD, and cognition among late-middle-aged individuals at risk for AD. If these findings are supported by a larger-scale study, this would provide strong evidence that adults at risk for AD may enhance brain function and cognition by engaging in aerobic exercise training.

PCC glucose metabolism correlated positively with change in VO2peak (the highest value of VO2 attained upon an incremental or other high-intensity exercise test, designed to bring the sub- ject to the limit of tolerance)…Improvement in executive function correlated with increased VO2peak. Favorable CRF adaptation after 26 weeks of aerobic exercise training was associated with improvements in PCC glucose metabolism and executive function, important markers of AD.

Aerobic exercise has been associated with reduced burden of brain and cognitive changes related to Alzheimer’s disease (AD). However, it is unknown whether exercise training in asymptomatic individuals harboring risk for AD improves outcomes associated with AD. We investigated the effect of 26 weeks of supervised aerobic treadmill exercise training on brain glucose metabolism and cognition among 23 late-middle-aged adults from a cohort enriched with familial and genetic risk of AD.

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New Books On Ageing: “The Changing Mind” By Daniel Levitin (February 2020)

The Changing Mind A Neuroscientist's Guide To Ageing Well Daniel Levitin Feb 2020Challenging widely held assumptions about the diminishing abilities of an ageing brain, leading neuroscientist Daniel Levitin argues that we should view getting older as a beneficial experience rather than a form of cognitive entropy. Persuasively argued and consistently surprising, The Changing Mind will alter your perception of the relationship between age and intellect.

We have long been encouraged to think of old age as synonymous with deterioration. Yet, recent studies show that our decision-making skills improve as we age and our happiness levels peak in our eighties. What really happens to our brains as we get older?

More of us are living into our eighties than ever before. In The Changing Mind, neuroscientist, psychologist and internationally-bestselling author Daniel Levitin invites us to dramatically shift our understanding of growing older, demonstrating its many cognitive benefits. He draws on cutting-edge research to challenge common and flawed beliefs, including assumptions around memory loss and the focus on lifespan instead of ‘healthspan’.

Levitin reveals the evolving power of the human brain from infancy to late adulthood. Distilling the findings from over 4000 papers, he explains the importance of personality traits, lifestyle, memory and community on ageing, offering actionable tips that we can all start now, at any age.

Featuring compelling insights from individuals who have thrived far beyond the conventional age of retirement, this book offers realistic guidelines and practical cognition-enhancing tricks for everyone to follow during every decade of their life. This is a radical exploration of what we all can learn from those who age joyously.

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Excerpts: Chip Walter On The “Search For The Aging Cure” (“Immortality, Inc.”)

From a LitHub online article by Chip Walter, 69:

Immortality Inc Chip Walter bookAnd what if older neurons were replaced wholesale with new stem cells? They might scramble different sectors of the brain by destroying the new connections between the originals. Fiddle with those, and who knew what mayhem might follow? Memories, learning, and other cerebral functions that the brain had grown accustomed to might simply vanish. On the other hand, in the case of a disease like Alzheimer’s, maybe new memories would be better than no memories at all.

Robert Hariri’s views on human health began to take an unusual turn a little more than 25 years ago, when he was working as a neurosurgeon and trauma doctor at the New York Hospital-Cornell Medical Center. Day after day, he watched patients come into the emergency room with severe brain injuries, and it was a painful thing to witness.

He never forgot the case of a woman who had arrived after a senseless automobile accident. She was young, and the injury was bad. Every time he spoke with the family, the big questions they asked were: “How will she be? Will she come back? Could she be a mother to her children again?” It broke his heart.

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William J. (Chip) Walter Jr. (born May 23, 1951) is an author, journalist, National Geographic Fellow, educator, filmmaker and former CNN bureau chief. He has written five mainstream science books between 1991 and 2019. Walter was one of the original employees at Cable News Network when it went on the air June 1, 1980 and later became its youngest bureau chief when he created CNN’s first Southeast Bureau in 1981 before heading up the network’s San Francisco Bureau in 1982. He has written and produced several PBS science documentaries, served as an adjunct professor at Carnegie Mellon University in three different departments, worked with UNICEF on the issue of childhood trauma, spoken at Harvard, Xerox PARC, Carnegie Mellon University and the Chautauqua Institution. One of his three original screenplays was produced and released under the title Sunset Grill in 1993 starring Peter Weller, Lori Singer and Stacy Keach. In 2015 his feature story for National Geographic Magazine explored the origins of human art and symbolic thinking.

From Wikipedia

Medical Procedures: How “Gamma Knife” Surgery Treats Brain Tumors

It’s called gamma knife surgery, but there’s no cutting involved. It’s been used at Mayo Clinic for 30 years as an alternative to open brain surgery.

The patient’s head is held still during the procedure with a headframe, which also serves as a map for the radiation. Using 3D imaging — typically an MRI — as a guide, the gamma knife is targeted directly at the tumor. And with no hospital stay and minimal side effects, it’s a procedure that is efficient and can be lifesaving.

Health: Characteristics Of Neurodegenerative Diseases (Mayo Clinic)

Dr. Nilüfer Ertekin-Taner, neurogeneticist and behavioral neurologist, discusses characteristics of neurodegenerative diseases such as dementia, Alzheimer’s disease, and movement disorders. She also discusses her research on the complex genetics of Alzheimer’s disease, including identifying therapeutic targets and biomarkers. She highlights Mayo Clinic’s unique approach to patient care.

Health Infographics: How Exercise Creates “New Neurons In Aging Brains”

New Neurons in Aging Brains Scientific American January 2020 Tami Tolpa

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Researchers have also documented clear links between aerobic exercise and benefits to other parts of the brain, including expansion of the prefrontal cortex, which sits just behind the forehead. Such augmentation of this region has been tied to sharper executive cognitive functions, which involve aspects of planning, decision-making and multitasking—abilities that, like memory, tend to decline with healthy aging and are further degraded in the presence of Alzheimer’s. Scientists suspect that increased connections between existing neurons, rather than the birth of new neurons, are responsible for the beneficial effects of exercise on the prefrontal cortex and other brain regions outside the hippocampus.

Scientific American article

Health: “Digestion And The Brain” (Harvard Podcast)

Most of the time your digestive tract toils silently in the background, routinely taking in nourishment and expelling waste. But here’s a key takeaway: Your brain is a critical part of maintaining this smoothly running system. 

Here to explain is Harvard professor Dr. Lawrence S. Friedman, faculty editor the special health report Sensitive Gut.

Medical Research Video: “Synthesizing Speech From Brain Signals” (JAMA)

Imagine you’re paralyzed and can’t move or speak. How would you communicate with the world? This video describes the principles of early brain-computer interfaces (BCIs) designed to read electrical brain signals, analyze how brain activity patterns contribute to vocal tract movements, and reproduce the sound patterns as speech. The model is a first step toward one day restoring paralyzed individuals’ natural rate of communication and quality of life.

For more information see https://ja.ma/37dfVSx and https://www.nature.com/articles/s4158….