Category Archives: Research

Healthy Living: Can The Aging Process Be Halted?

Can the aging process be reversed – or even halted, altogether? If we manage to decode this final mystery of our human biology, we might soon be able to eradicate age-related illnesses like cancer, dementia and heart problems. The race to invent the miracle pill is well underway.

Today, international researchers are getting astonishingly close to realizing humanity’s dream of immortality. The hunt for immortality gained traction with the discovery of Costa Rica’s so-called “Blue Zone,” by Luis Rosero-Bixby. In the “Blue Zone,” on the Nicoya Peninsular, he found a remarkable number of centenarians.

Here, male life expectancy is the highest in the world. Their healthy lifestyle is one factor, but the promise of longevity is probably also because their telomeres – sections of DNA found at the end of chromosomes – are longer than those of the average person. It’s a field of research currently being explored by Maria Blasco in Madrid.

But this is just one of many possible factors influencing the process of aging. Senescent cells may also play a key role. Also known as “zombie cells”, these attack our body in old age and flood it with alarm signals until, at some point, we collapse under their weight. That’s a theory proposed by another researcher in Spain, Manuel Serrano. A billion-dollar industry is already knocking impatiently at the lab doors.

The first to market the miracle pill is guaranteed incredible wealth. That’s why investors are sponsoring young bio-startups in Hong Kong. Keen not be left out, US Big Tech is vying for the world’s best scientists. Alex Zhavoronkov has secured a slice of that pie, with a cash injection of more than 250 million dollars for his company’s work on aging research. Whereas some pioneers’ visions burst like bubbles, others rush to get other, rather more dubious products onto the market. But their efficacy is now measurable.

The epigenetic clock devised by Steve Horvath can measure our biological age, regardless of our actual age in years. With his research on the thymus gland, California’s Greg Fahy managed to not only decelerate the aging process, but reverse it. His initial study on humans showed that a particular drug cocktail took an average two-and-a-half years off their age.

Young biohackers like Nina Khera from Boston want everyone to benefit from this research. Together with friends, she’s working on the “epigenetic clock for all”. But while we’re busy trying to counter the aging process and all the illnesses it entails, fundamental questions arise: Should we be messing with nature like this? Are we about to overwhelm the planet with more and more people? Criminal biologist Mark Benecke in Cologne says that these questions are coming far too late.

Cover Preview: Nature Magazine – May 26, 2022

Volume 605 Issue 7911

Fluid dynamics

Cilia are characterized by slender, threadlike projections, which are used by biological organisms to control fluid flows at the microscale. Attempts to mimic these structures and engineer cilia-like systems to have broad applications have proved problematic. In this week’s issue, Wei Wang and colleagues present electronically controlled artificial cilia that can be used to create flow patterns in near-surface liquids. The researchers use surface-mounted platinum strips, each about 50 micrometres long, 5 micrometres wide and 10 nanometres thick, and capped on one side with titanium. Applying an oscillating potential with an amplitude of around 1 volt to the cilia drives ions on to and off of the exposed platinum surface. These ions create asymmetric forces that generate a beating pattern that can be used to pump surface liquids in various flow geometries. The cover shows an artist’s impression of the artificial cilia in action.

Science: Fossil Mystery Solved, A Silk Mother Of Pearl, Bolivian Amazon

The puzzle of PalaeospondylusOver a hundred years ago, archaeologists discovered fossils of the aquatic animal Palaeospondylus. But since then researchers have been unable to place where this animal sits on the tree of life. Now, new analysis of Palaeospondylus’s anatomy might help to solve this mystery.

08:18 Research Highlights

A strong, silk-based version of mother of pearl, and the parrots that use their heads when climbing.

Research Highlight: Silk imitates mother of pearl for a tough, eco-friendly material

Research Highlight: A ‘forbidden’ body type? These parrots flout the rules

10:51 How lasers revealed an ancient Amazonian civilization

Archaeologists have used LiDAR to uncover evidence of an ancient civilization buried in the Bolivian Amazon. The team’s work suggests that this area was not as sparsely populated in pre-Hispanic times as previously thought.

Research article: Prümers et al.

News and Views: Large-scale early urban settlements in Amazonia

Nature Video: Lost beneath the leaves: Lasers reveal an ancient Amazonian civilisation

16:21 Briefing Chat

We discuss some highlights from the Nature Briefing. This time, the debate surrounding the first transplant of pig kidneys into humans, and the plants grown in lunar soil.

Nature News: First pig kidneys transplanted into people: what scientists think

Cover Preview: Science Magazine – May 20, 2022

Enhanced charge density wave coherence in a light-quenched, high-temperature superconductor

The deubiquitinase USP8 targets ESCRT-III to promote incomplete cell division

All topological bands of all nonmagnetic stoichiometric materials

Cover Preview: Nature Magazine – May 19, 2022

Nature Magazine, May 19, 2022 – At industrial scales, chemical reactions are typically driven by applying continuous heat to the reactants. In this week’s issue, Liangbing Hu and his colleagues show that pulsed heating and quenching can enhance synthetic performance while also saving energy.

Volume 605 Issue 7910

The researchers use a programmable electric current to switch between high and low temperatures very quickly — typically 0.02 seconds on, 1.08 seconds off. Rapidly quenching the reaction gives high selectivity, maintains catalyst stability and reduces energy usage. The cover image illustrates the heater in action for the pyrolysis of methane — the model reaction the team tested. Methane molecules travel through the pores of the high-temperature heater and are selectively converted into useful products.

Previews: New Scientist Magazine – May 21, 2022

COVER STORIES

  • CULTURE Regenesis review: Farming is killing the planet but we can stop it
  • FEATURES Why the next big solar storm might hit Earth without warning
  • FEATURES The female body is misunderstood and this is why, says Rachel E. Gross
  • FEATURES How the massive dogs bred to protect livestock could save wolves too

Science: Galaxies Without Dark Matter, High Helium Levels, Solar Energy Jump

Dark matter makes up most of the matter in the Universe, and is thought to be needed for galaxies to form. But four years ago, astronomers made a perplexing, and controversial discovery: two galaxies seemingly devoid of dark matter. 

This week the team suggests that a cosmic collision may explain how these, and a string of other dark-matter-free galaxies, could have formed.

Research article: van Dokkum et al

News and Views: Giant collision created galaxies devoid of dark matter

08:39 Research Highlights

How fossil fuel burning has caused levels of helium to rise, and a high-efficiency, hybrid solar-energy system.

Research Highlight: Helium levels in the atmosphere are ballooning

Research Highlight: Flower power: ‘Sunflower’ system churns out useful energy

10:49 Researchers experiences of the war in Ukraine

We hear the stories of scientists whose lives have been affected by Russia’s invasion of Ukraine, including researchers who have become refugees, soldiers and activists in the face of a horrifying conflict.

Nature Feature: How three Ukrainian scientists are surviving Russia’s brutal war

20:46 Imaging the black hole at the centre of the Milky Way

Last week, a team of researchers released an image of Sagittarius A*, the supermassive blackhole at the centre of our galaxy. We hear how they took the image and what it is revealing about these enormous objects.

Nature News: Black hole at the centre of our Galaxy imaged for the first time

Brain Health: The Benefits Of Intermittent Fasting

Although intermittent fasting is most widely known as a weight-loss strategy, emerging research suggests that it could have benefits for brain health and cognition. But does it actually work, are there any drawbacks and how long would you have to fast to see benefits? WSJ’s Daniela Hernandez breaks down what’s known and what’s not about the neuroscience of intermittent fasting.

Timeline: 0:00 Could intermittent fasting help our brains work better and longer? 0:31 How long would you have to fast to see any potential cognitive benefits? 1:04 How intermittent fasting could affect your ability to focus 2:27 Potential mood-related benefits of intermittent fasting 2:48 How intermittent fasting can affect brain health 4:03 Potential drawbacks of intermittent fasting

Cover Preview: Science Magazine – May 13, 2022

A survey of cell types across tissues as part of the Human Cell Atlas, mapped with single-cell transcriptomics in three papers in this issue, lays the foundation for understanding how cellular composition and gene expression vary across the human body in health, and for understanding how genes act in disease.