“This study identifies a new molecular connection between exercise and inflammation that takes place in the bone marrow and highlights a previously unappreciated role of leptin in exercise-mediated cardiovascular protection,” said Michelle Olive, program officer at the National Heart, Lung, and Blood Institute Division of Cardiovascular Sciences. “This work adds a new piece to the puzzle of how sedentary lifestyles affect cardiovascular health and underscores the importance of following physical-activity guidelines.”
Scientists at Harvard-affiliated Massachusetts General Hospital (MGH) have identified a previously unknown biological pathway that promotes chronic inflammation and may help explain why sedentary people have an increased risk for heart disease and strokes.
In a study to be published in the November issue of Nature Medicine, MGH scientists and colleagues at several other institutions found that regular exercise blocks this pathway. This discovery could aid the development of new therapies to prevent cardiovascular disease.
This week our correspondent joined Emmanuel Macron on his visit to China. The French president is stretching his diplomatic wings, and has some striking views about Europe’s place in the world. The state of Texas has been reliably Republican for decades, but its demographics are changing; could it at last turn blue? And how Japan is dealing with its epidemic of public-transport groping.
Recent polls in early voting states show Pete Buttigieg’s popularity surging among Democratic voters. The mayor of South Bend, Indiana, is now in the top tier of candidates vying for the chance to challenge President Trump in the 2020 presidential election. But with that growing support comes rising scrutiny. Judy Woodruff talks to Buttigieg about health care, taxes and uniting a divided country.
Listen to the latest science updates, with Benjamin Thompson and Shamini Bundell. This week, insights into the evolution of walking upright, how science needs to change in the next 150 years, and the remaining hurdles for vaccination.
This year is Nature’s 150th anniversary. Science has made huge strides during this time, but what needs to change to continue this progress for the next 150 years? Comment: Science must move with the times
17:52 The state of vaccination in 2019
Researchers assess the differences in immunization levels worldwide and identify the bottlenecks in developing new vaccines. Research article: Piot et al.
NPR’s Tamara Keith and Amy Walter of the Cook Political Report join Amna Nawaz to discuss the latest political news, including the release of transcripts from the impeachment inquiry, what three upcoming gubernatorial races say about President Trump’s support, early polling in key 2020 battleground states and the waning distinction between local and national politics.
One hundred years ago this month, you opened the shutters of a small bookshop on rue Dupuytren. Its name was Shakespeare and Company. I often wonder if, on that first morning, you could ever have imagined how important your story would be.
You were only 32 but had already lived quite a life. Soulful and fearless, witty and energetic, you’d been active in the women’s suffrage movement, studied French poetry in Paris, and served with the Red Cross in Serbia during the First World War. You had also met Adrienne Monnier, one of the first women in France to found her own bookshop. Adrienne would be your companion for decades to come.
Your bookshop—first on rue Dupuytren, then around the corner on rue de l’Odéon—became a sanctuary for Anglophone and Francophone writers. T.S. Eliot, Gertrude Stein, Ezra Pound, James Joyce, Ernest Hemingway, Djuna Barnes, and F. Scott Fitzgerald, as well as André Gide, Paul Valéry, and Louis Aragon, among many others, all bought and borrowed books from you, and attended readings and parties at Shakespeare and Company. As André Chamson wrote about you: “Sylvia Beach carried pollen like a bee. She cross-fertilised these writers. She did more to link England, the United States, Ireland, and France than four great ambassadors combined.” I think of this whenever I ponder the role booksellers and bookshops can play during this age of political and ecological turbulence. When James Joyce couldn’t find anyone to publish Ulysses—his modernist masterpiece that had been condemned for obscenity—you stepped up. Even when you closed your bookshop in 1941, it was not an act of defeat but of defiance—you would rather see your life’s work shuttered forever than sell Finnegans Wake to a high-ranking Nazi officer.
Sylvia Whitman
When my father, George Whitman, opened this bookshop in 1951, you were not just a regular visitor but an inspiration. You had shown how a true bookseller must also be prepared to be a librarian, a publisher, a PO box, a banker, a hotelier, and—most importantly—a friend to writers and readers. For your belief that a love of reading is more important than the quest for profit, you have been called the patron saint of independent bookstores. We’re sure that your extraordinary memoir and your beautiful letters continue to embolden booksellers the world over, just as they embolden us. Particularly during hard times, your story stands like a beacon when we need direction, comfort, or inspiration.
Thank you, Sylvia, for everything you did and everything you stood for.
“This is the fourth time in the last two years we’ve had to activate our hospital’s emergency operations plan for a major drug shortage,” Dr. Biddinger told NBC News. “It’s almost unfathomable in modern medicine. I never thought we would get to a point in the U.S. healthcare system where we wouldn’t have essential medicines to be able to treat patients.”
Drug shortages are increasing and lasting longer, according to an FDA report published Oct. 29. Of 163 drugs running low in 2013-17, over 62 percent were due to manufacturing or product quality problems.
Hospitals nationwide are facing shortages of crucial, lifesaving drugs, with 116 drugs currently running low, according to the FDA and cited byNBC News.
Boston-based Massachusetts General Hospital is a prime example, getting as close as two weeks away from canceling a lifesaving cardiac surgery due to a lack of herapin, a blood-thinner, according to Paul Biddinger, MD, chief of the division of emergency preparedness at Massachusetts General Hospital.
“The results we saw were stunning and suggest that holistically addressing aging via gene therapy could be more effective than the piecemeal approach that currently exists,” said first author Noah Davidsohn, a former research scientist at the Wyss Institute and HMS who is now chief technology officer of Rejuvenate Bio. “Everyone wants to stay as healthy as possible for as long as possible, and this study is a first step toward reducing the suffering caused by debilitating diseases.”
New research from the Wyss Institute for Biologically Inspired Engineering at Harvard University and Harvard Medical School (HMS) suggests that it may be possible someday to tend to multiple ailments with one treatment.
The study was conducted in the lab of Wyss core faculty member George Church as part of Davidsohn’s postdoctoral research into the genetics of aging. Davidsohn, Church, and their co-authors homed in on three genes that had been shown to confer increased health and lifespan benefits in mice that were genetically engineered to overexpress them: FGF21, sTGFβR2, and αKlotho. They hypothesized that providing extra copies of those genes to nonengineered mice via gene therapy would similarly combat age-related diseases and bring health benefits.
“Another behavior change is physical exercise,” Pillemer said. “A paradox of pain is that exercise helps reduce it, but it’s difficult for people in pain to think about exercising. So they don’t exercise, they get more sedentary and the pain increases; it’s a vicious circle. So how do you get people to actually change their behavior?”
More than 100 million Americans suffer from chronic pain – outnumbering those affected by heart disease, diabetes and cancer combined.
To develop innovative approaches to pain management, a team of behavioral and social science researchers on Cornell’s Ithaca campus, clinical researchers at Weill Cornell Medicine and computer scientists at Cornell Tech has received a five-year, $3 million grant from the National Institute on Aging, part of the National Institutes of Health (NIH).