Category Archives: Biology

2023: Top Discoveries In Biology & Neuroscience

Quanta Magazine (December 21, 2023): 2023’s Biggest Breakthroughs in Biology and Neuroscience.

Video timeline: 00:05 The Investigation of Consciousness – Our minds are constantly taking in new external information while also creating their own internal imagery and narratives. How do we distinguish reality from fantasy? This year, researchers discovered that the brain has a “reality threshold” against which it constantly evaluates processed signals. Original paper: “Subjective signal strength distinguishes reality from imagination”

04:30 Microbiomes Evolve With Us – This year, scientists provided clear evidence that the organisms in our microbiome —the collection of bacteria and other cells that live in our guts and elsewhere on our body — spread between people, especially those with whom we spend the most time. This raises the intriguing possibility that some illnesses that aren’t usually considered communicable might be.

08:43 How Life Keeps Time – The rate at which an embryo develops and the timing of when its tissues mature vary dramatically between species. What controls the ticking of this developmental clock that determines an animal’s final form? This year, a series of careful experiments suggest that mitochondria may very well serve dual roles as both the timekeeper and power source for complex cells.

Health: How Organs In Our Bodies Age Over Time

WIRED (November 13, 2023) – Dr. Jeffrey Laitman joins WIRED to break down how our organs and body parts age from head to toe. From hearing and hair loss to sagging skin and deteriorating joints, Dr. Laitman highlights the impact of aging on the human body—and what we can do about it.

Director: Lisandro Perez-Rey; Director of Photography: Francis Bernal

Research: Lena Pernas PhD On ‘How Mitochondria Protects Us From Disease’

TEDx Talks (November 4, 2023) – Approximately 1.5 billion years ago, a lone bacterium found its way into a larger cell. The exchanges that transpired between the two are considered to have driven the evolution of this bacterium into the organelle we now call the mitochondrion.

Emerging research suggests that mitochondria are not simply the ‘powerhouses’ of the cell, but also function as cellular guardians against microbial intruders. Consequently, maintaining mitochondrial health is not only vital for our well-being, but may serve to protect us against infectious disease.

Dr. Lena Pernas started as a Max Planck Research Group Leader at the MPI Biology for Ageing (Cologne, Germany) in late 2018, where her lab investigates the organelle and metabolic dynamics of the host-pathogen interaction. Her lab will open its doors at UCLA in the Metabolism Research Theme in 2023.

Immunity: How T Cells And B Cells Fight Infections

nature video (March 15, 2023) – Lymphocytes are immune cells that play vital roles in fighting infections. The most well-known lymphocytes are the T cells and B cells of the adaptive immune system. In the 1950s and 1960s, scientists performed experiments to follow lymphocytes on their journey around the body, which helped us to work out where they go and what they do.

This work laid the foundation for everything we know about T cells today, including how they become activated to fight infections and how they form memory populations that provide long-lasting immunity.

CRISPR Technology: Dr. Jennifer Doudna On Its Medical Ethics (Video)

Dr. Jennifer Doudna first made her name uncovering the basic structure and function of the first ribozyme, a type of catalytic ribonucleic acid (RNA) that helps catalyse chemical reactions. This work helped lay the foundation for her later helping to pioneer CRISPR-Cas 9, a tool that has provided the means to edit genes on an unprecedented scale and at minimal cost. In addition to her scientific contributions to CRISPR, Doudna is known for spearheading the public debate to consider the ethical implications of using CRISPR-Cas9 to edit human embryos.

Biotechnology: ‘Genome Sequencing – Unlocking The Covid Code’ (NY Times)

The advent of commercial genome sequencing has recently, and credibly, been compared to the invention of the microscope, a claim that led me to wonder whether this new, still relatively obscure technology, humming away in well-equipped labs around the world, would prove to be the most important innovation of the 21st century.

And unexpectedly, Covid-19 has proved to be the catalyst. “What the pandemic has done is accelerate the adoption of genomics into infectious disease by several years,” says deSouza, the Illumina chief executive. He also told me he believes that the pandemic has accelerated the adoption of genomics into society more broadly — suggesting that quietly, in the midst of chaos and a global catastrophe, the age of cheap, rapid sequencing has arrived.

Read full article in the NY Times

Healthy Lives: Living In Sych With Biological Clocks (Salk Institute)

Satchin Panda is a professor in Salk’s Regulatory Biology Laboratory. He explores the genes, molecules and cells that keep the whole body on the same biological clock, also known as a circadian rhythm. On this episode of Where Cures Begin, Panda talks about what a biological clock is, how living in sync with your clock can improve your health, and how growing up in India informed his research.

Science: ‘Insane Biology Of Ant Colonies’ (4K Video)

Ants are social insects which form small to large colonies. A typical colony contains an egg-laying queen and many adult workers together with their brood (eggs, larvae and pupae). Workers are by far the most numerous individuals in the nest. They are responsible for nest construction and maintenance, foraging, tending the brood and queen, and nest defence.

While all workers are female, they are sterile and do not lay eggs. Winged queens and males are present in the nest for only a short period. Soon after emerging they leave the nest to mate and establish new nests. Queens are generally similar to the workers, differing primarily in having larger bodies. In some species, fully winged queens are lacking and egg-laying is undertaken either by typical workers or by individuals which are morphologically intermediate between typical queens and workers (these are called ergatoid queens). Males are generally about the same size as the workers or smaller, and have smaller heads with large ocelli, very short scapes and small mandibles. In many cases males look more like wasps than ants.