A Nature special issue – 20 October 2022:
Science is “a shared experience, subject both to the best of what creativity and imagination have to offer and to humankind’s worst excesses”. So wrote the guest editors of this special issue of Nature, Melissa Nobles, Chad Womack, Ambroise Wonkam and Elizabeth Wathuti, in a June 2022 editorial announcing their involvement.
Andre Terzic, M.D., Ph.D., a Mayo Clinic cardiologist
Regenerative medicine could slow the clock on degenerative diseases that often ravage the golden years, a Mayo Clinic study finds. Life span has nearly doubled since the 1950s, but health span — the number of disease-free years — has not kept pace. According to a paper published in NPJ Regenerative Medicine., people are generally living longer, but the last decade of life is often racked with chronic, age-related diseases that diminish quality of life. These final years come with a great cost burden to society.
Researchers contend that new solutions for increasing health span lie at the intersection of regenerative medicine research, anti-senescent investigation, clinical care and societal supports. A regenerative approach offers hope of extending the longevity of good health, so a person’s final years can be lived to the fullest.
Meet the protein arsenal wielded by the pandemic virus
Authors were dropped from broader Lancet review
SARS-CoV-2 wields versatile proteins to foil our immune system’s counterattack
A fuel cell gains more power from ion-conducting, porous covalent organic frameworks
Following Russia’s invasion on February 24, the lives of scientists in Ukraine, like those of everyone else in the country, were upended. Russia has targeted educational and research institutions, destroying 285 buildings and damaging 2,528, according to the Ministry of Education and Science of Ukraine.
Despite enormous efforts, physicists are still struggling to create a complete theory of turbulent flows. Perhaps they need a change of perspective.
Forces involved in everyday activities become so familiar that we overlook how complicated they can be.
People vaccinated not long after being infected with SARS-CoV-2 mount a weaker immune response than do those whose infections are well behind them.
Modelling suggests that tree cutting is a greater threat to the Milne-Edwards’s sifaka than are climate extremes.
Providing the clean fuel to manufacturing plants would be a cost-effective way to tackle the country’s climate goals.
For the first time, scientists simulate the worldwide spread of the staggering wave triggered by the Chicxulub impact.
Take an animated look inside the neuron, and learn how scientists are addressing brain disease. With approximately 86 billion neurons in the brain, humans contain the most complex communications network imaginable. To address diseases of brain development and degeneration, neuroscientists are investigating how and why this network breaks down, and what can be done to repair it.
One area of study is dendrites, which are the tree-like structures of neurons, that receive electrical impulses. Researchers are carefully mapping out brain circuits and uncovering how connectivity changes can result in defects of the visual system or behavioral problems. The core section of the neuron is the cell body. Genetic engineering tools are revealing how mutations impact brain development and contribute to autism spectrum disorder or rare, inherited forms of neurological disease.
The transmission of nerve impulses occurs along the axon, which is insulated, much like an electrical wire, by a fatty layer called the myelin sheath. Scientists have invented a medicine to stop the immune system from mistakenly attacking this layer, which occurs during multiple sclerosis. Other molecules currently in development instruct the body to regenerate the sheath and repair damage. The axon also transports valuable cellular cargo, such as neurotransmitters, along tracks from one end of the neuron to the other.
Researchers are testing drug candidates for their ability to remove molecular traffic jams when this transport system fails, as often occurs in Parkinson’s and Alzheimer’s disease. The axon terminals make connections called synapses with other cells, using neurotransmitters as signals. Some scientists are evaluating how finely tuning the receptors for these chemicals could ease depression and anxiety.
Others are finding ways to promote the regrowth of lost synapses, which could halt neurodegeneration. From genetics to behavior, neuroscience is accelerating new interventions for the most challenging disorders of the nervous system.
Learn more: https://www.scripps.edu/
Trio helped launch new quantum revolution
By sequencing ancient hominins’ DNA, Pääbo explored “what makes us uniquely human”
Observers study debris from DART’s crash into a space rock and wait to see how much the asteroid was deflected
After NASA’s DART asteroid-deflection experiment, a fully funded telescope for detecting space rocks is an equally pressing priority.
Although the marine ‘carbon sink’ is bigger than expected, it is still inadequate to keep global warming at bay.
The rise in electric-vehicle ownership could overload the electric grid unless charging becomes a daytime activity.
Even mild COVID-19 is at least correlated with a startlingly wide spectrum of seemingly every illness. We need a much better taxonomy to address people’s suffering.
From The Atlantic, October 5, 2022:
The cases of long covid that turn up in news reports, the medical literature, and in the offices of doctors like me fall into a few rough (and sometimes overlapping) categories. The first seems most readily explainable: the combination of organ damage, often profound physical debilitation, and poor mental health inflicted by severe pneumonia and resultant critical illness.
This serious long-term COVID-19 complication gets relatively little media attention despite its severity. The coronavirus can cause acute respiratory distress syndrome, the gravest form of pneumonia, which can in turn provoke a spiral of inflammation and injury that can end up taking down virtually every organ. I have seen many such complications in the ICU: failing hearts, collapsed lungs, failed kidneys, brain hemorrhages, limbs cut off from blood flow, and more. More than 7 million COVID-19 hospitalizations occurred in the United States before the Omicron wave, suggesting that millions could be left with damaged lungs or complications of critical illness. Whether these patients’ needs for care and rehabilitation are being adequately (and equitably) met is unclear: Ensuring that they are is an urgent priority.
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