Tag Archives: Chronic Disease

Aging: How Regenerative Medicine Slows The Clock

“Diverse aging populations, vulnerable to chronic disease, are at the cusp of a promising future. Indeed, growing regenerative options offer opportunities to boost innate healing, and address aging-associated decline. The outlook for an extended well-being strives to achieve health for all,”

Andre Terzic, M.D., Ph.D., a Mayo Clinic cardiologist

Regenerative medicine could slow the clock on degenerative diseases that often ravage the golden years, a Mayo Clinic study finds. Life span has nearly doubled since the 1950s, but health span — the number of disease-free years — has not kept pace. According to a paper published in NPJ Regenerative Medicine., people are generally living longer, but the last decade of life is often racked with chronic, age-related diseases that diminish quality of life. These final years come with a great cost burden to society.

Researchers contend that new solutions for increasing health span lie at the intersection of regenerative medicine research, anti-senescent investigation, clinical care and societal supports. A regenerative approach offers hope of extending the longevity of good health, so a person’s final years can be lived to the fullest.

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Health: Nature Medicine Magazine – October 2022

Volume 28 Issue 10

Association of step counts over time with the risk of chronic disease in the All of Us Research Program

Using electronic health records data from the All of Us Research Program, we show that higher daily step counts in data collected over several years of Fitbit fitness tracker use were associated with lower risk of common, chronic diseases, including diabetes, hypertension, gastroesophageal reflux disease, depression, obesity and sleep apnea.

Meat, vegetables and health — interpreting the evidence

Although questions remain about several diet and disease associations, current evidence supports dietary guidelines to limit red meat and increase vegetable intake.

CRISPR–Cas9 hits its target in amyloidosis

Nature Medicine explores the latest translational and clinical research news, with an analysis of Intellia and Regeneron’s gene-editing treatment, which reduced levels of transthyretin in patients.

Nature Medicine Website

New Study: Nearly 50% Of Americans Will Have Obesity By 2030, 25% Severely Obese (NEJM)

From a New England Journal of Medicine online study release:

The findings from our approach suggest with high predictive accuracy that by 2030 nearly 1 in 2 adults will have obesity (48.9%; 95% confidence interval [CI], 47.7 to 50.1), and the prevalence will be higher than 50% in 29 states and not below 35% in any state.

New England Journal of Medicine logo

Nearly 1 in 4 adults is projected to have severe obesity by 2030 (24.2%; 95% CI, 22.9 to 25.5), and the prevalence will be higher than 25% in 25 states. We predict that, nationally, severe obesity is likely to become the most common BMI category among women (27.6%; 95% CI, 26.1 to 29.2), non-Hispanic black adults (31.7%; 95% CI, 29.9 to 33.4), and low-income adults (31.7%; 95% CI, 30.2 to 33.2).

Projected National Prevalence of BMI Categories in 2030, According to Demographic Subgroup. New England Journal of Medicine December 2019

Although severe obesity was once a rare condition, our findings suggest that it will soon be the most common BMI category in the patient populations of many health care providers. Given that health professionals are often poorly prepared to treat obesity,27 this impending burden of severe obesity and associated medical complications has implications for medical practice and education.

In addition to the profound health effects, such as increased rates of chronic disease and negative consequences on life expectancy,25,28 the effect of weight stigma29 may have far-reaching implications for socioeconomic disparities as severe obesity becomes the most common BMI category among low-income adults in nearly every state.

To read more: https://www.nejm.org/doi/full/10.1056/NEJMsa1909301?query=featured_home