

Structural biologists rejoiced when cryo–electron microscopy, a technique to generate highly detailed models of biomolecules, emerged. But years after its release, researchers still face long queues to access these machines. Science’s European News Editor Eric Hand walks host Meagan Cantwell through the journey of a group of researchers to create a cheaper, more accessible alternative.

Also this week, host Joel Goldberg speaks with psychiatrist and researcher Goodman Sibeko, who worked with the Xhosa people of South Africa to help illuminate genetic details of schizophrenia. Though scientists have examined this subject among Western populations, much less is known about the underlying genetics of people native to Africa.
Listen to the latest from the world of science, with Benjamin Thompson and Nick Howe. This week, establishing climate change’s role in Australian bushfires, and revisiting Isaac Asimov’s thoughts robots.In this episode:
Researchers are working to establish the role that climate change is playing in the bushfires that are raging across Australia. News Feature: The race to decipher how climate change influenced Australia’s record fires; Editorial: Australia: show the world what climate action looks like
The debate around how Vesuvius claimed its victims, and an ancient mummy speaks. Research Highlight: Vitrified brains and baked bones tell the story of Vesuvius deaths; Research Article: Howard et al.
This year marks the centenary of Isaac Asimov’s birth. We reflect on the impact of his writing on the field of robotics. Essay: Isaac Asimov: centenary of the great explainer
The latest on a new virus from Wuhan in China, and social scientists’ battle with bots. News: Coronavirus: latest news on spreading infection; News: Social scientists battle bots to glean insights from online chatter
A method for printing 3D objects that can control living organisms in predicable ways has been developed by an interdisciplinary team of researchers at MIT and elsewhere. This technique may lead to 3D printing of biomedical tools that can be customized to fit the physical body and biomarkers of its users.

(Learn more: http://news.mit.edu/2020/3-d-bioprint…)
Listen to an explainer on 3D bioprinting and biohybrid materials: https://soundcloud.com/mitnewsoffice/…
Hear the latest science news, brought to you by Nick Howe and Benjamin Thompson. This week, why stress makes mice turn grey, and how to think about climate change.
In this episode:
Anecdotal evidence has long suggested stress as a cause of grey hair. Now, a team of researchers have showed experimental evidence to suggest this is the case. Research Article: Zhang et al.; News & Views: How the stress of fight or flight turns hair white
Ancient bones suggest that giant ground sloths moved in herds, plus an atomic way to check for whiskey fakes. Research Highlight: A bone bed reveals mass death of herd of giant ground sloths; Research Highlight: Nuclear-bomb carbon unmasks fraudulent luxury whisky
To tackle climate change, the former UN secretary for climate change argues that the biggest change needs to be mindset. Comment: Paris taught me how to do what is necessary to combat climate change
The latest on a new virus from Wuhan in China, and insights from ancient African genomes. News: China virus latest: first US case confirmed; Research Article: Lipson et al.
From a New Atlas online article:
Scientists have just discovered a new mechanism that can be key in regulating these immune attacks, raising new hopes of drugs that can protect against joint inflammation and the ailments it can bring.
Through the use of the CRISPR gene-editing tool, the Karolinska Institutet scientists have now shed further light on the role they play in inflammation. The technology enabled the team to make adjustments to a set of hand-picked immune cell genes as a way of learning how those tweaks can impact the behavior of the cells.
“The results we obtained using CRISPR were key to quickly understanding how the system under study is regulated,” says Dr Wermeling. “I have high hopes that the experimental use of CRISPR will be hugely important to our understanding of how immune-cell behavior is regulated, and that this can guide us in the development of new efficacious drugs.”
A rising world population means we’ll need more food in the coming years. But much of our food relies on insect pollination, and insects are in decline around the world. Can we make flowers better at being pollinated, to help solve this problem?

Research from the Glover Lab (https://twitter.com/Beverley_CUBG) in the Department of Plant Sciences (https://twitter.com/PlantSci)
Though a law requiring clinical trial results reporting has been on the books for decades, many researchers have been slow to comply. Now, 2 years after the law was sharpened with higher penalties for noncompliance, investigative correspondent Charles Piller took a look at the results. He talks with host Sarah Crespi about the investigation and a surprising lack of compliance and enforcement.
Also this week, Sarah talks with Brett Finlay, a microbiologist at the University Of British Columbia, Vancouver, about an Insight in this week’s issue that aims to connect the dots between noncommunicable diseases like heart disease, diabetes, and cancer and the microbes that live in our guts. Could these diseases actually spread through our microbiomes?
From a Genetic Engineering & Biotechnology News online article:
“We were able to show that if you can stop the plasmid from replicating, then most of the bacteria lose the plasmid as the bacteria grow and divide. This means that infections that might otherwise be hard to control, even with the most powerful antibiotics available, are more likely to be treatable with standard antibiotics.”

Researchers headed by a team at the University of Birmingham in the U.K. have developed a probiotic drink containing genetic elements that are designed to thwart antimicrobial resistance (AMR) in gut bacteria at the genetic level. The drink targets small DNA elements called plasmids that carry antibiotic resistance genes, and which are able to replicate independently and spread between bacteria. By preventing these plasmids from replicating, the antibiotic resistance genes are displaced, effectively resensitizing the bacteria to antibiotics.