Category Archives: Science

Science Podcasts: Low-Cost Cryo-Electron Microscopes & Genetic Roots Of Schizophrenia

Science Magazine PodcastsStructural biologists rejoiced when cryo–electron microscopy, a technique to generate highly detailed models of biomolecules, emerged. But years after its release, researchers still face long queues to access these machines. Science’s European News Editor Eric Hand walks host Meagan Cantwell through the journey of a group of researchers to create a cheaper, more accessible alternative.

Cryo-Electron Microscopes

Also this week, host Joel Goldberg speaks with psychiatrist and researcher Goodman Sibeko, who worked with the Xhosa people of South Africa to help illuminate genetic details of schizophrenia. Though scientists have examined this subject among Western populations, much less is known about the underlying genetics of people native to Africa.

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Top New Science Podcasts: Australian Fires, Isaac Asimov’s Robots And The Coronavirus (Nature)

Nature PodcastsListen to the latest from the world of science, with Benjamin Thompson and Nick Howe. This week, establishing climate change’s role in Australian bushfires, and revisiting Isaac Asimov’s thoughts robots.

In this episode:

00:46 Behind the bushfires

Researchers are working to establish the role that climate change is playing in the bushfires that are raging across Australia. News Feature: The race to decipher how climate change influenced Australia’s record firesEditorial: Australia: show the world what climate action looks like

10:02 Research Highlights

The debate around how Vesuvius claimed its victims, and an ancient mummy speaks. Research Highlight: Vitrified brains and baked bones tell the story of Vesuvius deathsResearch Article: Howard et al.

12:21 Asimov’s legacy

This year marks the centenary of Isaac Asimov’s birth. We reflect on the impact of his writing on the field of robotics. Essay: Isaac Asimov: centenary of the great explainer

21:00 News Chat

The latest on a new virus from Wuhan in China, and social scientists’ battle with bots. News: Coronavirus: latest news on spreading infection; News: Social scientists battle bots to glean insights from online chatter

Science And Technology: “3D Printing With Living Organisms” (MIT Video)

A method for printing 3D objects that can control living organisms in predicable ways has been developed by an interdisciplinary team of researchers at MIT and elsewhere. This technique may lead to 3D printing of biomedical tools that can be customized to fit the physical body and biomarkers of its users.

3D printing with living organisms MIT Video January 23 2020

 

(Learn more: http://news.mit.edu/2020/3-d-bioprint…)

Listen to an explainer on 3D bioprinting and biohybrid materials: https://soundcloud.com/mitnewsoffice/…

Science Podcasts: Stress Turns Hair Grey, Giant Sloths, Fake Whiskeys And Climate Change (Nature)

Nature PodcastsHear the latest science news, brought to you by Nick Howe and Benjamin Thompson.  This week, why stress makes mice turn grey, and how to think about climate change.

In this episode:

00:45 Going grey

Anecdotal evidence has long suggested stress as a cause of grey hair. Now, a team of researchers have showed experimental evidence to suggest this is the case. Research Article: Zhang et al.News & Views: How the stress of fight or flight turns hair white

08:39 Research Highlights

Ancient bones suggest that giant ground sloths moved in herds, plus an atomic way to check for whiskey fakes. Research Highlight: A bone bed reveals mass death of herd of giant ground slothsResearch Highlight: Nuclear-bomb carbon unmasks fraudulent luxury whisky

10:40 Climate optimism

To tackle climate change, the former UN secretary for climate change argues that the biggest change needs to be mindset. Comment: Paris taught me how to do what is necessary to combat climate change

18:09 News Chat

The latest on a new virus from Wuhan in China, and insights from ancient African genomes. News: China virus latest: first US case confirmedResearch Article: Lipson et al.

Research: Scientists Find Protein To Regulate Immune Attacks, Reduce Rheumatoid Arthritis

From a New Atlas online article:

1200px-Karolinska_Institutet_seal.svgScientists have just discovered a new mechanism that can be key in regulating these immune attacks, raising new hopes of drugs that can protect against joint inflammation and the ailments it can bring.

Through the use of the CRISPR gene-editing tool, the Karolinska Institutet scientists have now shed further light on the role they play in inflammation. The technology enabled the team to make adjustments to a set of hand-picked immune cell genes as a way of learning how those tweaks can impact the behavior of the cells.

“The results we obtained using CRISPR were key to quickly understanding how the system under study is regulated,” says Dr Wermeling. “I have high hopes that the experimental use of CRISPR will be hugely important to our understanding of how immune-cell behavior is regulated, and that this can guide us in the development of new efficacious drugs.”

https://newatlas.com/medical/newly-understood-protein-raises-hopes-of-advanced-arthritis-treatments/?utm_source=New+Atlas+Subscribers&utm_campaign=68b0bd3225-EMAIL_CAMPAIGN_2020_01_21_02_40&utm_medium=email&utm_term=0_65b67362bd-68b0bd3225-93002753

Nature & Science: Making Flowers Of Food Plants More Attractive To Insect Pollinators (Cambridge)

A rising world population means we’ll need more food in the coming years. But much of our food relies on insect pollination, and insects are in decline around the world. Can we make flowers better at being pollinated, to help solve this problem?

Improving flowers to help feed the world Cambridge University Video January 21 2020

Research from the Glover Lab (https://twitter.com/Beverley_CUBG) in the Department of Plant Sciences (https://twitter.com/PlantSci)

Top New Science Podcasts: Lack Of Clinical Trial Reporting, Gut Microbe Links To Chronic Disease

Science Magazine PodcastsThough a law requiring clinical trial results reporting has been on the books for decades, many researchers have been slow to comply. Now, 2 years after the law was sharpened with higher penalties for noncompliance, investigative correspondent Charles Piller took a look at the results. He talks with host Sarah Crespi about the investigation and a surprising lack of compliance and enforcement.

Also this week, Sarah talks with Brett Finlay, a microbiologist at the University Of British Columbia, Vancouver, about an Insight in this week’s issue that aims to connect the dots between noncommunicable diseases like heart disease, diabetes, and cancer and the microbes that live in our guts. Could these diseases actually spread through our microbiomes?

Study: “Probiotic Drink” Developed That Thwarts Antibiotic Resistance

From a Genetic Engineering & Biotechnology News online article:

Genetic Engineering & Biotechnology News logo“We were able to show that if you can stop the plasmid from replicating, then most of the bacteria lose the plasmid as the bacteria grow and divide. This means that infections that might otherwise be hard to control, even with the most powerful antibiotics available, are more likely to be treatable with standard antibiotics.”

journal.pone.0225202.g001
Fig 1. Anticipated exploitation of pCURE as a probiotic treatment for at-risk individuals. Before treatment, plasmids carrying antibiotic resistance genes are shown as purple circles. After treatment, target plasmids are replaced by pCURE (green circle) which could be engineered to later “self-destruct”. Note that not all gut bacteria carry resistance plasmids but pCURE can enter all Enterobacteriaceae as well as other bacteria. Reduced resistance levels in the gut decrease the chance of treatment failure when infections elsewhere in the body (eg lungs or urinary tract) arise from gut bacteria.

 

Researchers headed by a team at the University of Birmingham in the U.K. have developed a probiotic drink containing genetic elements that are designed to thwart antimicrobial resistance (AMR) in gut bacteria at the genetic level. The drink targets small DNA elements called plasmids that carry antibiotic resistance genes, and which are able to replicate independently and spread between bacteria. By preventing these plasmids from replicating, the antibiotic resistance genes are displaced, effectively resensitizing the bacteria to antibiotics.

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