

On this week’s show, Contributing Correspondent Kai Kupferschmidt talks with host Sarah Crespi about modeling coronavirus spread and the role of forecasts in national lockdowns and other pandemic policies. They also talk about the launch of a global trial of promising treatments.
Also this week, Nadine Gogolla, research group leader at the Max Planck Institute of Neurobiology, talks with Sarah about linking the facial expressions of mice to their emotional states using machine learning.
Scientists around the world are racing to develop a vaccine for COVID-19. But experts have said it could take a year to 18 months for one to hit the market. The process for testing and approving a vaccine is long and complicated.
That can be frustrating when the coronavirus is taking more and more lives every day. But cutting corners to push a vaccine through faster can lead to devastating consequences. We know that, because it’s happened before.
This week, reassessing the age of the ‘Broken Hill skull’, and unearthing evidence of an ancient forest near the South Pole.In this episode:
01:25 A skull’s place in history
After nearly a century scientists believe they’ve finally pinned down an age for the ‘Broken Hill skull’ hominid specimen. Research Article: Grun et al.
07:44 Research Highlights
A simple way to detect early signs of cancer, and 3D printed soft brain implants. Research Highlight: A blood test finds deadly cancers before symptoms start; Research Article: Yuk et al.
09:51 Ancient Antarctic rain forest
Digging deep below the sea-floor, researchers have uncovered evidence of a verdant forest that existed on Antarctica around 90 million years ago. Research Article: Klages et al.
15:47 Research Highlights
Walking more, regardless of the intensity, may improve health. Research Highlight: More steps a day might keep the doctor away
Alexander von Humboldt might not be a name you know, but you can bet you know his ideas. Back when the United States were a wee collection of colonies huddled on the eastern seaboard, colonists found the wilderness surrounding them scary. It took a zealous Prussian explorer with a thing for barometers to show the colonists what they couldn’t see: a global ecosystem, and their own place in nature. In this
episode, we learn how Humboldt—through science and art—inspired a key part of America’s national identity.
More fascinating Humboldt facts:
If you’re interested in learning more about the life and times of Alexander von Humboldt, I’d recommend reading Andrea Wulf’s book The Invention of Nature: Alexander von Humboldt’s New World.
Scientists and doctors have observed for thousands of years that some diseases, like polio and influenza, rise and fall with the seasons. But why? Ongoing research in animals and humans suggests a variety of causes, including changes in the environment (like pH, temperature, and humidity) and even seasonal and daily changes to our own immune systems. Figuring out those answers could one day make all the difference in minimizing the impact of infectious disease outbreaks—such as COVID-19.
Researchers have developed an ultra-fast electrical switch that they hope can be used in communication and imaging applications. In this episode:
01:57 Speedy switches
Researchers have developed an ultra-fast electrical switch that they hope can be used in communication and imaging applications. Research Article: Nikoo et al.
08:14 Research Highlights
Using sound to estimate glacial retreat, and building a dodgier drone. Research Highlight: Underwater microphones listen as as glacier retreats; Research article: Falanga et al.
10:32 Algorithmic heart diagnosis
Scientists have developed a new algorithm which calculates the amount of blood pumped by the heart beat by beat. Research Article: Ouyang et al.; News and Views: AI tracks a beating heart’s function over time
Sleep medicine, art and literature – ars longa, vita brevis. Organised by the Sleep Medicine Section 4 February 2020.
Professor Meir Kryger, Author and Professor, Yale School of Medicine – Sleep Disorders & Effective Treatments.
Lecture: Sleep in art: A 7000 year odyssey
The race is on to find a vaccine against the new COVID-19 coronavirus. Professor Jonathan Heeney explains why a cautious approach is needed and how his team is using new technology developed for influenza and Ebola viruses to target the new infection.
It is hard now to conceive that two months ago, few people had heard of the new coronavirus. Now, the virus, which causes the disease COVID-19, has spread to every corner of the globe. The World Health Organization has officially declared the outbreak a pandemic.
With the threat of hundreds of thousands – possibly millions – of people being infected and healthcare systems becoming overwhelmed, the race is on to develop a vaccine that will protect individuals and slow the spread of the disease. But Professor Jonathan Heeney, Head of the Laboratory of Viral Zoonotics at the University of Cambridge, and one of the people working on a vaccine, says that coronaviruses present a particular challenge to vaccine developers.
Coronaviruses are named after their appearance: they are spherical objects, on the surface of which sit ‘spike’ proteins. The virus uses these spikes to attach to and invade cells in our body. Once inside, the virus uses the cell’s own machinery to help itself replicate and spread throughout the body, causing disease and allowing it to transmit onwards.
Traditionally, scientists would develop vaccines that programme the body to produce antibodies that recognise and block these spikes. But this strategy can misfire with coronaviruses due to a phenomenon known as ‘antibody-induced enhancement’ or ‘vaccine-induced enhancement’, says Heeney.
“If you make antibodies against the spike, they can end up binding to it and helping the virus invade important immune cells known as monocyte-macrophages. Rather than destroying the virus, these cells can then end up being reprogrammed by the viruses, exacerbating the immune response and making the disease much, much worse than it would otherwise be.”