From a Diabetologia online study release (April 15, 2020):
“Having normal body weight is crucial in the prevention of type 2 diabetes, regardless of genetic predisposition.”
“The results suggest that type 2 diabetes prevention by weight management and healthy lifestyle is critical across all genetic risk groups.”
“Overall, the results indicate that a favorable lifestyle should be universally recommended in the prevention of type 2 diabetes, regardless of genetic predisposition, thus supporting current public health guidelines,”
We examined the joint association of genetic predisposition, obesity and unfavourable lifestyle with incident type 2 diabetes using a case-cohort study nested within the Diet, Cancer and Health cohort in Denmark. The study sample included 4729 individuals who developed type 2 diabetes during a median 14.7 years of follow-up, and a randomly selected cohort sample of 5402 individuals.
Obesity (BMI ≥ 30 kg/m2) and unfavourable lifestyle were associated with higher risk for incident type 2 diabetes regardless of genetic predisposition (p > 0.05 for GRS–obesity and GRS–lifestyle interaction). The effect of obesity on type 2 diabetes risk (HR 5.81 [95% CI 5.16, 6.55]) was high, whereas the effects of high genetic risk (HR 2.00 [95% CI 1.76, 2.27]) and unfavourable lifestyle (HR 1.18 [95% CI 1.06, 1.30]) were relatively modest.
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From a MD Magazine online release:
The investigators discovered that patients with a higher genetic risk for depression were more likely to be diagnosed with depression over the next 2 years. However, more physically active patients at baseline were less likely to depression, even after they accounted for genetic risks.
Increasing physical activity could pay dividends for people with a high risk of developing depression.
A team from Massachusetts General Hospital (MGH) recently discovered that several hours of weekly exercise result in a decreased chance to be diagnosed with a new episode of depression, even in patients with a higher genetic risk of developing Major Depressive Disorder (MDD).
The team examined the genomic and electronic health record (EHR) data of approximately 8000 patients in the Partners Healthcare Biobank, which represents the first study to show how physical activity influences depression despite genetic risk.
To read more: https://www.mdmag.com/medical-news/physical-activity-epressive-episode?eKey=bWljaGFlbDkyNjUxQHlhaG9vLmNvbQ==&utm_medium=email&utm_campaign=MDMagSS%20Daily%20Clinical%20eNews%20Sponsored%20Article%2011-5-19%20copy&utm_content=MDMagSS%20Daily%20Clinical%20eNews%20Sponsored%20Article%2011-5-19%20copy+CID_7326ad4f0f2426afa568130acb5dabae&utm_source=CM%20MDMag&utm_term=Physical%20Activity%20Reduces%20Odds%20of%20Depressive%20Episode
“Living a healthy lifestyle may help offset a person’s genetic risk of dementia, according to new research.
The study was led by the University of Exeter – simultaneously published today in JAMA and presented at the Alzheimer’s Association International Conference 2019 in Los Angeles. The research found that the risk of dementia was 32 per cent lower in people with a high genetic risk if they had followed a healthy lifestyle, compared to those who had an unhealthy lifestyle.
Participants with high genetic risk and an unfavourable lifestyle were almost three times more likely to develop dementia compared to those with a low genetic risk and favourable lifestyle.”
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