The New Yorker – December18, 2023 issue: The new issue‘s cover features Olimpia Zagnoli’s “Let There Be Lights” – The artist discusses strands of brilliance amid dark days.

All the Carcinogens We Cannot See

We routinely test for chemicals that cause mutations. What about the dark matter of carcinogens—substances that don’t create cancer cells but rouse them from their slumber?

By Siddhartha Mukherjee

In the nineteen-seventies, Bruce Ames, a biochemist at Berkeley, devised a way to test whether a chemical might cause cancer. Various tenets of cancer biology were already well established. Cancer resulted from genetic mutations—changes in a cell’s DNA sequence that typically cause the cell to divide uncontrollably. These mutations could be inherited, induced by viruses, or generated by random copying errors in dividing cells. They could also be produced by physical or chemical agents: radiation, ultraviolet light, benzene. One day, Ames had found himself reading the list of ingredients on a package of potato chips, and wondering how safe the chemicals used as preservatives really were.

The Troubled History of the Espionage Act

The law, passed in a frenzy after the First World War, is a disaster. Why is it still on the books?

By Amy Davidson Sorkin

In March, 1940, Edmund Carl Heine, a forty-nine-year-old American automobile executive, reached an understanding with a company then known as Volkswagenwerk GmbH. Heine, who immigrated to the United States from Germany as a young man, had spent years at Ford, first in Michigan and then in its international operations in South America and Europe, landing finally in Germany. In 1935, two years after the Nazi regime came to power, Ford fired him, for reasons that are unclear. Heine next signed on with Chrysler, in Spain, but the Spanish Civil War was tough on the car business. And so he was out of a job again.